RESEARCH: Cerebral metabolic changes in early multiple system atrophy: a PET study.

[Guest guest]

J Neurol Sci 2002 Aug 15;200(1-2):79-84

Cerebral metabolic changes in early multiple system atrophy: a PET study.

Taniwaki T, Nakagawa M, Yamada T, Yoshida T, Ohyagi Y, Sasaki M, Kuwabara Y,

Tobimatsu S, Kira J.

Department of Neurology, Graduate School of Medical Sciences, Kyushu

University,

3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan

Previous positron emission tomography (PET) studies have shown widespread

hypometabolism in the brain of advanced MSA but the time course of these

metabolic abnormalities is largely unknown. In order to clarify the

principal

disease processes in multiple system atrophy (MSA) in the early stage, we

investigated regional cerebral glucose metabolism (rCMGglc) and nigral

dopaminergic function in nine patients with early stage of MSA using

[18F]fluorodeoxyglucose (FDG) and 6-L-[18F]fluorodopa (18F-Dopa) positron

emission tomography (PET) (two men and seven women; age, 59.3+/-5.4 years;

disease duration, 29.7+/-14.6 months). The rCMRglc in the early MSA patients

significantly decreased in the cerebellum, brainstem, and striatum compared

with

that in nine normal subjects. A significant correlation was found between

the

severity of autonomic dysfunction and rCMRglc within the brainstem. The

severity

of extrapyramidal signs also correlated with the decline of F-Dopa uptake

but

not that of rCMRglc within the striatum. The degree of atrophy on MRI has

correlated with neither the clinical symptoms nor rCMRglc at the cerebellum

and

the brainstem. Our PET studies demonstrated widespread metabolic

abnormalities

except for the cerebral cortex in the brain of MSA even in the early stage.

The

hypometabolism in the brainstem was tightly linked to the autonomic

dysfunction.

Not the striatal dysfunction but the nigral damage may be responsible for

the

extrapyramidal symptoms in early MSA.

PMID: 12127681 [PubMed - in process]

[Guest guest]

Pam,

Thank you for this information. It almost made me cry as this study

points more toward the " Probable PSP " diagnosis that the doctor told us

about. I had just gotten to the point of accepting the MSA:SND

diagnosis.... never dreamed of PSP and all the other " bonus " problems with

my brain.

Hugs,

Deborah

_______________________________________________________________________

J Neurol Sci 2002 Aug 15;200(1-2):79-84

Cerebral metabolic changes in early multiple system atrophy: a PET study.

Taniwaki T, Nakagawa M, Yamada T, Yoshida T, Ohyagi Y, Sasaki M, Kuwabara Y,

Tobimatsu S, Kira J.

Department of Neurology, Graduate School of Medical Sciences, Kyushu

University,

3-1-1 Maidashi, Higashi-ku, 812-8582, Fukuoka, Japan

Previous positron emission tomography (PET) studies have shown widespread

hypometabolism in the brain of advanced MSA but the time course of these

metabolic abnormalities is largely unknown. In order to clarify the

principal

disease processes in multiple system atrophy (MSA) in the early stage, we

investigated regional cerebral glucose metabolism (rCMGglc) and nigral

dopaminergic function in nine patients with early stage of MSA using

[18F]fluorodeoxyglucose (FDG) and 6-L-[18F]fluorodopa (18F-Dopa) positron

emission tomography (PET) (two men and seven women; age, 59.3+/-5.4 years;

disease duration, 29.7+/-14.6 months). The rCMRglc in the early MSA patients

significantly decreased in the cerebellum, brainstem, and striatum compared

with

that in nine normal subjects. A significant correlation was found between

the

severity of autonomic dysfunction and rCMRglc within the brainstem. The

severity

of extrapyramidal signs also correlated with the decline of F-Dopa uptake

but

not that of rCMRglc within the striatum. The degree of atrophy on MRI has

correlated with neither the clinical symptoms nor rCMRglc at the cerebellum

and

the brainstem. Our PET studies demonstrated widespread metabolic

abnormalities

except for the cerebral cortex in the brain of MSA even in the early stage.

The

hypometabolism in the brainstem was tightly linked to the autonomic

dysfunction.

Not the striatal dysfunction but the nigral damage may be responsible for

the

extrapyramidal symptoms in early MSA.

PMID: 12127681 [PubMed - in process]

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