CGRP antagonists - Why is this one website so far ahead of everyone else?

[Guest guest]

I did a little research on CGRP antagonists on the web. I didnt find a whole

lot, but I found this website at the U.S. patent office or something.

http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/\

netahtml/srchnum.htm&r=1&f=G&l=50&s1='5932215'.WKU.&OS=PN/5932215&RS=PN/5932215

Not sure if the link will work. Anyway, it talks about CGRP has been shown in

studies to be effective for treating cea and erythema for many of the

reasons that have already been discussed on here. It talks about how cea

has no cure, and how products like Metronidazole, antibiotics, etc, are

primarily ineffective at treating certain aspects of cea because they dont

go after the cause of the disorder. This patent talks about a topical

CGRP-blocker, possibly mixed with a substance-P blocker, or antiinflammatory

substances, or even with antibiotics. It seems like something that was actually

put together like this would blow every other cea treatment currently

available right out of the water. At the end they give seven examples of how to

make a succesful CGRP-blocking topical:

" EXAMPLE 1

Face cream (oil-in-water emulsion):

______________________________________

CGRP 8-37 0.5%

Glyceryl stearate 2%

Polysorbate 60 (Tween 60

1%

marketed by ICI)

Stearic acid 1.4%

Triethanolamine 0.7%

Carbomer 0.4%

Cyclomethicone 8%

Sunflower Oil 12%

Antioxidant 0.05%

Preservative 0.3%

Water qs 100%

EXAMPLE 5 Cream (oil-in-water emulsion):

______________________________________

Glyceryl stearate 2%

CGRP 8-37 0.02%

Polysorbate 60 (Tween 60

1%

marketed by ICI)

Stearic acid 1.4%

Metronidazole 0.5%

Triethanolamine 0.7%

Carbomer 0.4%

Cyclomethicone 8%

Sunflower oil 10%

Antioxidant 0.05%

Preservative 0.3%

Water qs 100%The website made it sound like the technology

already exists to make this happen, so my question is, why hasnt it happened

yet?Adam

[Guest guest]

>...The website made it sound like the technology already exists to

> make this happen, so my question is, why hasnt it happened yet?

Adam, narratives and formulations in this context are related to

gaining a patent. I didn't visit the site but from what I know,

securing a patent to an ingredient is one of the first, not one of

the last, steps in manufacturing and distributing a product. If it's

a drug, it also needs to be FDA approved, which is years of studies

for safety and efficacy.

Marjorie

Marjorie Lazoff, MD

> I did a little research on CGRP antagonists on the web. I didnt

find a whole lot, but I found this website at the U.S. patent office

or something.

>

> http://patft.uspto.gov/netacgi/nph-Parser?

Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=5

0&s1='5932215'.WKU.&OS=PN/5932215&RS=PN/5932215

>

> Not sure if the link will work. Anyway, it talks about CGRP has

been shown in studies to be effective for treating cea and

erythema for many of the reasons that have already been discussed on

here. It talks about how cea has no cure, and how products like

Metronidazole, antibiotics, etc, are primarily ineffective at

treating certain aspects of cea because they dont go after the

cause of the disorder. This patent talks about a topical CGRP-

blocker, possibly mixed with a substance-P blocker, or

antiinflammatory substances, or even with antibiotics. It seems like

something that was actually put together like this would blow every

other cea treatment currently available right out of the water.

At the end they give seven examples of how to make a succesful CGRP-

blocking topical:

>

> " EXAMPLE 1

>

> Face cream (oil-in-water emulsion):

>

>

> ______________________________________

> CGRP 8-37 0.5%

> Glyceryl stearate 2%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower Oil 12%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%

>

> EXAMPLE 5 Cream (oil-in-water emulsion):

______________________________________

> Glyceryl stearate 2%

> CGRP 8-37 0.02%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Metronidazole 0.5%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower oil 10%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%>

>

>

>

[Guest guest]

>...The website made it sound like the technology already exists to

> make this happen, so my question is, why hasnt it happened yet?

