For anyone interested in the MK-869 thread

[Guest guest]

I just came across an article saying Merck began phase III trials

for this in the third quarter of 2001, and expect to file for

regulatory approval in 2002, so maybe this will be another

possible option for treating cea by the end of this year,

especially for the people who have depression/anxiety that goes

along with it.

[Guest guest]

I think Adam is referring to oral Supstance P inhibitors actions on

severe vascular rosacea; the redness and flushing which is hard to

treat by conventional means... Nase makes references in his book to

some doctors who have had success with a similar drug (but with lots

more side effects) in his book, on just those symptoms.

Like NO and CGRP and a host of other neuro-peptides that cause

flushing and redness, Substance P is probably also intimately

involved in the flushing and redness.

.

> Adam, what's behind your saying that this is " another possible

option

> for treating rosacea? " Unless you're holding out on me, I've yet to

> understand how centrally-acting substance P inhibitors could be of

> help to the vast majority of rosaceans. Theoretically, those with

> disabling pain may respond to centrally acting substance p

> inhibitors, which I assume is what Dr. Nase originally was

referring

> to. But that's not maintstream rosacea -- my understanding is that

> the burning, stinging and itching of rosacea is usually secondary

to

> irritation and inflammation and resolves as those improve. Those

> rosaceans with disabling pain unresponsive to any rosacean

treatment

> are best referred to pain control specialists, who specialize in

> managing neurogenic pain.

>