Guest guest Posted July 19, 2002 Report Share Posted July 19, 2002 The 8th International Conference on Alzheimer's and Related Disorders is being held in Stockholm from July 20 to 25. You might ask " so what? " I learned of this conference as both of Terry's docs are attending and one is delivering a paper. I have scanned the program at http://www.alz.org/internationalconference/programs.htm and find it to be of broad interest in the arena of nuero-degenerative disease processes, especially dementia. The latter, dementia, has recently been added on a preliminary basis to Terry's Dx. We are exploring this further with her new neurologist. In any events, some folks may find scanning the program to be of interest. PS As a sidelight, both of Terry's docs, one neurologist and one neuropsychologist, are Co Directors of the Memory Disorders Clinic in the Neurology Department at the University of Virginia. This Clinic also includes on movement disorder specialist, who is not nearly as broad in the neurological outlook as the Co Directors. The message I have gotten is that you neurologists with a broad behavioral background for folks with MSA, PSP, DLBD, etc. Note that PD is not explicitly included. Terry original saw the movement disorder specialist at UVa and he was baffled by her case and referred her to the Co Director of this Clinic. We are glad for his referral.The medical support has been much better ever since the referral. Sennewald Charlottesville, Virginia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 19, 2002 Report Share Posted July 19, 2002 , Actually dementia is very associated with PD and LBD (and the tau disorders like PSP and CBGD) more so than MSA. In MSA the cognitive functions are more affected as Fisher and others have pointed out - it is not memory but the analyzing portion of the brain which seems to have problems. In fact as the PD patient gets older, they are very likely to have at least some dementia. I don't remember the exact figures but by 60 something like 10% of the PD patients had some form of dementia, by 70 y.o. up to about 30% and by 80-90 it was very high. Am I miss-reading your email? You seem to be saying just the opposite. The first neurologist who saw Charlotte and diagnosed her as PD was more into Altzheimers than the movement disorder specialists we later went to, but she was not as good at working with specific symptoms and adjusting meds. Charlotte had no memory problems except when she had infection. However, she could not process info (like driving) well at all and felt the road was closing in on her. But the night before she died, she told us not to put the trash out because the Town does not pick up trash the day after Thanksgiving. That sort of mental capability seems to be standard for MSA as many report the same thing - slowed analyzation, but memory is fine. Take care, Bill Werre ======================================= > > > Date: 2002/07/19 Fri AM 08:42:43 CDT > To: shydrager > Subject: Conference in Sweden > > The 8th International Conference on Alzheimer's and Related Disorders is > being held in Stockholm from July 20 to 25. > > You might ask " so what? " > > I learned of this conference as both of Terry's docs are attending and one > is delivering a paper. I have scanned the program at > > http://www.alz.org/internationalconference/programs.htm > > and find it to be of broad interest in the arena of nuero-degenerative > disease processes, especially dementia. The latter, dementia, has recently > been added on a preliminary basis to Terry's Dx. We are exploring this > further with her new neurologist. > > In any events, some folks may find scanning the program to be of interest. > > PS As a sidelight, both of Terry's docs, one neurologist and one > neuropsychologist, are Co Directors of the Memory Disorders Clinic in the > Neurology Department at the University of Virginia. This Clinic also > includes on movement disorder specialist, who is not nearly as broad in the > neurological outlook as the Co Directors. The message I have gotten is > that you neurologists with a broad behavioral