Guest guest Posted March 29, 2002 Report Share Posted March 29, 2002 I have used Klaron in the morning and Noritate at night for several years, and VERY rarely do I ever get any papules or pustules- they dont seem to have much effect on the redness however- N. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2002 Report Share Posted March 29, 2002 Well, another thing about noritate (metonidazole) in regards to acne. In addition to being an anti-inflammatory, it is an anaerobic antibiotic and should have some effect on the anaerobic p. acnes. Many times there is no rational theory behind combining two anti- inflammatory antibiotics, and certainly generally not from an id standpoint to reduce resistance because if you really wanted to reduce resistance you'd use oral minocyline (which p. acnes are resistant only to the tune of < 2%) or zithromax (unknown resistance but certainly much less than erthro, doxy, tetra, bactrim, etc.) I think it is kind of like throwing everything in and hoping something will work. I have a rational combination theory as follows. This is generally for the inflammatory acne component of rosacea and rosaceans with more inflammatory acne than erythema. Use brevoxyl 4% gel hs or bid. This is an aqueous based gel which is generally non irritating. Keep away from nose and nasolabial folds. Using bp for a week or two reduces p. acnes by a great amount, greater than oral antibiotics. Though you don't realize the anti inflammatory effect which oral antibiotics are famous for. Then use a q-tip and spot treat pustules with azeleic acid. Azelex picks up the slack on the anti-inflammatory front, and adds an appreciable comedolytic action to the inflammatory lesion. Using a q tip limits the irritation to only the pustule. Best part about this therapy -- no resistant p. acnes are selected for. For best results, as always, combine with a good oral therapy. > I have used Klaron in the morning and Noritate at night for several > years, and VERY rarely do I ever get any papules or pustules- they > dont seem to have much effect on the redness however- N. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2002 Report Share Posted March 29, 2002 Well, another thing about noritate (metonidazole) in regards to acne. In addition to being an anti-inflammatory, it is an anaerobic antibiotic and should have some effect on the anaerobic p. acnes. Many times there is no rational theory behind combining two anti- inflammatory antibiotics, and certainly generally not from an id standpoint to reduce resistance because if you really wanted to reduce resistance you'd use oral minocyline (which p. acnes are resistant only to the tune of < 2%) or zithromax (unknown resistance but certainly much less than erthro, doxy, tetra, bactrim, etc.) I think it is kind of like throwing everything in and hoping something will work. I have a rational combination theory as follows. This is generally for the inflammatory acne component of rosacea and rosaceans with more inflammatory acne than erythema. Use brevoxyl 4% gel hs or bid. This is an aqueous based gel which is generally non irritating. Keep away from nose and nasolabial folds. Using bp for a week or two reduces p. acnes by a great amount, greater than oral antibiotics. Though you don't realize the anti inflammatory effect which oral antibiotics are famous for. Then use a q-tip and spot treat pustules with azeleic acid. Azelex picks up the slack on the anti-inflammatory front, and adds an appreciable comedolytic action to the inflammatory lesion. Using a q tip limits the irritation to only the pustule. Best part about this therapy -- no resistant p. acnes are selected for. For best results, as always, combine with a good oral therapy. > I have used Klaron in the morning and Noritate at night for several > years, and VERY rarely do I ever get any papules or pustules- they > dont seem to have much effect on the redness however- N. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2002 Report Share Posted March 29, 2002 Well, another thing about noritate (metonidazole) in regards to acne. In addition to being an anti-inflammatory, it is an anaerobic antibiotic and should have some effect on the anaerobic p. acnes. Many times there is no rational theory behind combining two anti- inflammatory antibiotics, and certainly generally not from an id standpoint to reduce resistance because if you really wanted to reduce resistance you'd use oral minocyline (which p. acnes are resistant only to the tune of < 2%) or zithromax (unknown resistance but certainly much less than erthro, doxy, tetra, bactrim, etc.) I think it is kind of like throwing everything in and hoping something will work. I have a rational combination theory as follows. This is generally for the inflammatory acne component of rosacea and rosaceans with more inflammatory acne than erythema. Use