Advances in Burkholderia cepacia complex

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Paediatric Respiratory Reviews

Volume 3, Issue 3, September 2002, Pages 230-235

Published by Elsevier Science Ltd. SERIES: NEW BIOLOGY OF THE AIRWAYS

Advances in Burkholderia cepacia complex

Speert

Division of Infectious and Immunological Diseases, Department of

Pediatrics, University of British Columbia and British Columbia's

Children's and Women's Health Centre and the Canadian Bacterial Diseases

Network, Room 377, Research Centre, 950 West 28th Avenue, Vancouver, BC,

V5Z 4H4, Canada

Available online 4 October 2002.

Abstract

Burkholderia cepacia is an important opportunistic pathogen in certain

compromised hosts, particularly those with either cystic fibrosis (CF) or

chronic granulomatous disease. The " family " of bacteria known as B.

cepacia is highly heterogeneous and is composed of at least nine discrete

species or genomovars, constituting the B. cepacia complex. Bacteria from

the B. cepacia complex are particularly virulent in susceptible hosts,

often causing necrotising invasive infection and death. Whereas the

microbial determinants of virulence in B. cepacia complex are currently

not defined, the bacteria appear to have features facilitating survival

within host cells. Burkholderia cepacia is highly resistant to

antibiotics and to neutrophil-mediated non-oxidative killing; infection

should be treated with combination antimicrobial therapy. Burkholderia

cepacia can spread from one CF patient to another. Transmission appears

to be facilitated by close personal contact and by certain bacterial

factors. Author Keywords: Burkholderia cepacia; Burkholderia cepacia

complex; cystic fibrosis; chronic granulomatous disease; epidemiology;

antibiotic resistance; quorum sensing; biofilms; multiple combination

antimicrobial testing

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Paediatric Respiratory Reviews

Volume 3, Issue 3, September 2002, Pages 230

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