Guest guest Posted September 15, 2006 Report Share Posted September 15, 2006 i will check into this because this does sound right --- i really doubt this- skip would spoken to the doctor-we don't fax back info -- so i will find out today cyndi [low dose naltrexone] LDN with betaseron? Is anyone taking LDN and betaseron concurrently? If so are you the touted benefits as well? I'm currently taking betaseron. I was looking at the Q's and A's at the Skip's Pharmacy LDN webpage (here's the link: http://skipspharmacy.com/ldn.php). It says " You can take LDN with Copaxone but not with Avonex or Beta Seron. " I've talked with my neuro about this, they ask for more info from Skip's and they faxed back that they have no information to substantiate their statement. It's sure nice to know I have a therapy to back me up just in case LDN doesn't work out for me. Take Care and GOD Bless! Rob Orris((>:}} Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 15, 2006 Report Share Posted September 15, 2006 Interferon beta inhibits the expression of pro-inflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor- alpha and beta, interferon gamma (INF-G) and IL-6. Interferon gamma is believed to be a major factor responsible for triggering the autoimmune reaction leading to multiple sclerosis. It is thought that INF-G stimulates cytotoxic T-cells and induces macrophages to produce proteinases that degrade the myelin sheath around the spinal cord. INF-G causes upregulation of class II MHC antigens on nervous system tissue; cytotoxic T-cells recognize these antigens as receptor sites and attack the tissue. The result is a progressive neurologic dysfunction. Interferon beta downregulates INF-G production and INF-G-stimulated class II MHC expression. Interferon beta reduces T-cell migration across the blood-brain barrier. Interferon beta has also been found to increase production of nerve growth factor (NGF), which promotes oligodendrocyte survival and differentiation and axonal recovery. This may have a favorable effect on remyelination. It is thought that LDN up -regulates depressed pro-inflammatory cytokines and down-regulates cytotox t-cells. Remember this is only a theory and there is great debate amongst LDN professionals regarding the actual mechanism of action. There has been no complete clinical studies validating this theory. If requested I would have told a neuro that this is only theory and there is no clinical or base studies to validate this theory. Dr.Skip Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 15, 2006 Report Share Posted September 15, 2006 , From what I've heard and read Copaxone is the only traditional therapy recommended with LDN since it is not an immunosuppressant. The others are, so they kind of cancel each other out. Go to www.low dose naltrexone.org. Marcie "Robt. Orris" <orrisx4@...> wrote: Is anyone taking LDN and betaseron concurrently? If so are you the touted benefits as well? I'm currently taking betaseron. I was looking at the Q's and A's at the Skip's Pharmacy LDN webpage (here's the link: http://skipspharmacy.com/ldn.php). It says " You can take LDN with Copaxone but not with Avonex or Beta Seron. " I've talked with my neuro about this, they ask for more info from Skip's and they faxed back that they have no information to substantiate their statement. It's sure nice to know I have a therapy to back me up just in case LDN doesn't work out for me. Take Care and GOD Bless! Rob Orris((>:}} Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 15, 2006 Report Share Posted September 15, 2006 i wasn't there so i can't be sure what was said but I can pretty guarantee skip told them what was recommended and sent them to the ldn.org page. but i think answering the question is there information like a double blind study to substantiate this is correct-there is only two things antidotal evidence and an understanding of how ldn works. somewhere here is that informationhttp://www.low dose naltrexone.org/cyndiOn Sep 15, 2006, at 9:52 AM, Marcie wrote: , From what I've heard and read Copaxone is the only traditional therapy recommended with LDN since it is not an immunosuppressant. The others are, so they kind of cancel each other out. Go to www.low dose naltrexone.org. Marcie "Robt. Orris" <orrisx4@...> wrote: Is anyone taking LDN and betaseron concurrently? If so are you the touted benefits as well? I'm currently taking betaseron. I was looking at the Q's and A's at the Skip's Pharmacy LDN webpage (here's the link: http://skipspharmacy.com/ldn.php). It says " You can take LDN with Copaxone but not with Avonex or Beta Seron. " I've talked with my neuro about this, they ask for more info from Skip's and they faxed back that they have no information to substantiate their statement. It's sure nice to know I have a therapy to back me up just in case LDN doesn't work out for me. Take Care and GOD Bless! Rob Orris((>:}} Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 17, 2006 Report Share Posted September 17, 2006 Thanks Dr. Skip. I appreciate this additional info.! Rob Orris >From: slenzrph@... >Reply-low dose naltrexone >low dose naltrexone >Subject: Re: [low dose naltrexone] LDN with betaseron? >Date: Fri, 1.5 Sep 2006 12:42:45 EDT >I >Interferon beta inhibits the expression of pro-inflammatory cytokines >including interleukin (IL)-1beta, tumor necrosis factor- alpha and beta, >interferon >gamma (INF-G) and IL-6. Interferon gamma is believed to be a major factor >responsible for triggering the autoimmune reaction leading to multiple >sclerosis. >It is thought that INF-G stimulates cytotoxic T-cells and induces >macrophages >to produce proteinases that degrade the myelin sheath around the spinal >cord. >INF-G causes upregulation of class II MHC antigens on nervous system >tissue; >cytotoxic T-cells recognize these antigens as receptor sites and attack the >tissue. The result is a progressive neurologic dysfunction. Interferon beta >downregulates INF-G production and INF-G-stimulated class II MHC >expression. >Interferon beta reduces T-cell migration across the blood-brain barrier. >Interferon >beta has also been found to increase production of nerve growth factor >(NGF), >which promotes oligodendrocyte survival and differentiation and axonal >recovery. This may have a favorable effect on remyelination. > >It is thought that LDN up -regulates depressed pro-inflammatory cytokines >and >down-regulates cytotox t-cells. Remember this is only a theory and there >is >great debate amongst LDN professionals regarding the actual mechanism of >action. There has been no complete clinical studies validating this >theory. If >requested I would have told a neuro that this is only theory and there is >no >clinical or base studies to validate this theory. >Dr.Skip Quote Link to comment Share on other sites More sharing options...
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