For anyone interested in the MK-869 thread

[Guest guest]

I just came across an article saying Merck began phase III trials

for this in the third quarter of 2001, and expect to file for

regulatory approval in 2002, so maybe this will be another

possible option for treating cea by the end of this year,

especially for the people who have depression/anxiety that goes

along with it.

[Guest guest]

And I heard Merck's attention is now on another substance P

inhibitor, but it doesn't matter -- whichever drug they are working

on, it seemed it is being tested and promoted as an anti-depressant

that are as safe and effective as the SSRIs but without the sexual

side effects.

Adam, what's behind your saying that this is " another possible option

for treating rosacea? " Unless you're holding out on me, I've yet to

understand how centrally-acting substance P inhibitors could be of

help to the vast majority of rosaceans. Theoretically, those with

disabling pain may respond to centrally acting substance p

inhibitors, which I assume is what Dr. Nase originally was referring

to. But that's not maintstream rosacea -- my understanding is that

the burning, stinging and itching of rosacea is usually secondary to

irritation and inflammation and resolves as those improve. Those

rosaceans with disabling pain unresponsive to any rosacean treatment

are best referred to pain control specialists, who specialize in

managing neurogenic pain.

Marjorie

Marjorie Lazoff, MD

> I just came across an article saying Merck began phase III trials

> for this in the third quarter of 2001, and expect to file for

> regulatory approval in 2002, so maybe this will be another

> possible option for treating cea by the end of this year,

> especially for the people who have depression/anxiety that goes

> along with it.

>

>

>

>

[Guest guest]

And I heard Merck's attention is now on another substance P

inhibitor, but it doesn't matter -- whichever drug they are working

on, it seemed it is being tested and promoted as an anti-depressant

that are as safe and effective as the SSRIs but without the sexual

side effects.

Adam, what's behind your saying that this is " another possible option

for treating rosacea? " Unless you're holding out on me, I've yet to

understand how centrally-acting substance P inhibitors could be of

help to the vast majority of rosaceans. Theoretically, those with

disabling pain may respond to centrally acting substance p

inhibitors, which I assume is what Dr. Nase originally was referring

to. But that's not maintstream rosacea -- my understanding is that

the burning, stinging and itching of rosacea is usually secondary to

irritation and inflammation and resolves as those improve. Those

rosaceans with disabling pain unresponsive to any rosacean treatment

are best referred to pain control specialists, who specialize in

managing neurogenic pain.

Marjorie

Marjorie Lazoff, MD

> I just came across an article saying Merck began phase III trials

> for this in the third quarter of 2001, and expect to file for

> regulatory approval in 2002, so maybe this will be another

> possible option for treating cea by the end of this year,

> especially for the people who have depression/anxiety that goes

> along with it.

>

>

>

>