brevoxyl 4% gel hs or bid. This is an aqueous based gel which is generally non irritating. Keep away from nose and nasolabial folds. Using bp for a week or two reduces p. acnes by a great amount, greater than oral antibiotics. Though you don't realize the anti inflammatory effect which oral antibiotics are famous for. Then use a q-tip and spot treat pustules with azeleic acid. Azelex picks up the slack on the anti-inflammatory front, and adds an appreciable comedolytic action to the inflammatory lesion. Using a q tip limits the irritation to only the pustule. Best part about this therapy -- no resistant p. acnes are selected for. For best results, as always, combine with a good oral therapy. > I have used Klaron in the morning and Noritate at night for several > years, and VERY rarely do I ever get any papules or pustules- they > dont seem to have much effect on the redness however- N. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 > I was on minocycline but when it seemed to lose its effectiveness, I switched to > doxcycline. You mention zithromax which I am not familiar with. Is this a new > drug for rosacea or one which has been around for awhile but is less known than > the tetracyclines? Do you take it every day and does it make you photosensitive? a, Zithromax (azithromycin) is another type of antibiotic, a variant of erythomycin. All antibiotics work by the same proposed anti-inflammatory mechanism. Its chief benefit is that it is easier to maintain a good blood level because it is taken only once a day and isn't inactivated by dairy products or antacids. It also does not cause photosensitivity, and can be taken on an empty stomach. The downside is that it is quite expensive, far more so than even doxycycline, and has more potential side effects than does the tetracyclines (although it is still a relatively safe drug). The erythromycins as a group are less effective in most rosaceans than are the tetracycles/doxycyclines, but if doxycycline doesn't work for you it is an option to discuss with your doctor, especially if it's inconvenient to take pills every 12 hours. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 For rosacea 500 mg zithro loading with 250mg qd thereafter is miles ahead of the others. But you should try minocyline first because that may work indefinately for you. At least try 100 mg Minocin or generic equivalent bid before graduating to Zithromax. Save Zithromax for when minocyline stops working or if you can't use Accutane. Int J Dermatol 2000 Jan;39(1):45-50 Related Articles, Books, LinkOut Azithromycin for the treatment of acne. Fernandez-Obregon AC. Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. BACKGROUND: Acne affects a large number of young adults, including women, who often present with facial as well as truncal involvement. Systemic antimicrobial agents currently used for the reduction of inflammatory papules and cysts require frequent administration and are sometimes associated with uncomfortable side-effects contributing to a decrease in compliance. METHODS: Ninety-nine episodes of inflammatory acne in 79 patients treated with oral antimicrobial agents were studied retrospectively over a period of 46 weeks. Patients were treated with tetracycline, erythromycin, minocycline, and doxycycline, the most commonly prescribed oral antimicrobials used to treat acne. Individuals that were unable to tolerate this therapy or had failed conventional therapy were treated with the azalide antibiotic azithromycin, given in a single oral 250-mg dose three times a week. The other agents were administered daily in divided doses as is current practice. Patients were also on topical care. RESULTS: The efficacy and reported side-effects were examined for all agents. Significant improvement was noted in 4 weeks. All agents were effective in reducing inflammatory lesions and improving acne. Azithromycin produced a slightly higher percentage of patients with a greater than 80% reduction in their inflammatory acne lesions (85.7%) vs. an average of 77.1% for all other agents. All differences observed were not statistically significant. CONCLUSIONS: The results show that azithromycin is a safe and effective alternative in the treatment of inflammatory acne with few side-effects and good compliance, and suggest the need for further investigation with a clinical trial that will compare the long-term efficacy and tolerability. > > > I was on minocycline but when it seemed to lose its effectiveness, > I switched to > > doxcycline. You mention zithromax which I am not familiar with. > Is this a new > > drug for rosacea or one which has been around for awhile but is > less known than > > the tetracyclines? Do you take it every day and does it make you > photosensitive? > > a, Zithromax (azithromycin) is another type of antibiotic, a > variant of erythomycin. All antibiotics