Fw: Budipine As Adjunct Therapy in PD

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Budipine As Adjunct Therapy in PD

> Budipine provides additional benefit in patients with parkinson disease

receiving a stable optimum dopaminergic drug regimen

> H Przuntek, S Bittkau, H Bliesath, U Büttner, G Fuchs, J Glass, H Haller,

T Klockgether, P Kraus, L Lachenmayer, D Müller, T Müller, B Rathay, J

Sgonina, V Steinijans, E Teshmar, G Ulm, D Volc

> Arch Neurol 2002;59:803-806

>

> Budipine is an effective adjunct treatment for Parkinson's disease,

according to this report. Budipine has a complex pharmacological profile

with actions on dopaminergic, GABAergic, cholinergic, norepinephrinergic,

and serotoninergic systems.

>

> Ninety-nine patients were randomized to receive placebo or budipine,

titrated up to 60 mg/day for 16 weeks. Patients were on stable levodopa and

bromocriptine treatment, with optional selegiline. Mean score on the

Columbia University Rating Scale fell from approximately 35 to 20 in the

treated group, versus 34 to 30 in the placebo group (p<0.001). Significant

differences between the two groups were obtained for tremor, rigidity, and

akinesia. Adverse events were significantly more common in the

budipine-treated group, and included dizziness, dry mouth, loss of appetite,

nervousness, and visual dysfunction.

>

> A previous report on budipine for PD tremor is archived at

> http://www.wemove.org/emove/article.asp?ID=109

>

>

> Copyright 2002 WE MOVE

> Editor: (rrobinson@...)

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