Hearing loss through TOBI

[Guest guest]

Hi,

since someone asked about the risk of hearing loss in pwcf, you may

find this article helpful. The link will lead you to the full text

with even more information. In my opinion the risk is there, but it's

higher when you do IV-treatments with tobramycin.

Peace

Torsten

Occurrence and risk of cochleotoxicity in cystic fibrosis patients

receiving repeated high-dose aminoglycoside therapy.

Mulheran M, Degg C, Burr S, DW, Stableforth DE.

MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN,

United Kingdom. mm22@...

http://aac.asm.org/cgi/content/full/45/9/2502?view=full&pmid=11502521

Cystic fibrosis (CF) patients receive repeated courses of

aminoglycoside therapy. These patients would consequently be expected

to be more susceptible to cochleotoxicity, a recognized side effect

with single courses of aminoglycoside therapy. The primary aim of

this retrospective study was to establish the incidence and severity

of auditory deficit in CF patients. Standard (0.25- to 8-kHz) and

high-frequency (10- to 16-kHz) pure-tone audiometry was carried out

in 70 CF patients, and the results were compared with the results

from 91 control subjects. These subjects were further divided into

pediatric and adult groups. Of 70 CF patients, 12 (1 pediatric)

displayed hearing loss considered to be caused by repeated exposure

to aminoglycosides. There was a nonlinear relationship between the

courses of therapy received and the incidence of hearing loss. The

severity of the loss did not appear to be related to the number of

courses received. Assuming the risk of loss to be independent for

each course, preliminary estimates of per course risk of hearing loss

were less than 2%. Upon comparison with previous clinical studies and

experimental work, these findings suggest that the incidence of

cochleotoxicity in CF patients is considerably lower than would be

expected, suggesting that the CF condition may confer protection

against aminoglycoside cochleotoxicity.

PMID: 11502521 [PubMed - indexed for MEDLINE]

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