RE: Nicomide, B3, Niacinamide

[Guest guest]

Hi All -- Does the interaction of Nicomide Tablets and

tetraycyclines also apply to over the counter B3 -

Niacinimide and tetraycyclines? If so, what is the

interaction? After reading the warning below, I'm

wondering if I should discontinue Niacinimide while

taking doxycycline. Michele

--- jackogreen@...> wrote:

> Nicomide Tablets:

> Chemical Name: NICOTINAMIDE (NIK-oh-tin-a-mide),

> ZINC OXIDE (zink OX-ide),

> and FOLIC ACID (FOE-lik AS-id)

> Common uses

> This medicine is a vitamin and mineral combination

> used to certain types of

> acne (e.g., acne vulgaris or acne rosacea) or other

> irritated skin

> conditions. People who have low levels of

> nicotinamide, zinc, or folic acid

> may develop, or be at increased risk of developing

> these types of skin

> conditions.

>

> Before using:

> Some medicines or medical conditions may interact

> with this medicine. INFORM

> YOUR DOCTOR OR PHARMACIST of all prescription and

> over-the-counter medicine

> that you are taking. DO NOT TAKE THIS MEDICINE if

> you are also taking

> fluorouracil. ADDITIONAL MONITORING OF YOUR DOSE OR

> CONDITION may be needed

> if you are taking medicine for seizures,

> tetracyclines, or drug to lower

> cholesterol (statins). Inform your doctor of any

> other medical conditions,

> allergies, pregnancy, or breast-feeding.

__________________________________________________

[Guest guest]

This source at http://www.healthwell.com/healthnotes/Drug/Doxycycline.cfm

doesn't list any B3/doxycycline interaction issues:

Doxycycline

Also indexed as: Atridox®, Doryx®, Doxy®, Monodox®, Periostat®, Vibramycin®

Doxycycline is a tetracycline-like antibiotic. Doxycycline is used to treat

a wide variety of infections and to prevent traveler's diarrhea.

Interactions with Dietary Supplements ---

Minerals

Many minerals can decrease the absorption and reduce effectiveness of

doxycycline, including calcium, magnesium, iron, zinc, and others.1 To avoid

these interactions, doxycycline should be taken two hours before or two

hours after dairy products (high in calcium) and mineral-containing antacids

or supplements.

Vitamin K

As with many antibiotics, doxycycline can kill friendly bacteria in the

colon, potentially leading to reduced levels of vitamin K.2 Some doctors

believe that if doxycycline causes diarrhea for more than a few days, it

makes sense to supplement vitamin K (now found in some multivitamins).

Berberine-containing herbs

Berberine is a chemical extracted from goldenseal (Hydrastis canadensis),

barberry (Berberis vulgaris), and Oregon grape (Berberis aquifolium), which

has antibacterial activity. However, one double-blind study found that 100

mg berberine given with tetracycline (a drug closely related to doxycycline)

reduced the efficacy of tetracycline in people with cholera.3 In that trial,

berberine may have decreased tetracycline absorption. Another double-blind

trial found that berberine neither improved nor interfered with tetracycline

effectiveness in cholera patients.4 Therefore, it remains unclear whether a

significant interaction between berberine-containing herbs and doxycycline

and related drugs exists.

Interactions with Foods and Other Compounds ---

Food

Doxycycline may be taken with or without food and should be taken with a

full glass of water.5 However, doxycycline should not be taken with milk6 or

other dairy products.

Re: Nicomide, B3, Niacinamide

> Hi All -- Does the interaction of Nicomide Tablets and

> tetraycyclines also apply to over the counter B3 -

> Niacinimide and tetraycyclines? If so, what is the

> interaction? After reading the warning below, I'm

> wondering if I should discontinue Niacinimide while

> taking doxycycline. Michele

>

> --- jackogreen@...> wrote:

> > Nicomide Tablets:

> > Chemical Name: NICOTINAMIDE (NIK-oh-tin-a-mide),

> > ZINC OXIDE (zink OX-ide),

> > and FOLIC ACID (FOE-lik AS-id)

> > Common uses

> > This medicine is a vitamin and mineral combination

> > used to certain types of

> > acne (e.g., acne vulgaris or acne rosacea) or other

> > irritated skin

> > conditions. People who have low levels of

> > nicotinamide, zinc, or folic acid

> > may develop, or be at increased risk of developing

> > these types of skin

> > conditions.

> >

> > Before using:

> > Some medicines or medical conditions may interact

> > with this medicine. INFORM

> > YOUR DOCTOR OR PHARMACIST of all prescription and

> > over-the-counter medicine

> > that you are taking. DO NOT TAKE THIS MEDICINE if

> > you are also taking

> > fluorouracil. ADDITIONAL MONITORING OF YOUR DOSE OR

> > CONDITION may be needed

> > if you are taking medicine for seizures,

> > tetracyclines, or drug to lower

> > cholesterol (statins). Inform your doctor of any

> > other medical conditions,

> > allergies, pregnancy, or breast-feeding.

>

> __________________________________________________

>

[Guest guest]

Additional from HealthWell:

Drug Interactions Summary for Vitamin B3:

Here is a list of medications that may interact with vitamin B3. It is

recommended you discuss the use of vitamin B3 and your current medication(s)

with your doctor or pharmacist.

http://www.healthwell.com/healthnotes/Supp/Drugix/Vitamin_B3.cfm

Also:

Are there any side effects or interactions?

Niacinamide is almost always safe to take, though rare liver problems have

occurred at amounts in excess of 1,000 mg per day. Niacin, in amounts as low

as 50-100 mg, may cause flushing, headache, and stomachache in some people.

Doctors sometimes prescribe very high amounts of niacin (as much as 3,000 mg

per day or more) for certain health problems. These large amounts can cause

liver damage, diabetes, gastritis, damage to eyes, and elevated blood levels

of uric acid (which can cause gout), and should never be taken without

consulting a doctor.

Niacinamide taken in combination with the antibiotics tetracycline or

minocycline has produced beneficial effects in individuals with bullous

pemphigoid, a benign, autoimmune blistering condition of the skin.

The inositol hexaniacinate form of niacin has not been linked with the side

effects associated with niacin supplementation. In a group of people being

treated alternatively with niacin and inositol hexaniacinate for skin

problems, niacin supplementation (50-100 mg per day) was associated with

numerous side effects, including skin flushing, nausea, vomiting and

agitation.8 In contrast, people taking inositol hexaniacinate experienced no

complaints whatsoever, even at amounts two to five times higher than the

previously used amounts of niacin. However, the amount of research studying

the safety of inositol hexaniacinate remains quite limited. Therefore,

people taking this supplement in large amounts (2,000 mg per day or more)

should be under the care of a doctor.

Vitamin B3 works with vitamin B1 and vitamin B2 to release energy from

carbohydrates. Therefore, these vitamins are often taken together in a

B-complex or multivitamin supplement (although most B3 research uses niacin

or niacinamide by itself).