*GDNF and other information: Part Three www.shydrager.com

[Guest guest]

Interestingly, one of the links is: http://www.shydrager.com

Has this been discussed on the board? If so, I apologize for

repeating it. I accidently came across when I left the hypen out of

shy-drager.com Does anyone have thoughts about this site?

It has the following outline:

1.- Basic Research Articles

2.- Nutritional Medicine in MSA and Parskinson's Disease

3.- The causative factors (Aetiology) of MSA and PD

4.- Neurogenesis and Neurotrophic Factors and Therapies

5.- Main Symptoms MSA

6.- Respiratory problems

It also has a series of slides. And the following is a sample

research article.

NUTRITIONAL MEDICINE RESEARCH

UK

Selected sections from

Advances in Nutritional Medicine

June 1999, vol 10.

Food Biochemistry Reserach UK

A specially designed enriched environment for the induction of

neuronal regeneration in MSA-P, Shy-Drager Syndrome and Parkinson's

disease.

Grinstein

Biochemistry Research Institute

United Kingdom

RATIONALE TO ASSUME THAT NEURONAL REGENERATION CAN OCCUR THROUGH THE

ACTIVATION OF NEUROGENESIS

Neurogenesis is a novel term used to indicate that new neurons can be

generated in the central nervous system. This process has been

demonstrated to actually occur in the hippocampus of mice, monkeys

and humans. Experimental studies using bromodeoxyuridine as a marker

have demonstrated its incorporation into newly generated DNA showing

that DNA replication and neuronal division takes place in specific

areas of the brain. These results have been thoroughly confirmed in a

number of experimental studies that have eventually changed the

neuroscientist dogma stating that neurones can not replicate.

These results have raised interest in trying to establish methods to

modulate neuro-genesis because of its implications in developing

improved treatments for neuro-degenerative disorders like Multiple

System Atrophy (MSA) and Parkinson's disease.

Utilizing BDUR as a DNA marker it has been possible to demonstrate in

mice that neuro-genesis can be modulated through an enriched

environment. Mice living in this type of environment for a period of

100 days were able to activate the process of neurogenesis in the

hypothalamus. A 30% to 50% increase in the number of newly generated

neurones was found in mice living in this type of environment

compared to 10% to 15% of newly generated neurons in mice living in a

standard environment.

The main symptoms of Shy-Drager Syndrome, Parkinson's disease and MSA

appear after the depletion of specific neurotransmitters that are

necessary to send out signals for body movements or for the

functionality of the autonomic nervous system.

Medications that activate the biosynthesis of the neurotransmitter

dopamine, will produce a temporary relief in Parkinson's disease.

However, its continuous use, will gradually inhibit the endogenous

biosynthesis of this type of neurotransmitter. Increasing dosages of

these types of drugs are required after each year and the disease

progresses quickly at rates much higher than that of the natural

progression of the disease.

With the induction of neurogenesis, newly generated neurons will

actively synthesize the missing neurotransmitters and the symptoms of

the disease gradually disappear. Patients are able to function

normally, without requiring any form of medication for many hours

during the day, because a larger number of neuronal sites are now

actively synthesizing all the necessary neurotransmitters.

This normalization in biochemical brain activity can occur because of

two main well established processes. A.- Neuronal restoration; that

is when damaged neurons are able to repair themselves or B.-

Neurogenesis; that is when new neurons are generated in the damaged

areas of the nervous system.

A. - REPAIR OF DAMAGED NEURONS.

Our studies have demonstrated that specific dietary interventions can

enhance the secretion of brain neurotrophic factors. These factors

are secreted by glial cells, that are adjacent to neurons and secrete

factors that are necessary to maintain and provide nutrients and

repair neurons.

Neurotrophic factors, secreted by brain astrocytes (glial cells),

exert at least four types of action on the damaged or degenerating

nigrostriatal dopaminergic system.

1. - Protection against dopaminergic neurotoxins.

2. - Stimulation of neuronal growth or axonal sprouting.

3. - Stimulatory effect on the metabolism and function of

dopaminergic neurons.

4. - Increased Tyrosine Hydroxylase enzyme levels and dopamine

synthesis and turnover.