work by the same proposed > anti-inflammatory mechanism. Its chief benefit is that it is easier > to maintain a good blood level because it is taken only once a day > and isn't inactivated by dairy products or antacids. It also does not > cause photosensitivity, and can be taken on an empty stomach. The > downside is that it is quite expensive, far more so than even > doxycycline, and has more potential side effects than does the > tetracyclines (although it is still a relatively safe drug). The > erythromycins as a group are less effective in most rosaceans than > are the tetracycles/doxycyclines, but if doxycycline doesn't work for > you it is an option to discuss with your doctor, especially if it's > inconvenient to take pills every 12 hours. > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 For rosacea 500 mg zithro loading with 250mg qd thereafter is miles ahead of the others. But you should try minocyline first because that may work indefinately for you. At least try 100 mg Minocin or generic equivalent bid before graduating to Zithromax. Save Zithromax for when minocyline stops working or if you can't use Accutane. Int J Dermatol 2000 Jan;39(1):45-50 Related Articles, Books, LinkOut Azithromycin for the treatment of acne. Fernandez-Obregon AC. Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. BACKGROUND: Acne affects a large number of young adults, including women, who often present with facial as well as truncal involvement. Systemic antimicrobial agents currently used for the reduction of inflammatory papules and cysts require frequent administration and are sometimes associated with uncomfortable side-effects contributing to a decrease in compliance. METHODS: Ninety-nine episodes of inflammatory acne in 79 patients treated with oral antimicrobial agents were studied retrospectively over a period of 46 weeks. Patients were treated with tetracycline, erythromycin, minocycline, and doxycycline, the most commonly prescribed oral antimicrobials used to treat acne. Individuals that were unable to tolerate this therapy or had failed conventional therapy were treated with the azalide antibiotic azithromycin, given in a single oral 250-mg dose three times a week. The other agents were administered daily in divided doses as is current practice. Patients were also on topical care. RESULTS: The efficacy and reported side-effects were examined for all agents. Significant improvement was noted in 4 weeks. All agents were effective in reducing inflammatory lesions and improving acne. Azithromycin produced a slightly higher percentage of patients with a greater than 80% reduction in their inflammatory acne lesions (85.7%) vs. an average of 77.1% for all other agents. All differences observed were not statistically significant. CONCLUSIONS: The results show that azithromycin is a safe and effective alternative in the treatment of inflammatory acne with few side-effects and good compliance, and suggest the need for further investigation with a clinical trial that will compare the long-term efficacy and tolerability. > > > I was on minocycline but when it seemed to lose its effectiveness, > I switched to > > doxcycline. You mention zithromax which I am not familiar with. > Is this a new > > drug for rosacea or one which has been around for awhile but is > less known than > > the tetracyclines? Do you take it every day and does it make you > photosensitive? > > a, Zithromax (azithromycin) is another type of antibiotic, a > variant of erythomycin. All antibiotics work by the same proposed > anti-inflammatory mechanism. Its chief benefit is that it is easier > to maintain a good blood level because it is taken only once a day > and isn't inactivated by dairy products or antacids. It also does not > cause photosensitivity, and can be taken on an empty stomach. The > downside is that it is quite expensive, far more so than even > doxycycline, and has more potential side effects than does the > tetracyclines (although it is still a relatively safe drug). The > erythromycins as a group are less effective in most rosaceans than > are the tetracycles/doxycyclines, but if doxycycline doesn't work for > you it is an option to discuss with your doctor, especially if it's > inconvenient to take pills every 12 hours. > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 For rosacea 500 mg zithro loading with 250mg qd thereafter is miles ahead of the others. But you should try minocyline first because that may work indefinately for you. At least try 100 mg Minocin or generic equivalent bid before graduating to Zithromax. Save Zithromax for when minocyline stops working or if you can't use Accutane. Int J Dermatol 2000 Jan;39(1):45-50 Related Articles, Books, LinkOut Azithromycin for the treatment of acne. Fernandez-Obregon AC. Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. BACKGROUND: Acne affects a large number of young adults, including women, who often present with facial as well as truncal involvement. Systemic antimicrobial agents currently used for the reduction of inflammatory papules and cysts require frequent administration and are sometimes associated with uncomfortable side-effects contributing to a decrease in compliance. METHODS: Ninety-nine episodes of inflammatory acne in 79 patients treated with oral antimicrobial agents were studied retrospectively over a period of 46 weeks. Patients were treated with tetracycline, erythromycin, minocycline, and doxycycline, the most commonly prescribed oral antimicrobials used to treat acne. Individuals that were unable to tolerate this therapy or had failed conventional therapy were treated with the azalide antibiotic azithromycin, given in a single oral 250-mg dose three times a week. The other agents were administered daily in divided doses as is current practice. Patients were also on topical care. RESULTS: The efficacy and reported side-effects were examined for all agents. Significant improvement was noted in 4 weeks. All agents were effective in reducing inflammatory lesions and improving acne. Azithromycin produced a slightly higher percentage of patients with a greater than 80% reduction in their inflammatory acne lesions (85.7%) vs. an average of 77.1% for all other agents. All differences observed were not statistically significant. CONCLUSIONS: The results show that azithromycin is a safe and effective alternative in the treatment of inflammatory acne with few side-effects and good compliance, and suggest the need for further investigation with a clinical trial that will compare the long-term efficacy and tolerability. > > > I was on minocycline but when it seemed to lose its effectiveness, > I switched to > > doxcycline. You mention zithromax which I am not familiar with. > Is this a new > > drug for rosacea or one which has been around for awhile but is > less known than > > the tetracyclines? Do you take it every day and does it make you > photosensitive? > > a, Zithromax (azithromycin) is another type of antibiotic, a > variant of erythomycin. All antibiotics work by the same proposed > anti-inflammatory mechanism. Its chief benefit is that it is easier > to maintain a good blood level because it is taken only once a day > and isn't inactivated by dairy products or antacids. It also does not > cause photosensitivity, and can be taken on an empty stomach. The > downside is that it is quite expensive, far more so than even > doxycycline, and has more potential side effects than does the > tetracyclines (although it is still a relatively safe drug). The > erythromycins as a group are less effective in most rosaceans than > are the tetracycles/doxycyclines, but if doxycycline doesn't work for > you it is an option to discuss with your doctor, especially if it's > inconvenient to take pills every 12 hours. > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 > Int J Dermatol 2000 Jan;39(1):45-50 > > > Azithromycin for the treatment of acne. > > Fernandez-Obregon AC. > > Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. 007, this study is on acne, not rosacea -- two completely different conditions in which antibiotics are suspected to work in two different ways. Of course the two conditions can co-exist, but this study still has nothing to do with rosacea. Second, the study wasn't single-blinded much less double-blinded, placebo-controlled, multi- centered or anything else we look for in a good study. By the abstract it sounds like just an observational report, where Fernandez- Obregon knew which patients were on which antibiotics at all times. Typically, observational reports are funded by the drug company, for obvious reasons. Third, the bottom line is that they didn't find anything statistically significant. Fourth, the only good thing to come out of Hoboken, NJ was Sinatra. Seriously, that's not to say that azithromycin isn't helpful for some people with rosacea. It's just that this study has nothing to say about that, one way or the other. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 > Int J Dermatol 2000 Jan;39(1):45-50 > > > Azithromycin for the treatment of acne. > > Fernandez-Obregon AC. > > Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. 007, this study is on acne, not rosacea -- two completely different conditions in which antibiotics are suspected to work in two different ways. Of course the two conditions can co-exist, but this study still has nothing to do with rosacea. Second, the study wasn't single-blinded much less double-blinded, placebo-controlled, multi- centered or anything else we look for in a good study. By the abstract it sounds like just an observational report, where Fernandez- Obregon knew which patients were on which antibiotics at all times. Typically, observational reports are funded by the drug company, for obvious reasons. Third, the bottom line is that they didn't find anything statistically significant. Fourth, the only good thing to come out of Hoboken, NJ was Sinatra. Seriously, that's not to say that azithromycin isn't helpful for some people with rosacea. It's just that this study has nothing to say about that, one way or the other. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 > Int J Dermatol 2000 Jan;39(1):45-50 > > > Azithromycin for the treatment of acne. > > Fernandez-Obregon AC. > > Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. 007, this study is on acne, not rosacea -- two completely different conditions in which antibiotics are suspected to work in two different ways. Of course the two conditions can co-exist, but this study still has nothing to do with rosacea. Second, the study wasn't single-blinded much less double-blinded, placebo-controlled, multi- centered or anything else we look for in a good study. By the abstract it sounds like just an observational report, where Fernandez- Obregon knew which patients were on which antibiotics at all times. Typically, observational reports are funded by the drug company, for obvious reasons. Third, the bottom line is that they didn't find anything statistically significant. Fourth, the only good thing to come out of Hoboken, NJ was Sinatra. Seriously, that's not to say that azithromycin isn't helpful for some people with rosacea. It's just that this study has nothing to say about that, one way or the other. Marjorie Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 Well, it says what it says. It says that zithro is as safe as tetracyline, etc. essentially. Moreover we need to extract the following by logical reasoning. 1. They used a small dose of three 250 capsules per week, and this was essentially better (+/- statistical significance) than minocyline (200 mg/d), doxycyline (200 mg/d), eyrthromycin and tetracyline (both 1 g /d) -- this is in the text, etc. 2. The dose of minocyline of 200 mg/d generally produces great improvement in inflammatory rosacea. 3. If you use a REAL dose of 500 mg loading and 250 mg qd there after of zithromax, you will get a result much better than conventional current run of the mill therapy. IN OTHER WORDS A LOW DOSE OF ZITHRO IS AS EFFECTIVE AS FULL DOSE MINOCYLINE. IMAGINE WHAT A REAL DOSE OF ZITHRO WOULD DO Another study was explained in Dr. Nase's book in which it showed that a mere 250 mg bid clarithromycin was superior to 100 doxycycline bid. Don't have the cite at the top of my head. And I'm generally a fan of minocyline and previously thought it was better than zithromax. Now I know, clinically, backed by some research, that zithromax is better. Clinically, I would rate biaxin as less than minocyline. So in order of descending efficacy at full dosage: zithro, mino, clari, doxy, tetra, erythro. Incidentally, zithro and mino have high skin levels, and the newer macrolides cover for staph aureus, a common cause of papulopustular eruptions resistant to tetracyline therapy. 4. Inflammatory rosacea is very similar in regards to oral antibiotic therapy as acne therapy with oral antibiotics. Parrallelisms can be drawn. Therefore, a really good rosacea treatment, especially for inflammatory rosacea -- zithromax also being incidentally also just as safe as the other antibiotics. 5. If you want a double blinded study, multicentered, you're simply dreaming. This isn't going to happen anytime soon unless Bill Gates creates a rosacea foundation! Or someone on this list wins one of those pick the number lotteries. Anyone want to meet in Las Vegas??? Off label use is often where the best treatments hide gleaned for by deductive, logical reasoning. 6. Bottom line, if you want quick improvement, do the right antibiotic at the right dose. If you couldn't care less about when you'll improve, and if you enjoy a slow, methodical, tedious, stepwise approach, use 500 mg/d tetracyline --- oh, and don't plan any dates for a couple of months or any pressing social engagements in which you want/need your skin to look exceptionally well at. 7. Sinatra is good, you're right. > > > Int J Dermatol 2000 Jan;39(1):45-50 > > > > > > Azithromycin for the treatment of acne. > > > > Fernandez-Obregon AC. > > > > Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. > > 007, this study is on acne, not rosacea -- two completely different > conditions in which antibiotics are suspected to work in two > different ways. Of course the two conditions can co-exist, but this > study still has nothing to do with rosacea. Second, the study wasn't > single-blinded much less double-blinded, placebo-controlled, multi- > centered or anything else we look for in a good study. By the > abstract it sounds like just an observational report, where Fernandez- > Obregon knew which patients were on which antibiotics at all times. > Typically, observational reports are funded by the drug company, for > obvious reasons. Third, the bottom line is that they didn't find > anything statistically significant. Fourth, the only good thing to > come out of Hoboken, NJ was Sinatra. > > Seriously, that's not to say that azithromycin isn't helpful for some > people with rosacea. It's just that this study has nothing to say > about that, one way or the other. > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2002 Report Share Posted March 30, 2002 Well, it says what it says. It says that zithro is as safe as tetracyline, etc. essentially. Moreover we need to extract the following by logical reasoning. 