Re: Repost:: Cosmetic/Skincare Breakouts

[Guest guest]

<

>

well ...

let me just say that:

i have been a sun avoider

my whole life

and now

i get rosacea outbreaks

in the winter

when the sun is

barely barely

(and

i have to admit

i'm such a wimp about the cold

i don't ski

or do any out door games

that expose my face

to

the pale lemon

winter sun ...)

so

as my skin gets worse and worse

gee

i wish i could blame it on the sun

but i can't.

stacey

[Guest guest]

<

>

well ...

let me just say that:

i have been a sun avoider

my whole life

and now

i get rosacea outbreaks

in the winter

when the sun is

barely barely

(and

i have to admit

i'm such a wimp about the cold

i don't ski

or do any out door games

that expose my face

to

the pale lemon

winter sun ...)

so

as my skin gets worse and worse

gee

i wish i could blame it on the sun

but i can't.

stacey

[Guest guest]

<

>

well ...

let me just say that:

i have been a sun avoider

my whole life

and now

i get rosacea outbreaks

in the winter

when the sun is

barely barely

(and

i have to admit

i'm such a wimp about the cold

i don't ski

or do any out door games

that expose my face

to

the pale lemon

winter sun ...)

so

as my skin gets worse and worse

gee

i wish i could blame it on the sun

but i can't.

stacey

[Guest guest]

Instead of figuring out the mechanism by which sun causes/stimulates

rosacea and figuring out how to block the mechanism, we already know

to avoid the sun. If people now would avoid the sun, then less

people would get rosacea. It is so simple, it doesn't require any

research or cliical studies either... Those who have rosacea, if

they avoid the sun, then their rosacea will progress less ferociously.

> I'll leave this anonymous, but the points raised are interesting:

>

> >> is there an anatomic or physiologic feature of phototype I skin

> >> (most common skin type in both skin sensitivity and rosacea,

both

> >> of which involve burning) that makes it especially suspectible to

> >> neurosensory symptoms?

>

> > The NRS is doing a fair amount of research that has lead them to

> > believe there may be an important connection between sunlight and

a

> > VEGF response in the development of cea. I guess those with

> > lighter skin color would be more sensitive to the sun which would

> > maybe cause whatever weird reaction happens with the VEGF to

happen

> > even more? I don't know if this is even remotely close to what

you

> > were looking for, but if it is you can read more about it at the

> > NRS's website.

>

> The results from the study out of Boston U should be available

soon.

> I wouldn't be surprised if they find a relationship between VEGF

> (vascular endothial growth factor) and sunburn, but I'm not certain

> how they will ultimately relate this all to rosacea.

>

> Here's what they said in their Spring 2002 newsletter: " Research

> funded by the National cea Society is currently exploring

whether

> exposure to ultraviolet light, found in sunlight, leads to skin

that

> has increased receptors for vascular endothelial growth factor

> (VEGF).

>

> VEGF has a potent effect on blood vessels and may be associated

with

> rosacea by abnormally increasing facial blood supply. A previous

> study funded by the Society found that in rosacea-prone

individuals,

> the effects of the sun on epidermal VEGF may lead to persistent

> redness and the development of telangiectasia, the visible dilated

> blood vessels that are a common sign of rosacea. "

>

> Here's information on their Boston U funded study, which may or may

> be the one referred to above (from their Fall 2001

newsletter): " Dr.

> Marita Kosmadaki, a research fellow in the Department of

Dermatology,

> Boston University, reported interim results of the study, " The role

> of vascular endothelial growth factor (VEGF) in rosacea

development, "

> now in its second year of funding by the Society. Based on study

> results the first year, Dr. Kosmadaki and colleagues concluded that

> the effects of the sun on VEGF, a natural substance in the body

that

> has a potent effect on blood vessels, may lead to persistent

redness

> and the development of telangiectasia (visible blood vessels).