Adam, narratives and formulations in this context are related to

gaining a patent. I didn't visit the site but from what I know,

securing a patent to an ingredient is one of the first, not one of

the last, steps in manufacturing and distributing a product. If it's

a drug, it also needs to be FDA approved, which is years of studies

for safety and efficacy.

Marjorie

Marjorie Lazoff, MD

> I did a little research on CGRP antagonists on the web. I didnt

find a whole lot, but I found this website at the U.S. patent office

or something.

>

> http://patft.uspto.gov/netacgi/nph-Parser?

Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=5

0&s1='5932215'.WKU.&OS=PN/5932215&RS=PN/5932215

>

> Not sure if the link will work. Anyway, it talks about CGRP has

been shown in studies to be effective for treating cea and

erythema for many of the reasons that have already been discussed on

here. It talks about how cea has no cure, and how products like

Metronidazole, antibiotics, etc, are primarily ineffective at

treating certain aspects of cea because they dont go after the

cause of the disorder. This patent talks about a topical CGRP-

blocker, possibly mixed with a substance-P blocker, or

antiinflammatory substances, or even with antibiotics. It seems like

something that was actually put together like this would blow every

other cea treatment currently available right out of the water.

At the end they give seven examples of how to make a succesful CGRP-

blocking topical:

>

> " EXAMPLE 1

>

> Face cream (oil-in-water emulsion):

>

>

> ______________________________________

> CGRP 8-37 0.5%

> Glyceryl stearate 2%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower Oil 12%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%

>

> EXAMPLE 5 Cream (oil-in-water emulsion):

______________________________________

> Glyceryl stearate 2%

> CGRP 8-37 0.02%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Metronidazole 0.5%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower oil 10%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%>

>

>

>

[Guest guest]

>...The website made it sound like the technology already exists to

> make this happen, so my question is, why hasnt it happened yet?

Adam, narratives and formulations in this context are related to

gaining a patent. I didn't visit the site but from what I know,

securing a patent to an ingredient is one of the first, not one of

the last, steps in manufacturing and distributing a product. If it's

a drug, it also needs to be FDA approved, which is years of studies

for safety and efficacy.

Marjorie

Marjorie Lazoff, MD

> I did a little research on CGRP antagonists on the web. I didnt

find a whole lot, but I found this website at the U.S. patent office

or something.

>

> http://patft.uspto.gov/netacgi/nph-Parser?

Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=/netahtml/srchnum.htm&r=1&f=G&l=5

0&s1='5932215'.WKU.&OS=PN/5932215&RS=PN/5932215

>

> Not sure if the link will work. Anyway, it talks about CGRP has

been shown in studies to be effective for treating cea and

erythema for many of the reasons that have already been discussed on

here. It talks about how cea has no cure, and how products like

Metronidazole, antibiotics, etc, are primarily ineffective at

treating certain aspects of cea because they dont go after the

cause of the disorder. This patent talks about a topical CGRP-

blocker, possibly mixed with a substance-P blocker, or

antiinflammatory substances, or even with antibiotics. It seems like

something that was actually put together like this would blow every

other cea treatment currently available right out of the water.

At the end they give seven examples of how to make a succesful CGRP-

blocking topical:

>

> " EXAMPLE 1

>

> Face cream (oil-in-water emulsion):

>

>

> ______________________________________

> CGRP 8-37 0.5%

> Glyceryl stearate 2%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower Oil 12%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%

>

> EXAMPLE 5 Cream (oil-in-water emulsion):

______________________________________

> Glyceryl stearate 2%

> CGRP 8-37 0.02%

> Polysorbate 60 (Tween 60

> 1%

> marketed by ICI)

> Stearic acid 1.4%

> Metronidazole 0.5%

> Triethanolamine 0.7%

> Carbomer 0.4%

> Cyclomethicone 8%

> Sunflower oil 10%

> Antioxidant 0.05%

> Preservative 0.3%

> Water qs 100%>

>

>

>