Re: RESEARCH: The nature of the autonomic dysfunction in multiple system a

[Guest guest]

Pam,

NASA has evidently done some work on this.

Baroreflex

A baroreflex is a reflex triggered by the stimulation of a baroreceptor (a

collection of sensory nerve endings in the wall of the heart auricles, vena

cava, aortic arch and carotid sinuses that are specialized to monitor changes in

blood pressure). The baroreflex acts to increase or decrease the blood pressure

to maintain a stable blood pressure within the body.

Take care, Bill Werre

>

>

> Date: 2002/07/20 Sat AM 07:24:37 CDT

> To: " sds " shydrager >

> Subject: RESEARCH: The nature of the autonomic dysfunction in multiple

system atrophy

>

> Now this is interesting.... " possible development of a bionic baroreflex for

> better control of blood pressure. " I have no idea exactly what a bionic

> baroreflex is but it sounds like an implant.

>

> Regards,

> Pam

>

> -----------------

>

> The nature of the autonomic dysfunction in multiple system atrophy

>

> Samir M. Parikh, André Diedrich, Italo Biaggioni and on,

>

> Autonomic Dysfunction Center, Departments of Medicine, Pharmacology and

> Neurology, Vanderbilt University, AA 3228 MCN, Nashville, TN 37232-2195, USA

>

> Received 26 November 2001; revised 29 March 2002; accepted 29 April 2002.

> Available online 4 June 2002.

>

>

>

> Abstract

> The concept that multiple system atrophy (MSA, Shy-Drager syndrome) is a

> disorder of the autonomic nervous system is several decades old. While there

> has been renewed interest in the movement disorder associated with MSA, two

> recent consensus statements confirm the centrality of the autonomic disorder

> to the diagnosis. Here, we reexamine the autonomic pathophysiology in MSA.

> Whereas MSA is often thought of as " autonomic failure " , new evidence

> indicates substantial persistence of functioning sympathetic and

> parasympathetic nerves even in clinically advanced disease. These findings

> help explain some of the previously poorly understood features of MSA.

> Recognition that MSA entails persistent, constitutive autonomic tone

> requires a significant revision of our concepts of its diagnosis and

> therapy. We will review recent evidence bearing on autonomic tone in MSA and

> discuss their therapeutic implications, particularly in terms of the

> possible development of a bionic baroreflex for better control of blood

> pressure.

>

>

>

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