Re: Re: Klaron vs Noritate

[Guest guest]

I was on minocycline but when it seemed to lose its effectiveness, I switched to

doxcycline. You mention zithromax which I am not familiar with. Is this a new

drug for rosacea or one which has been around for awhile but is less known than

the tetracyclines? Do you take it every day and does it make you

photosensitive?

Also, where do you find brevoxyl 4%?

Thanks for the information,

a

Re: Klaron vs Noritate

>Well, another thing about noritate (metonidazole) in regards to

>acne. In addition to being an anti-inflammatory, it is an anaerobic

>antibiotic and should have some effect on the anaerobic p. acnes.

>

>

>Many times there is no rational theory behind combining two anti-

>inflammatory antibiotics, and certainly generally not from an id

>standpoint to reduce resistance because if you really wanted to

>reduce resistance you'd use oral minocyline (which p. acnes are

>resistant only to the tune of < 2%) or zithromax (unknown resistance

>but certainly much less than erthro, doxy, tetra, bactrim, etc.)

>

>I think it is kind of like throwing everything in and hoping

>something will work.

>

>I have a rational combination theory as follows. This is generally

>for the inflammatory acne component of rosacea and rosaceans with

>more inflammatory acne than erythema.

>

>Use brevoxyl 4% gel hs or bid. This is an aqueous based gel which is

>generally non irritating. Keep away from nose and nasolabial folds.

>Using bp for a week or two reduces p. acnes by a great amount,

>greater than oral antibiotics. Though you don't realize the anti

>inflammatory effect which oral antibiotics are famous for. Then use

>a q-tip and spot treat pustules with azeleic acid. Azelex picks up

>the slack on the anti-inflammatory front, and adds an appreciable

>comedolytic action to the inflammatory lesion. Using a q tip limits

>the irritation to only the pustule.

>

>Best part about this therapy -- no resistant p. acnes are selected

>for.

>

>For best results, as always, combine with a good oral therapy.

>

>

>

>

>> I have used Klaron in the morning and Noritate at night for several

>> years, and VERY rarely do I ever get any papules or pustules- they

>> dont seem to have much effect on the redness however- N.

>

>

>

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>

>See http://www.drnase.com for info on his recently published book.

>

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>