Nicomide

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I have been using Nicomide for two months and have noticed an improvement in my

rosacea. My face is less irritated and the redness/blotchinees is diminished.

The improvement has been gradual and was not noticeable until I had been on

Nicomide for a good six weeks. Seeing your face daily, sometimes it is

difficult

to notice improvement. However, I was at the hairdressers yesterday for the

first

time in two months and noticed that my face looked fairly pale and the

blotchiness

was barely noticeable. The lights at the beauty shop are harsh and show

everything so I was pleased to notice the improvement.

For those interested, the insert in the Nicomide bottle contains the following

information:

Each tablet provides Nicotinamide 750 mg, Zinc Oxide 25 mg, and Folic Acid 500

mcg.

Indicated for non-pregnant patients with acne vulgaris, acne rosacea, or other

inflammatory skin disorders who are deficient in, or at risk of deficiency in,

one

or more of the components of Nicomide.

Nicotinamide has demonstrated anti-inflammatory actions which may be of benefit

in

patients with inflammatory acne vulgaris, including but not limited to,

suppression of antigen induced-lymphocytic transformation and inhibiition of

3'-5'

cyclic AMP phosphodiesterase. Nicotinamide has demonstrated the ability to

block

the inflammatory actions of iodides known to precipitate or exacerabe

inflammatory

acne. Nicotinamide lacks the vasodilator, gastrointestinal, heptic, and

hypolipemic actions of nicotinic acid (niacin). As such, nicotinamide has not

been shown to produce the flushing, itching and burning skin sensations commonly

observed when large doses of nicotinic acid are administered orally.

Zinc has been shown to inhibit inflammatory polymorphonuclear leukocyte

chemotaxis

in acne patients and on the lipase of the three Propionibacterium species found

in

human pilosebaceous follicles. Patients with inflammaortyr acnes have been

shown

to have significantly lower serum zinc levels than matched healthy controls.

Folic acid serves as an essential cofactor for the biosynthesis of thymidine and

purine nucleotides required for normal cellular DNA synthesis. Deficiencies of

folic acid have been demonstrated to occur in some cutaneous inflammatory

disorders.

Hope this is helpful.

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