Very interesting

[Guest guest]

Press Release

Source: Xanthus Pharmaceuticals, Inc.

Xanthus' Symadex Can Reverse Disease in Preclinical Multiple Sclerosis Animal ModelThursday September 28, 9:30 am ET

- Results Presented at the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis -

CAMBRIDGE, Mass., Sept. 28 /PRNewswire/ -- Xanthus Pharmaceuticals, Inc., a privately-held drug development company, today presented data that Symadex reverses the clinical and pathological signs of chronic disease in an animal model for multiple sclerosis (MS). The presentation was made by J. Karlik, PhD, Professor of Diagnostic Radiology at the University of Western Ontario, London, Ontario, together with researchers from Xanthus in a poster session at the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting in Madrid, Spain.

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Dr. Karlik used a model of experimental allergic encephalomyelitis (EAE) for the study. This same model was used by Dr. Karlik and his colleagues for published studies with natalizumab and related molecules. The study demonstrated that Symadex can reverse the clinical and pathological signs of chronic disease and that it can permit nerve remyelination. In addition, longer dosing resulted in continued benefit and the pathological changes including inflammation and vascular abnormalities were reversed. Importantly, Symadex did not affect circulating immune cell numbers, suggesting that it is not a general immunosuppressive agent. "We believe that Symadex has a distinct activity profile in the field of MS therapies. Interestingly, we found that Symadex has no effect on the acute, T-cell mediated portion of the disease process which is the target of most proposed new therapies for MS," stated Alfred Ajami, PhD, Chief Scientific Officer at Xanthus. About Symadex Symadex (formerly C-1311) is the lead compound in clinical development from a new series of agents, the imidazoacridinones, which have shown in vitro to be potent and selective FLT3 receptor tyrosine kinase inhibitors. Symadex is currently in Phase 2 clinical trials in oncology indications. Xanthus is also exploring the use of Symadex for the treatment of a number of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where early preclinical data has shown encouraging signs of activity. About Xanthus Pharmaceuticals, Inc. Xanthus Pharmaceuticals, Inc. is developing a portfolio of novel, clinical-stage, small-molecule oncology candidates through a management team whose accomplished track record encompasses all aspects of drug development, from discovery through regulatory approval and commercialization. The Company is applying its expertise both to advance its current pipeline and expand it into indications of unmet medical need beyond oncology. Xanthus is headquartered in Cambridge, Massachusetts with an additional facility in Montreal, Quebec. More information is available at http://www.xanthus.com. This press release contains forward-looking statements concerning Xanthus that involve a number of risks and uncertainties. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. Without limiting the foregoing, the words, "believes," "anticipates," "plans," "expects," "estimates," "intends," "should," "could," "will," "may," and similar expressions are intended to identify forward-looking statements. There are a number of important factors that could cause Xanthus' actual results to differ materially from those indicated by such forward-looking statements, including risks as to whether results obtained in early clinical studies or in preclinical studies such as the studies referred to above will be indicative of results obtained in future clinical trials or warrant additional trials; whether products based on Xanthus' technology will advance through the clinical trial process and receive approval from the United States Food and Drug Administration or equivalent foreign regulatory agencies; whether the company will have the cash resources to develop and commercialize its products; and whether the patent and patent applications owned or licensed by Xanthus will protect the Company's technology and prevent others from infringing it. Xanthus disclaims any intention or obligation to update any forward-looking statements. Contacts: Kari , MacDougall Biomedical Communications, Inc. -- kwatson@... or (508) 647-0209 Terry, Xanthus Pharmaceuticals, Inc. -- lisa.terry@... or (617) 225-0522, x 105

[Guest guest]

and what about that other new one, Novartis

How will they all impact LDN? are these 2 other options? Or are they "just as good" as the CRABs?

The thing is, if they are new options, anyone on LDN will definitely be more criticized for not trying those 2 which are FDA approved and 'official'

[low dose naltrexone] Very interesting

Press Release

Source: Xanthus Pharmaceuticals, Inc.

Xanthus' Symadex Can Reverse Disease in Preclinical Multiple Sclerosis Animal ModelThursday September 28, 9:30 am ET

- Results Presented at the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis -

CAMBRIDGE, Mass., Sept. 28 /PRNewswire/ -- Xanthus Pharmaceuticals, Inc., a privately-held drug development company, today presented data that Symadex reverses the clinical and pathological signs of chronic disease in an animal model for multiple sclerosis (MS). The presentation was made by J. Karlik, PhD, Professor of Diagnostic Radiology at the University of Western Ontario, London, Ontario, together with researchers from Xanthus in a poster session at the 22nd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting in Madrid, Spain.

[Guest guest]

In a message dated 8/9/2009 6:16:05 PM Eastern Daylight Time,

mwaspe@... writes:

Its really interesting to see how we are all so different.

so like the others have said we shouldn't compare ourselves, it should

just be a guide line.

A general question for our resident PTs....which might also help some feel

better about how thigns are going: i'd assume that rehab isn't

necessarily a straight line event anyway? (Uh oh, it JUST occurred to me I was

supposed to see a PT umm..a couple months ago for back rehab, oops)...anyway,

I'd think some peopel might well start of " fast " but then hit a platuea,

while others might get off to a slower start, but then catch up with some " fast

starters " and maybe even pass a few, but..at the end of some period of

time, almost everyone is at the same level...but that time might be what, a

year?

Just an assumption on my part, but if it's correct, it might help some

feel less discouraged about their rate of progress.

judith

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[Guest guest]

, I also think it's very interesting how our surgeons have such different

policies. I went home on day 3 & nobody knew or cared whether or not I could

bend my knee at all. Susie

> Its really interesting to see how we are all so different. so like the

others have said we shouldn't compare ourselves, it should just be a guide line.

> The surgeon I see for my knee, doesn't let his patients go home until they

get a bend to 90 degrees, and they usually do that in 5 days.

>

>

>