The Pseudomonas aeruginosa genome

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The Pseudomonas aeruginosa genome How do we use it to

develop strategies for the treatment of patients with

cystic fibrosis and Pseudomonas infections?

Erwin AL, VanDevanter DR.

Curr Opin Pulm Med 2002 Nov;8(6):547-551

In the 2 years since the complete sequence of strain

PAO1 was published, at least 200 papers have been

published describing research that made use of the

PAO1 genome sequence. Some of this research included

genome-wide studies of gene expression or the effect

of mutation on bacterial functions such as biofilm

formation; this type of global analysis would not have

been possible without the availability of the

sequence. As a result of these and other, more

traditional, research studies, there is a wealth of

new knowledge about the physiology of this pathogen.

This raises the possibility of new strategies for the

treatment of patients with infection, either by novel

antibiotics or by drugs targeting bacterial functions

essential for survival and virulence in the human

host.

PMID: 12394165 [PubMed - as supplied by publisher]