>

> This year, the researchers noted that TNF alpha, a substance that

> makes the skin more receptive to VEGF, was stimulated by the sun,

and

> they are now studying whether blocking TNF alpha may inhibit

rosacea

> development. "

>

> [TNF alpha is an immune-mediated cytokine]

>

> >> -?increased incidence of other skin disorders, esp acne vulgaris,

> >> seborrheic dermatitis, eczema and irritant contact dermatitis ---

>

> > Also in one of their reviews they had conducted survey and a very

> > large percentage of people reported having at least one other

skin

> > disorder. I think it was much higher than normal.

>

> The NRS surveys are interesting but they are not scientific

surveys,

> in that the 1000+ respondants are not randomly selected from among

> the 14 million+ rosacea sufferers -- they are self-selected among

> those who read the paper or electronic version of their newsletter,

> and decided to fill out the form. We can no better generalize the

> results for the rosacean population than we can, say, the results

of

> an MSNBC Web site poll. A scientific survey, like the ones

conducted

> by Gallop, uses statistics to select a representative sample of a

> population, and contacts them for participation.

>

> So I think we should keep the question mark there, until we find a

> survey whose results are valid and reliable.

>

> Marjorie

>

> Marjorie Lazoff, MD

[Guest guest]

Yes, but unless one lives in a cave and never leave

it, completely avoiding the sun is nearly impossible.

--- doubleoh7_mi6 ciz@...> wrote:

> Instead of figuring out the mechanism by which sun

> causes/stimulates

> rosacea and figuring out how to block the mechanism,

> we already know

> to avoid the sun. If people now would avoid the

> sun, then less

> people would get rosacea. It is so simple, it

> doesn't require any

> research or cliical studies either... Those who

> have rosacea, if

> they avoid the sun, then their rosacea will progress

> less ferociously.

>

>

>

>

> > I'll leave this anonymous, but the points raised

> are interesting:

> >

> > >> is there an anatomic or physiologic feature of

> phototype I skin

> > >> (most common skin type in both skin sensitivity

> and rosacea,

> both

> > >> of which involve burning) that makes it

> especially suspectible to

> > >> neurosensory symptoms?

> >

> > > The NRS is doing a fair amount of research that

> has lead them to

> > > believe there may be an important connection

> between sunlight and

> a

> > > VEGF response in the development of cea. I

> guess those with

> > > lighter skin color would be more sensitive to

> the sun which would

> > > maybe cause whatever weird reaction happens with

> the VEGF to

> happen

> > > even more? I don't know if this is even

> remotely close to what

> you

> > > were looking for, but if it is you can read more

> about it at the

> > > NRS's website.

> >

> > The results from the study out of Boston U should

> be available

> soon.

> > I wouldn't be surprised if they find a

> relationship between VEGF

> > (vascular endothial growth factor) and sunburn,

> but I'm not certain

> > how they will ultimately relate this all to

> rosacea.

> >

> > Here's what they said in their Spring 2002

> newsletter: " Research

> > funded by the National cea Society is

> currently exploring

> whether

> > exposure to ultraviolet light, found in sunlight,

> leads to skin

> that

> > has increased receptors for vascular endothelial

> growth factor

> > (VEGF).

> >

> > VEGF has a potent effect on blood vessels and may

> be associated

> with

> > rosacea by abnormally increasing facial blood

> supply. A previous

> > study funded by the Society found that in

> rosacea-prone

> individuals,

> > the effects of the sun on epidermal VEGF may lead

> to persistent

> > redness and the development of telangiectasia, the

> visible dilated

> > blood vessels that are a common sign of rosacea. "

> >

> > Here's information on their Boston U funded study,

> which may or may

> > be the one referred to above (from their Fall 2001

>

> newsletter): " Dr.

> > Marita Kosmadaki, a research fellow in the

> Department of

> Dermatology,

> > Boston University, reported interim results of the

> study, " The role

> > of vascular endothelial growth factor (VEGF) in

> rosacea

> development, "

> > now in its second year of funding by the Society.

