Guest guest Posted April 22, 2002 Report Share Posted April 22, 2002 > When Dr. Nase mentioned MK-869 in the book, he also mentioned that it was > going to be an oral drug. It would be nice if it turns out there are some > topical studies out there, but since Merck is testing it as a treatment for > depression, the odds probably are against this. I agree, Adam, it doesn't look like MK-869 -- or Zofran, which apparently also blocks Substance P centrally -- panned out as a oral pain medication, for rosacea or anyone else. It could turn out to have an off-label indication for pain syndromes, like Elavil when it first started out, but from what we're hearing it doesn't sound very hopeful. Still, Substance P antagonists, whether peripheral or centrally- acting, was never expected to treat or cure rosacea, or even impact on the majority of rosaceas. But neurogenic pain -- if that's the cause of the burning and stinging in rosaceans -- is an active area of research in pain control. Again, another example of research not involving rosacea will likely help that group of rosaceans. I'm learning a lot. It's nice to read others' contributations to these research threads. Thank you. As an aside: has anyone with burning/stinging symptoms tried cea Care's strontium lotion? I'm not recommending it, I'm just curious. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
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