A wide number of neurotrophic factors secreted by glial cells have

been identified, characterized and shown to protect nigral dopamine

neurons:

1. Glial cell Derived Neurotrophic Factor, (GDNF).

2. Neurturin.

3. Basic fibroblast growth factor (bFGF).

4. Brain-derived neurotrophic factor (BDNF.

5. Neurotrophins 3 and 4/5.

6. Ciliary neurotrophic factor.

7. Transforming growth factor-â (beta).

B.- Generation of new neurons or Neurogenesis

An enriched living environment has been shown to stimulate

neurogenesis. Dietary interventions and exercise have also been shown

to stimulate the process of neurogenesis. This process has been

widely demonstrated to occur in experimental research with mice and

monkeys. Physical activity and exercising, practiced in conjunction

with specific dietary interventions, can stimulate neurogenesis in

humans. This can be easily observed in Parkinson's disease and MSA

patients, by measuring the gradual disappearance of disability.

To establish if a specific enriched environment could induce the

restoration of brain function and normalize neurotransmitter

biosynthesis, we have designed MSA and Parkinson's disease enriched

environment protocols, involving:

1.- dietary interventions,

2.- the use of glial cells regenerative factors like GCRF,

3.- nutritional adjustments and

4.- analytical chemistry studies relating to external environmental

factors to determine the etiology of the disease.

PET SCAN

A definitive answer to demonstrate clinically that new neurons have

been generated or damaged neurons have been repaired, can be provided

with the use of Positron Emission Tomography, PET scan.

PET scan has proved to be the most important tool yet devised for

experimental investigation of the living brain, whether healthy,

traumatized, or diseased.

PET scans are tomographic images, formed by computer analysis of

photons, detected from annihilation of positrons emitted by

radionuclides incorporated into biochemical substances. The images

often quantitfied with a colour scale, show the uptake and

distribution of the substances in the tissue, permitting analysis and

localization of metabolic and physiological function.

_______

Cheers,

Zac

[Guest guest]

Zac

We have seen that site before and have great reservations about the link to MSA

or Shy-Drager. Most of the studies are preliminery and refer to PD not SDS or

MSA. The main paper about MSA or SDS is in a journal which is not recognised as

a medical journal.

Scientific studies done in a double blind manner are usually supplied with free

supplements to test subjects, as far as we can tell this site sells the

supplements. I wish it was true, but I want to see results of a doubleblind

study published in a science journal before I would use it.

Take care, Bill Werre

-----------

>

>

> Date: 2002/07/15 Mon PM 07:37:52 CDT

> To: shydrager

> Subject: *GDNF and other information: Part Three www.shydrager.com

>

> Interestingly, one of the links is: http://www.shydrager.com

> Has this been discussed on the board? If so, I apologize for

> repeating it. I accidently came across when I left the hypen out of

> shy-drager.com Does anyone have thoughts about this site?

>

> It has the following outline:

> 1.- Basic Research Articles

>

> 2.- Nutritional Medicine in MSA and Parskinson's Disease

>

> 3.- The causative factors (Aetiology) of MSA and PD

>

> 4.- Neurogenesis and Neurotrophic Factors and Therapies

>

> 5.- Main Symptoms MSA

>

> 6.- Respiratory problems

>

> It also has a series of slides. And the following is a sample

> research article.

>

> NUTRITIONAL MEDICINE RESEARCH

> UK

>

> Selected sections from

> Advances in Nutritional Medicine

> June 1999, vol 10.

> Food Biochemistry Reserach UK

>

> A specially designed enriched environment for the induction of

> neuronal regeneration in MSA-P, Shy-Drager Syndrome and Parkinson's

> disease.

> Grinstein

> Biochemistry Research Institute

> United Kingdom

>

> RATIONALE TO ASSUME THAT NEURONAL REGENERATION CAN OCCUR THROUGH THE

> ACTIVATION OF NEUROGENESIS

> Neurogenesis is a novel term used to indicate that new neurons can be

> generated in the central nervous system. This process has been

> demonstrated to actually occur in the hippocampus of mice, monkeys

> and humans. Experimental studies using bromodeoxyuridine as a marker

> have demonstrated its incorporation into newly generated DNA showing

> that DNA replication and neuronal division takes place in specific

> areas of the brain. These results have been thoroughly confirmed in a

> number of experimental studies that have eventually changed the

> neuroscientist dogma stating that neurones can not replicate.

> These results have raised interest in trying to establish methods to

> modulate neuro-genesis because of its implications in developing

> improved treatments for neuro-degenerative disorders like Multiple

> System Atrophy (MSA) and Parkinson's disease.