> Based on study

> > results the first year, Dr. Kosmadaki and

> colleagues concluded that

> > the effects of the sun on VEGF, a natural

> substance in the body

> that

> > has a potent effect on blood vessels, may lead to

> persistent

> redness

> > and the development of telangiectasia (visible

> blood vessels).

> >

> > This year, the researchers noted that TNF alpha, a

> substance that

> > makes the skin more receptive to VEGF, was

> stimulated by the sun,

> and

> > they are now studying whether blocking TNF alpha

> may inhibit

> rosacea

> > development. "

> >

> > [TNF alpha is an immune-mediated cytokine]

> >

> > >> -?increased incidence of other skin disorders,

> esp acne vulgaris,

> > >> seborrheic dermatitis, eczema and irritant

> contact dermatitis ---

> >

> > > Also in one of their reviews they had conducted

> survey and a very

> > > large percentage of people reported having at

> least one other

> skin

> > > disorder. I think it was much higher than

> normal.

> >

> > The NRS surveys are interesting but they are not

> scientific

> surveys,

> > in that the 1000+ respondants are not randomly

> selected from among

> > the 14 million+ rosacea sufferers -- they are

> self-selected among

> > those who read the paper or electronic version of

> their newsletter,

> > and decided to fill out the form. We can no better

> generalize the

> > results for the rosacean population than we can,

> say, the results

> of

> > an MSNBC Web site poll. A scientific survey, like

> the ones

> conducted

> > by Gallop, uses statistics to select a

> representative sample of a

> > population, and contacts them for participation.

> >

> > So I think we should keep the question mark there,

> until we find a

> > survey whose results are valid and reliable.

> >

> > Marjorie

> >

> > Marjorie Lazoff, MD

>

>

>

> --

> Please read the list highlights before posting to

> the whole group (http://rosacea.ii.net/toc.html).

> Your post will be delayed if you don't give a

> meaningful subject or trim your reply text. You must

> change the subject when replying to a digest !

>

> See http://www.drnase.com for info on his recently

> published book.

>

> To leave the list send an email to

> rosacea-support-unsubscribe

>

>

[Guest guest]

Yes, but unless one lives in a cave and never leave

it, completely avoiding the sun is nearly impossible.

--- doubleoh7_mi6 ciz@...> wrote:

> Instead of figuring out the mechanism by which sun

> causes/stimulates

> rosacea and figuring out how to block the mechanism,

> we already know

> to avoid the sun. If people now would avoid the

> sun, then less

> people would get rosacea. It is so simple, it

> doesn't require any

> research or cliical studies either... Those who

> have rosacea, if

> they avoid the sun, then their rosacea will progress

> less ferociously.

>

>

>

>

> > I'll leave this anonymous, but the points raised

> are interesting:

> >

> > >> is there an anatomic or physiologic feature of

> phototype I skin

> > >> (most common skin type in both skin sensitivity

> and rosacea,

> both

> > >> of which involve burning) that makes it

> especially suspectible to

> > >> neurosensory symptoms?

> >

> > > The NRS is doing a fair amount of research that

> has lead them to

> > > believe there may be an important connection

> between sunlight and

> a

> > > VEGF response in the development of cea. I

> guess those with

> > > lighter skin color would be more sensitive to

> the sun which would

> > > maybe cause whatever weird reaction happens with

> the VEGF to

> happen

> > > even more? I don't know if this is even

> remotely close to what

> you

> > > were looking for, but if it is you can read more

> about it at the

> > > NRS's website.

> >

> > The results from the study out of Boston U should

> be available

> soon.

> > I wouldn't be surprised if they find a

> relationship between VEGF

> > (vascular endothial growth factor) and sunburn,

> but I'm not certain

> > how they will ultimately relate this all to

> rosacea.

> >

> > Here's what they said in their Spring 2002

> newsletter: " Research

> > funded by the National cea Society is

> currently exploring

> whether

> > exposure to ultraviolet light, found in sunlight,

> leads to skin

> that

> > has increased receptors for vascular endothelial

> growth factor

> > (VEGF).

