Reactions to ingredients (Was Re: Giving Gold Bond a try..)

[Guest guest]

I'm glad you brought this up because I've been thinking about this

for a while. cea induces cytokine production, anything which

causes a flare does, in fact, and cytokines significantly influence

comedone formation. Cunliff goes over cytokine induced comedones in

his book. This has been deomonstrated via cultured ducts in vitro

experimentally. It appears that rosacea and acne are more closely

linked that realized.

Which brings us to another question, when using too high dose of a

accutane on a rosacean, perhaps many of the intial flare pustules are

not there pre treatment as microcomedones but are manufactured due to

the rosacea/flush induced by the high dose accutane, before they are

expelled. This is one more argument to carefully monitor and

agressively reduce accutane dose for rosaceans when necessary.

Ideally, one should not need to worsen if it is done right.

It may be better to start at 10 mg M W F instead of 10 mg/d...

Antibiotics Big, Accutane Low --- sounds like a good bumper sticker.

>

> > by the way, dr nase, in his book, clearly explains to avoid

> > menthol, camphor, eucalyptus oil, and peppermint oil.

>

> The ingredients you listed are among those likely to cause

irritation

> to sensitive skin; it's not a complete list of the usual suspects,

> and it will not cause irritation to all sensitive skins. All skins

> react differently to different ingredients, and the sensitivities

> change as the skin becomes more or less healthy.

>

> So I'd disagree with Dr. Nase if he's truly advising all rosaceans

to

> avoid those ingredients, or any ingredient out of hand, as you

worded

> it above. I believe it's more realistic and helpful to view these

> ingredients -- and others -- with higher suspicion if they appear

as

> an ingredients that has already proven to cause a reaction.

>

> Note that irritation from ingredients as described above is

different

> than the breakouts from comedogenic ingredients, which you've

> thoughtfully warned the group about. Comedogenicity has to do with

> the size of pores and other skin characteristics rather than the

> health of skin. Those who react do, those who don't won't, and it

has

> nothing to do with rosacea per se (except that many rosaceans have

> larger pores that are easier to clog).

>

> The point is, comedogenic ingredients may cause breakouts in some

> rosaceans that make skin look worse, but that's not the rosacea

> worsening, as may well be the case with irritation from ingredient

> sensitivities.

>

> It's a subtly, but important in understanding the different

reactions

> possible from skin products. For example, if one takes antibotics

> while using a comedogenic skin product that causes acneform (acne-

> like) reaction, it may seem as if the antibiotics aren't working

or

> causing one type of pustule is being replaced by another, when

that's

> not what's happening at all.

In the case of one type of pustule, a rosacea mediated pustule caused

by immune system reaction, and an acne related pustule (like a

rosacea mediated pustule with the addition of p. acne involvement),

it would make sense to use either full dose zithromax or minocyline

because they work for either type of pustular etiology. Whereas,

tetracyline, doxycycline, clindamycin, and erythromycin, generally

are ineffective for acne pustules due to high p. acne resistance.

Additionally, isn't it ironic that retin a cream vehicle is

comedogenic?

>

> Marjorie

>

> Marjorie Lazoff, MD