background for folks with > MSA, PSP, DLBD, etc. Note that PD is not explicitly included. Terry > original saw the movement disorder specialist at UVa and he was baffled by > her case and referred her to the Co Director of this Clinic. We are glad > for his referral.The medical support has been much better ever since the > referral. > > Sennewald Charlottesville, Virginia > > > > If you do not wish to belong to shydrager, you may > unsubscribe by sending a blank email to > > shydrager-unsubscribe > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 19, 2002 Report Share Posted July 19, 2002 Thanks , I remembered reading abstracts from this group's last conference that included lots of research on the synuclein protein (implicated as a possible cause of MSA) so I just scanned for that among their abstracts on the website you provided. Some of theme look especially relevant to MSA and the other parkinson-plus disorders. These presentations appear to deal with understanding the function of alpha-synuclein and why alpha-synuclein forms aggregates in brain cells and also look at ways to inhibit(or stop) this aggregation ie. potential future treatments. It's really interesting to see where in the world these researchers are working. Lots going on in Japan, China and Europe. ARE ?-SYNUCLEIN DERIVATIVES AN ALTERNATIVE APPROACH FOR TREATMENT OF NEURODEGENERATIVE DISORDERS Manfred Windisch1, Eliezer Masliah2, Rockenstein2, Birgit Hutter-Paier1 1JSW-Research GmbH, Rankengasse 28, Graz, A-8020, Styria, Austria; 2University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, California, United States Session: Synucleins - P3 INHIBITION AND MECHANISM OF ALPHA-SYNUCLEIN AGGREGATION Zagorski1, Mihaela Apetri1, Vernon 2 1Case Western Reserve University, Dept of Chemistry, Cleveland, 44106-7078, Ohio, United States; 2Case Western Reserve University, Dept of Biohemistry, Cleveland, 44106, Ohio, United States Session: Lewy-body related diseases - P4 THE DUAL EFFECTS OF a-SYNUCLEIN ON THE NEURONAL SURVIVAL Ji-Heui Seo, Jong-Cheol Rah, Se Hoon Choi, Jae Kyung Shin, KyoungSik Min, Yoo-Hun Suh Coll. of Medicine, Seoul National University, Dept. of Pharmacology, 28 Yongon-dong, Chongno-gu, Seoul, 110-799, Republic of Korea Session: Alzheimers disease - P3 INHIBITION OF a-SYNUCLEIN(68-78) AGGREGATION AND TOXICITY BY AN N-METHYLATED ANALOGUE G Brent Irvine1, M Bodles1, Brett Greer1, M A El-Agnaf2, J S Guthrie1 1Queen's University Belfast, School of Biology & Biochemistry, Belfast, BT9 7BL, United Kingdom; 2Lancaster University, School of Biological Sciences, Lancaster, LA1 4YQ, United Kingdom Session: Synucleins - P3 alpha-SYNUCLEIN, ESPECIALLY THE PARKINSON'S DISEASE-ASSOCIATED MUTANTS, FORMS PORE-LIKE ANNULAR AND TUBULAR PROTOFIBRILS Hilal Lashuel1, Petre2, ph Wall3, Martha Simon3, Nowak1, Walz2, Lansbury1 1Brigham and Women's Hospital/Harvard Medical School, 65 Landsdowne St, Cambridge, 02139, Massachusetts, United States; 2Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, 02115, Massachusetts, United States; 3Department of Biology, Brookhaven National Laboratory, building 463, Upton, 11973, New York, United States Session: Synucleins - P3 NEURODEGENERATION IN ALPHA-SYNUCLEIN TRANSGENIC MICE IS ASSOCIATED WITH ACCUMULATION OF TRUNCATED ALPHA-SYNUCLEIN POLYPEPTIDES Lee1, Wanda Stirling1, Yanqun Xu1, Neal Copeland2, Nacy 2, Price1 1s Hopkins University, School of Medicine, Dept of Pathology, Ross 558, Baltimore, 21205, land, United States; 2NCI, Mammalian Genetic Laboratory, Frederick, 21702, land, United States Session: Animal & Cellular Models Transgenic - S8 ALPHA-SYNUCLEIN (A-SYN) AS A REGULATOR OF DOPAMINE SYNTHESIS Ruth 1, Jack Waymire2, Eva Lin1, Fengli Guo3, Zigmond1 1University of Pittsburgh School of Medicine, Department of Neurology, Pittsburgh, 15213, Pennsylvania, United States; 2University of Texas Medical School, Department of Neurobiology & Anatomy, Houston, 77330, Texas, United States; 3University of Pittsburgh School of Medicine, Center for Biological Imaging, Pittsburgh, 15213, Pennsylvania, United States Session: Related neurodegenerative