> >

> > VEGF has a potent effect on blood vessels and may

> be associated

> with

> > rosacea by abnormally increasing facial blood

> supply. A previous

> > study funded by the Society found that in

> rosacea-prone

> individuals,

> > the effects of the sun on epidermal VEGF may lead

> to persistent

> > redness and the development of telangiectasia, the

> visible dilated

> > blood vessels that are a common sign of rosacea. "

> >

> > Here's information on their Boston U funded study,

> which may or may

> > be the one referred to above (from their Fall 2001

>

> newsletter): " Dr.

> > Marita Kosmadaki, a research fellow in the

> Department of

> Dermatology,

> > Boston University, reported interim results of the

> study, " The role

> > of vascular endothelial growth factor (VEGF) in

> rosacea

> development, "

> > now in its second year of funding by the Society.

> Based on study

> > results the first year, Dr. Kosmadaki and

> colleagues concluded that

> > the effects of the sun on VEGF, a natural

> substance in the body

> that

> > has a potent effect on blood vessels, may lead to

> persistent

> redness

> > and the development of telangiectasia (visible

> blood vessels).

> >

> > This year, the researchers noted that TNF alpha, a

> substance that

> > makes the skin more receptive to VEGF, was

> stimulated by the sun,

> and

> > they are now studying whether blocking TNF alpha

> may inhibit

> rosacea

> > development. "

> >

> > [TNF alpha is an immune-mediated cytokine]

> >

> > >> -?increased incidence of other skin disorders,

> esp acne vulgaris,

> > >> seborrheic dermatitis, eczema and irritant

> contact dermatitis ---

> >

> > > Also in one of their reviews they had conducted

> survey and a very

> > > large percentage of people reported having at

> least one other

> skin

> > > disorder. I think it was much higher than

> normal.

> >

> > The NRS surveys are interesting but they are not

> scientific

> surveys,

> > in that the 1000+ respondants are not randomly

> selected from among

> > the 14 million+ rosacea sufferers -- they are

> self-selected among

> > those who read the paper or electronic version of

> their newsletter,

> > and decided to fill out the form. We can no better

> generalize the

> > results for the rosacean population than we can,

> say, the results

> of

> > an MSNBC Web site poll. A scientific survey, like

> the ones

> conducted

> > by Gallop, uses statistics to select a

> representative sample of a

> > population, and contacts them for participation.

> >

> > So I think we should keep the question mark there,

> until we find a

> > survey whose results are valid and reliable.

> >

> > Marjorie

> >

> > Marjorie Lazoff, MD

>

>

>

> --

> Please read the list highlights before posting to

> the whole group (http://rosacea.ii.net/toc.html).

> Your post will be delayed if you don't give a

> meaningful subject or trim your reply text. You must

> change the subject when replying to a digest !

>

> See http://www.drnase.com for info on his recently

> published book.

>

> To leave the list send an email to

> rosacea-support-unsubscribe

>

>

[Guest guest]

Yes, but unless one lives in a cave and never leave

it, completely avoiding the sun is nearly impossible.

--- doubleoh7_mi6 ciz@...> wrote:

> Instead of figuring out the mechanism by which sun

> causes/stimulates

> rosacea and figuring out how to block the mechanism,

> we already know

> to avoid the sun. If people now would avoid the

> sun, then less

> people would get rosacea. It is so simple, it

> doesn't require any

> research or cliical studies either... Those who

> have rosacea, if

> they avoid the sun, then their rosacea will progress

> less ferociously.

>

>

>

>

> > I'll leave this anonymous, but the points raised

> are interesting:

> >

> > >> is there an anatomic or physiologic feature of

> phototype I skin

> > >> (most common skin type in both skin sensitivity

> and rosacea,

> both

> > >> of which involve burning) that makes it

> especially suspectible to

> > >> neurosensory symptoms?

