Guest guest Posted October 30, 2002 Report Share Posted October 30, 2002 Airways in cystic fibrosis are acidified: detection by exhaled breath condensate -- Thorax http://www.pulmonologylinx.com/thearts.cfm?artid=441747&specid=14 Conclusions: These findings support the hypothesis that airway acidification occurs in CF. This acidity is in part a function of inflammation as the pH of the EBC of patients increased significantly with treatment of an exacerbation, although not to control levels. Acidic pH of the ELF may play a role in the pathophysiology of CF lung disease and requires further investigation... ______________________________________________ Inflammatory Response in Airway Epithelial Cells Isolated from Patients with Cystic Fibrosis -- American Journal of Respiratory and Critical Care Medicine http://www.pulmonologylinx.com/thearts.cfm?artid=441697&specid=14 Conclusion: The results indicate that there is considerable variability in airway epithelial cell responses to inflammatory stimuli among different individuals and cell models systems. Although increased ICAM-1 and IL-8 expression are observed in some CF airway epithelial cell models, many CF cells do not exhibit significant dysregulation of these important inflammatory genes... Becki YOUR FAVORITE LilGooberGirl YOUNGLUNG EMAIL SUPPORT LIST www.topica.com/lists/younglung Pediatric Interstitial Lung Disease Society http://groups.yahoo.com/group/InterstitialLung_Kids/ Quote Link to comment Share on other sites More sharing options...
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