1. They used a small dose of three 250 capsules per week, and this was essentially better (+/- statistical significance) than minocyline (200 mg/d), doxycyline (200 mg/d), eyrthromycin and tetracyline (both 1 g /d) -- this is in the text, etc. 2. The dose of minocyline of 200 mg/d generally produces great improvement in inflammatory rosacea. 3. If you use a REAL dose of 500 mg loading and 250 mg qd there after of zithromax, you will get a result much better than conventional current run of the mill therapy. IN OTHER WORDS A LOW DOSE OF ZITHRO IS AS EFFECTIVE AS FULL DOSE MINOCYLINE. IMAGINE WHAT A REAL DOSE OF ZITHRO WOULD DO Another study was explained in Dr. Nase's book in which it showed that a mere 250 mg bid clarithromycin was superior to 100 doxycycline bid. Don't have the cite at the top of my head. And I'm generally a fan of minocyline and previously thought it was better than zithromax. Now I know, clinically, backed by some research, that zithromax is better. Clinically, I would rate biaxin as less than minocyline. So in order of descending efficacy at full dosage: zithro, mino, clari, doxy, tetra, erythro. Incidentally, zithro and mino have high skin levels, and the newer macrolides cover for staph aureus, a common cause of papulopustular eruptions resistant to tetracyline therapy. 4. Inflammatory rosacea is very similar in regards to oral antibiotic therapy as acne therapy with oral antibiotics. Parrallelisms can be drawn. Therefore, a really good rosacea treatment, especially for inflammatory rosacea -- zithromax also being incidentally also just as safe as the other antibiotics. 5. If you want a double blinded study, multicentered, you're simply dreaming. This isn't going to happen anytime soon unless Bill Gates creates a rosacea foundation! Or someone on this list wins one of those pick the number lotteries. Anyone want to meet in Las Vegas??? Off label use is often where the best treatments hide gleaned for by deductive, logical reasoning. 6. Bottom line, if you want quick improvement, do the right antibiotic at the right dose. If you couldn't care less about when you'll improve, and if you enjoy a slow, methodical, tedious, stepwise approach, use 500 mg/d tetracyline --- oh, and don't plan any dates for a couple of months or any pressing social engagements in which you want/need your skin to look exceptionally well at. 7. Sinatra is good, you're right. > > > Int J Dermatol 2000 Jan;39(1):45-50 > > > > > > Azithromycin for the treatment of acne. > > > > Fernandez-Obregon AC. > > > > Hudson Dermatology & Skin Center, Hoboken, NJ 07030, USA. > > 007, this study is on acne, not rosacea -- two completely different > conditions in which antibiotics are suspected to work in two > different ways. Of course the two conditions can co-exist, but this > study still has nothing to do with rosacea. Second, the study wasn't > single-blinded much less double-blinded, placebo-controlled, multi- > centered or anything else we look for in a good study. By the > abstract it sounds like just an observational report, where Fernandez- > Obregon knew which patients were on which antibiotics at all times. > Typically, observational reports are funded by the drug company, for > obvious reasons. Third, the bottom line is that they didn't find > anything statistically significant. Fourth, the only good thing to > come out of Hoboken, NJ was Sinatra. > > Seriously, that's not to say that azithromycin isn't helpful for some > people with rosacea. It's just that this study has nothing to say > about that, one way or the other. > > Marjorie > > Marjorie Lazoff, MD Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2002 Report Share Posted March 31, 2002 007, I'm glad we agree on ol' blue eyes. Marjorie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2002 Report Share Posted March 31, 2002 007, I'm glad we agree on ol' blue eyes. Marjorie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 31, 2002 Report Share Posted March 31, 2002 007, I'm glad we agree on ol' blue eyes. Marjorie Quote Link to comment Share on other sites More sharing options...
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