Reactions to ingredients (Was Re: Giving Gold Bond a try..)

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> Perhaps the most efficient thing would be to develop a profile of

> rosaceans who are acne prone, which would include things such as

> history of severe acne during puberty, history of breakouts in

> relation to applying topicals, high sebum production, younger in

> age, male rather than female, and apply this profile as a relative

> indication for choosing minocycline over doxycyline as a first line

> therapy.

You're assuming the reason people fail initial treatment is because

acne vulgaris is not being diagnosed and so remains untreated. To

prevent that (unproven) assertion, you advocate exposing everyone to

some statistical analysis. Doesn't make sense to me, because a

competent dermatologist will diagnoses the presence of only rosacea,

or both rosacea and acne vulgaris, by just looking at the patient's

face.

> True there are other causes of acne through other mechanisms

> besides purely cytokines. However, it is interesting to note that

> inflammation begets more inflammation and worsening of the

> condition.

True for all inflammatory conditions, in fact for all physical

impairments. An already sprained ankle is easier to resprain; a

person with angina will experience more chest pain with relatively

less coronary artery narrowing than a person without anginal

symptoms.

> A pure rosacean can likely be converted into a rosacean

> plus an acne sufferer...

007, there's no physiologic equivalent to your " converting " --

unhealthy skin from whatever cause (for example, from rosacea) may

encourage, among other things, abnormal keratinization which, in some

people, may predispose to pore clogging.

> All roads leads to low dose accutane in these two situations...

You mean all roads lead to increasing your stock investments.

> In order to convince you, try getting the vehicle w/o the retin a

> and apply it to your facial skin and see what happens.

007, that's called the control group!

Consider the uselessness in applying isotrentoin without the vehicle

ingredients to allow absorption into the skin. You're fantasizing the

perfect vehicle, whereas the drug companies balance the reality of

ingredient limitations and side effects with what the active drug

needs to be effective.

Marjorie

Marjorie Lazoff, MD