> Utilizing BDUR as a DNA marker it has been possible to demonstrate in

> mice that neuro-genesis can be modulated through an enriched

> environment. Mice living in this type of environment for a period of

> 100 days were able to activate the process of neurogenesis in the

> hypothalamus. A 30% to 50% increase in the number of newly generated

> neurones was found in mice living in this type of environment

> compared to 10% to 15% of newly generated neurons in mice living in a

> standard environment.

>

> The main symptoms of Shy-Drager Syndrome, Parkinson's disease and MSA

> appear after the depletion of specific neurotransmitters that are

> necessary to send out signals for body movements or for the

> functionality of the autonomic nervous system.

> Medications that activate the biosynthesis of the neurotransmitter

> dopamine, will produce a temporary relief in Parkinson's disease.

> However, its continuous use, will gradually inhibit the endogenous

> biosynthesis of this type of neurotransmitter. Increasing dosages of

> these types of drugs are required after each year and the disease

> progresses quickly at rates much higher than that of the natural

> progression of the disease.

>

> With the induction of neurogenesis, newly generated neurons will

> actively synthesize the missing neurotransmitters and the symptoms of

> the disease gradually disappear. Patients are able to function

> normally, without requiring any form of medication for many hours

> during the day, because a larger number of neuronal sites are now

> actively synthesizing all the necessary neurotransmitters.

> This normalization in biochemical brain activity can occur because of

> two main well established processes. A.- Neuronal restoration; that

> is when damaged neurons are able to repair themselves or B.-

> Neurogenesis; that is when new neurons are generated in the damaged

> areas of the nervous system.

>

> A. - REPAIR OF DAMAGED NEURONS.

> Our studies have demonstrated that specific dietary interventions can

> enhance the secretion of brain neurotrophic factors. These factors

> are secreted by glial cells, that are adjacent to neurons and secrete

> factors that are necessary to maintain and provide nutrients and

> repair neurons.

> Neurotrophic factors, secreted by brain astrocytes (glial cells),

> exert at least four types of action on the damaged or degenerating

> nigrostriatal dopaminergic system.

> 1. - Protection against dopaminergic neurotoxins.

> 2. - Stimulation of neuronal growth or axonal sprouting.

> 3. - Stimulatory effect on the metabolism and function of

> dopaminergic neurons.

> 4. - Increased Tyrosine Hydroxylase enzyme levels and dopamine

> synthesis and turnover.

>

> A wide number of neurotrophic factors secreted by glial cells have

> been identified, characterized and shown to protect nigral dopamine

> neurons:

> 1. Glial cell Derived Neurotrophic Factor, (GDNF).

> 2. Neurturin.

> 3. Basic fibroblast growth factor (bFGF).

> 4. Brain-derived neurotrophic factor (BDNF.

> 5. Neurotrophins 3 and 4/5.

> 6. Ciliary neurotrophic factor.

> 7. Transforming growth factor-â (beta).

>

> B.- Generation of new neurons or Neurogenesis

> An enriched living environment has been shown to stimulate

> neurogenesis. Dietary interventions and exercise have also been shown

> to stimulate the process of neurogenesis. This process has been

> widely demonstrated to occur in experimental research with mice and

> monkeys. Physical activity and exercising, practiced in conjunction

> with specific dietary interventions, can stimulate neurogenesis in

> humans. This can be easily observed in Parkinson's disease and MSA

> patients, by measuring the gradual disappearance of disability.

> To establish if a specific enriched environment could induce the

> restoration of brain function and normalize neurotransmitter

> biosynthesis, we have designed MSA and Parkinson's disease enriched

> environment protocols, involving:

> 1.- dietary interventions,

> 2.- the use of glial cells regenerative factors like GCRF,

> 3.- nutritional adjustments and

> 4.- analytical chemistry studies relating to external environmental

> factors to determine the etiology of the disease.

>

> PET SCAN

> A definitive answer to demonstrate clinically that new neurons have

> been generated or damaged neurons have been repaired, can be provided

> with the use of Positron Emission Tomography, PET scan.

> PET scan has proved to be the most important tool yet devised for

> experimental investigation of the living brain, whether healthy,

> traumatized, or diseased.

> PET scans are tomographic images, formed by computer analysis of

> photons, detected from annihilation of positrons emitted by

> radionuclides incorporated into biochemical substances. The images

> often quantitfied with a colour scale, show the uptake and

> distribution of the substances in the tissue, permitting analysis and

> localization of metabolic and physiological function.

>

>

> _______

>

> Cheers,

>

> Zac

>

>

>

>

>

>

>

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

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