> >

> > > The NRS is doing a fair amount of research that

> has lead them to

> > > believe there may be an important connection

> between sunlight and

> a

> > > VEGF response in the development of cea. I

> guess those with

> > > lighter skin color would be more sensitive to

> the sun which would

> > > maybe cause whatever weird reaction happens with

> the VEGF to

> happen

> > > even more? I don't know if this is even

> remotely close to what

> you

> > > were looking for, but if it is you can read more

> about it at the

> > > NRS's website.

> >

> > The results from the study out of Boston U should

> be available

> soon.

> > I wouldn't be surprised if they find a

> relationship between VEGF

> > (vascular endothial growth factor) and sunburn,

> but I'm not certain

> > how they will ultimately relate this all to

> rosacea.

> >

> > Here's what they said in their Spring 2002

> newsletter: " Research

> > funded by the National cea Society is

> currently exploring

> whether

> > exposure to ultraviolet light, found in sunlight,

> leads to skin

> that

> > has increased receptors for vascular endothelial

> growth factor

> > (VEGF).

> >

> > VEGF has a potent effect on blood vessels and may

> be associated

> with

> > rosacea by abnormally increasing facial blood

> supply. A previous

> > study funded by the Society found that in

> rosacea-prone

> individuals,

> > the effects of the sun on epidermal VEGF may lead

> to persistent

> > redness and the development of telangiectasia, the

> visible dilated

> > blood vessels that are a common sign of rosacea. "

> >

> > Here's information on their Boston U funded study,

> which may or may

> > be the one referred to above (from their Fall 2001

>

> newsletter): " Dr.

> > Marita Kosmadaki, a research fellow in the

> Department of

> Dermatology,

> > Boston University, reported interim results of the

> study, " The role

> > of vascular endothelial growth factor (VEGF) in

> rosacea

> development, "

> > now in its second year of funding by the Society.

> Based on study

> > results the first year, Dr. Kosmadaki and

> colleagues concluded that

> > the effects of the sun on VEGF, a natural

> substance in the body

> that

> > has a potent effect on blood vessels, may lead to

> persistent

> redness

> > and the development of telangiectasia (visible

> blood vessels).

> >

> > This year, the researchers noted that TNF alpha, a

> substance that

> > makes the skin more receptive to VEGF, was

> stimulated by the sun,

> and

> > they are now studying whether blocking TNF alpha

> may inhibit

> rosacea

> > development. "

> >

> > [TNF alpha is an immune-mediated cytokine]

> >

> > >> -?increased incidence of other skin disorders,

> esp acne vulgaris,

> > >> seborrheic dermatitis, eczema and irritant

> contact dermatitis ---

> >

> > > Also in one of their reviews they had conducted

> survey and a very

> > > large percentage of people reported having at

> least one other

> skin

> > > disorder. I think it was much higher than

> normal.

> >

> > The NRS surveys are interesting but they are not

> scientific

> surveys,

> > in that the 1000+ respondants are not randomly

> selected from among

> > the 14 million+ rosacea sufferers -- they are

> self-selected among

> > those who read the paper or electronic version of

> their newsletter,

> > and decided to fill out the form. We can no better

> generalize the

> > results for the rosacean population than we can,

> say, the results

> of

> > an MSNBC Web site poll. A scientific survey, like

> the ones

> conducted

> > by Gallop, uses statistics to select a

> representative sample of a

> > population, and contacts them for participation.

> >

> > So I think we should keep the question mark there,

> until we find a

> > survey whose results are valid and reliable.

> >

> > Marjorie

> >

> > Marjorie Lazoff, MD

>

>

>

> --

> Please read the list highlights before posting to

> the whole group (http://rosacea.ii.net/toc.html).

> Your post will be delayed if you don't give a

> meaningful subject or trim your reply text. You must

> change the subject when replying to a digest !

>

> See http://www.drnase.com for info on his recently

> published book.

>

> To leave the list send an email to

> rosacea-support-unsubscribe

>

>