conditions - S6 TWO PARKINSON'S DISEASE-LINKED PROTEINS, a-SYNUCLEIN AND PARKIN, INTERACT IN NORMAL HUMAN BRAIN Schlossmacher1, Hideki Shimura1, Frosch1, Wei Ping Gai2, Nobutaka Hattori3, Yoshikuni Mizuno3, Kosik1, Dennis Selkoe1 1Center for Neurologic Diseases, Harvard Medical School, 77 Ave Louis Pasteur, Boston, 02115, MA, United States; 2Centre for Neuroscience, Flinders University, Flinders University, Bedford Park, Australia; 3Department of Neurology, Juntendo University Medical School, Juntendo University, Tokyo, Japan Session: Lewy-body related diseases - P4 SYNUCLEIN PROFILE IN APP23 TRANSGENIC MICE Feldmann1, Oliver Wirths1, Matthias Staufenbiel2, Gerd Multhaup3, Konrad Beyreuther4, Bayer1 1University of Bonn, Medical Center, Sigmund-Freud-Str.25, Bonn, 53105, NRW, Germany; 2Nervous System Research, Novartis Pharma Inc., Klybachstr.141, Basel, 4057, Basel, Switzerland; 3ZMBH Heidelberg, Im Neuenheimer Feld 282, Heidelberg, 69120, Germany; 4ZMBH Heidelberg, Im Neuenheimer Feld 282, Heidelberg, 69120, Basel, Germany Session: Synucleins - P3 MOLECULAR CLONING OF A COMPLIMENTARY DNA ENCODING A NOVEL PROTEIN THAT INTERACTS WITH ALPHA-SYNUCLEIN Qiulan Ma1, M Abdul Alim1, M Shahanara Hossain1, Takako Aizawa1, Kunimasa Arima2, Piu Chan3, Mitsunobu Yoshii1, Kenji Ueda1 1Department of Neural Plasticity, Tokyo Inst Psychiatry, 2-1-8 Kamikitazawa, Setagaya, Tokyo, 156-8585, Japan; 2Department of Lab Med, NCHMNMD, NCNP, 4-1-1 Ogawahigashi, Kodaira, 187-8551, Tokyo, Japan; 3The Sino-Japan Joint Lab on Neurodegenerative Diseases, Beijing Inst Geriatrics, Xuanwu Hosptl, Capital Univ Med Sciences, 45 Chang Chun Street, Xuan Wu District, Beijing, 100053, China Session: Synucleins - P3 ------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 19, 2002 Report Share Posted July 19, 2002 Message: 3 Date: Fri, 19 Jul 2002 9:03:38 -0500 Subject: Re: Conference in Sweden Bill: The addition of dementia to the Dx is new by the new neurologist and we need to spend more time to understand his basis for this addition. Terry's memory and general cognitive skills are not bad as long as we stick to single tasking without a lot of other confusing inputs. When her new nuero gets backs from Sweden, I plan to follow up with him on his perspective on Terry. I had a lot to digest in our first appointment. He also added " psuedo PSP to the Dx mix, so we have a lot of ground to cover. He comes with good credentials and I am quite impressed with his approach and knowledge in our first encounter. Another nuero in the department thinks her Dx is FTD. Also, the new nuero had not had a chance to see the results of the SPECT scan done last October. So we have some work to do. , Actually dementia is very associated with PD and LBD (and the tau disorders like PSP and CBGD) more so than MSA. In MSA the cognitive functions are more affected as Fisher and others have pointed out - it is not memory but the analyzing portion of the brain which seems to have problems. In fact as the PD patient gets older, they are very likely to have at least some dementia. I don't remember the exact figures but by 60 something like 10% of the PD patients had some form of dementia, by 70 y.o. up to about 30% and by 80-90 it was very high. Am I miss-reading your email? You seem to be saying just the opposite. The first neurologist who saw Charlotte and diagnosed her as PD was more into Altzheimers than the movement disorder specialists we later went to, but she was not as good at working with specific symptoms and adjusting meds. Charlotte had no memory problems except when she had infection. However, she could not process info (like driving) well at all and felt the road was closing in on her. But the night before she died, she told us not to put the trash out because the Town does not pick up trash the day after Thanksgiving. That sort of mental capability seems to be standard for MSA as many report the same thing - slowed analyzation, but memory is fine. Take care, Bill Werre Sennewald Charlottesville, Virginia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 19, 2002 Report Share Posted July 19, 