Re: Repost from Dr. Pilcher

[Guest guest]

Dr. Pilcher,

Please let us know when the product will be available and where we

can buy it.

Thanks,

Matija

> I would urge you to look at the degree of improvement between

control

> and treated groups rather than looking solely at numbers of those

> that improved. We fully agree that the control group did show

> improvement- in fact, it simply bolsters our confidence that we

have

> a highly moisturizing lotion that aids in the treatment of symptoms

> such as desquamation. We have seen this consistently in our eczema

> studies as well. Your point is well taken about dermal vs.

epidermal

> inflammation. We have found in our Franz cell analyses that we are

> able to obtain biologically active amounts of compound in the

dermis

> of human skin. So I personally believe that any effects in the

> epidermis will also be seen in the dermis as well.

>

> If there were no limitations on claims why would we claim to have a

> cure if it didn't cure rosacea? I hope that you see we are not

making

> those types of claims. In fact, all we have said since the firs

post

> is that it helps in improving symptoms. I don't want to sound

> defensive and am truly trying to keep an open mind. Please forgive

me

> if I feel just a little grilled over the coals J.

>

> The sunscreen effect you refer to is due to the molecular structure

> of Quadrinone. It was discovered in one of our initial UV studies

> that it had the ability to absorb UVR. In the very first clinical

> study performed by Cutanix patients were pre-dosed with the lotion

> prior to UV exposure. Naturally, the data came back incredibly

> positive and we were extremely pleased. Then we decided to test for

> UV absorbing capacity and indeed Quadrinone in a 5% lotion had an

spf

> of 8-9. We have since looked at 2% and 1% lotions and for those the

> spf is around 3-4 and 1-2, respectively. In all of our subsequent

> clinical studies we have post-dosed the subjects with control or

> active lotions after UV treatment to prevent skewing our data with

> the natural sunscreen characteristics of the molecule. In those

> studies Quadrinone effectively inhibit UV-induced erythema.

>

> It seems as though we are bound to disagree on much and I hope that

> none of our debate has been taken personally. Although, I have to

> admit that it has been hard for me at times. All that our company

> asks is that you give us a shot and see if the product works in

your

> case. Cheers to all in this group- you are why I do what I do.

>

> Pilcher