2002 , I understand the PSP ) BUT you state FTD - to me that is Floral Telegraph Delivery ) I did did give Charlotte that at times as well as Anne Pledger and Ford ) But I thought it was flowers and not a brain disorder ) Hey do you want to get together in August? It will be near the Moller's if not at their home. Take care, Bill Werre > another nuero in the department thinks > her Dx is FTD. Also, the new nuero had not had a chance to see the results > of the SPECT scan done last October. So we have some work to do. > > , > > > Actually dementia is very associated with PD and LBD (and the tau disorders > like PSP and CBGD) more so than MSA. In MSA the cognitive functions are > more affected as Fisher and others have pointed out - it is not memory > but the analyzing portion of the brain which seems to have problems. > > > In fact as the PD patient gets older, they are very likely to have at least > some dementia. I don't remember the exact figures but by 60 something like > 10% of the PD patients had some form of dementia, by 70 y.o. up to about > 30% and by 80-90 it was very high. > > > Am I miss-reading your email? You seem to be saying just the > opposocs.yahoo.com/info/terms/ > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 20, 2002 Report Share Posted July 20, 2002 FTD is Frontotemporal dementia. http://www.alzwisc.org/frontotemporaldem.html Re: Re: Conference in Sweden > , > > I understand the PSP ) BUT you state FTD - to me that is Floral Telegraph Delivery ) I did did give Charlotte that at times as well as Anne Pledger and Ford ) But I thought it was flowers and not a brain disorder ) > > Hey do you want to get together in August? It will be near the Moller's if not at their home. > > Take care, Bill Werre > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 20, 2002 Report Share Posted July 20, 2002 Bill: You must be pulling my leg . FTD I believe is Frontal temporal dementia. At the moment August looks good on any Sunday. Message: 14 Date: Fri, 19 Jul 2002 23:29:02 -0500 Subject: Re: Re: Conference in Sweden , I understand the PSP ) BUT you state FTD - to me that is Floral Telegraph Delivery ) I did did give Charlotte that at times as well as Anne Pledger and Ford ) But I thought it was flowers and not a brain disorder ) Hey do you want to get together in August? It will be near the Moller's if not at their home. Take care, Bill Werre > another nuero in the department thinks > her Dx is FTD. Also, the new nuero had not had a chance to see the results > of the SPECT scan done last October. So we have some work to do. > > , > Sennewald Charlottesville, Virginia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 20, 2002 Report Share Posted July 20, 2002 Pam: Thanks for the clarification. Based on that page, more credence may have to be given to the FTD Dx by Terry's original neurologist. As you may recall from an earlier post, her new nuero - this is no. 3, no. 2 left UVa, and no. 1 referred her to no. 2 - has a little different twist on her Dx; he is saying in initial appointment MSA/SND with psuedo PSP[whatever that means], and dementia. As I told Bill, I have some more work to do with no. 3 nuero when he returns from Stockholm. Maybe it is one part FTD and one part PSP and two parts MSA/SND. That goes along with your Neapolitan ice cream metaphor. I am confident nuero no. 3 is quite competent based on initial meeting. Thanks again. Message: 3 Date: Sat, 20 Jul 2002 09:05:38 -0300 Subject: Re: Re: Conference in Sweden FTD is Frontotemporal dementia. http://www.alzwisc.org/frontotemporaldem.html Re: Re: Conference in Sweden > , > > I understand the PSP ) BUT you state FTD - to me that is Floral Telegraph Delivery ) I did did give Charlotte that at times as well as Anne Pledger and Ford ) But I thought it was flowers and not a brain disorder ) > > Hey do you want to get together in August? It will be near the Moller's if not at their home. > > Take care, Bill Werre > Sennewald Charlottesville, Virginia Quote Link to comment Share on other sites More sharing options...
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