Environmental Toxins Research >Pam

[Guest guest]

Hi Pam:

I was reading your file on Environmental Toxins Research. I came across this the other night. I can remember where I found it, but do remember it was dated 98. I wonder if you had seen this also?

Take Care

Vera

Environmental-occupational risk factors and familial associations in multiple system atrophy: a preliminary investigation.

Clin Auton Res 1(1): 9-13.

We studied 60 patients with multiple system atrophy and autonomic failure and 60 control subjects matched for age, sex and race. Their psychosocial history, pedigree and occupation were obtained by personal interview. An inventory of autonomic and neurologic symptoms was obtained from 148 first-degree relatives of the patients and 80 controls by a self-administered questionnaire. Patients with multiple system atrophy had significantly more potential exposures to metal dusts and fumes, plastic monomers and additives, organic solvents, and pesticides than the control population. The potential exposures were determined in most subjects by their reported usual occupation. Clinical symptoms of multiple system atrophy were reported by a significantly larger group of patients' relatives than controls. These findings are possibly consistent with the hypothesis that multiple system atrophy develops as a result of a genetically determined selective vulnerability in the nervous system. Specific neuronal systems may become targets for environmental insults or toxins, and the disease state may occur when ageing neuronal systems can no longer sustain functional capacity. This preliminary study supports the need to further explore possible environmental, occupational, and familial contributions to the aetiology of multiple system atrophy.

[Guest guest]

Hi Vera,

I hadn't seen that one but just found it in Pubmed. It's from 1991.

Clin Auton Res 1991 Mar;1(1):9-13

Environmental-occupational risk factors and familial associations in multiple system atrophy: a preliminary investigation.Nee LE, Gomez MR, Dambrosia J, Bale S, Eldridge R, Polinsky RJ.Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

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There was another study by Hanna & Jankovic done in 1999.

The abstract is here:

http://archneur.ama-assn.org/issues/v56n1/abs/noc7799.html

The full text is saved here:

http://groups.yahoo.com/group/shydrager/files/Msa.doc

I had also saved these two articles published in 2000:

Carbon Disulphide and MSA Environmental Health Perspectives Volume 108, Number 3, March 2000 http://ehpnet1.niehs.nih.gov/docs/2000/108-3/correspondence.html

Parkinson's Linked to Pesticides NewsMax.com November 7, 2000 http://www.newsmax.com/archives/articles/2000/11/7/140757.shtml

As we've said on the list many times there has been no definitive study yet on whether there is a link between pesticide exposure and Multiple System Atrophy. I believe this is another thing Dr.Shults and his group will be looking into further once their MSA study gets underway.

Hugs,

Pam

-----Original Message-----From: FVJAMES@... Sent: Tuesday, August 06, 2002 12:59 PMTo: shydrager Subject: Environmental Toxins Research >PamHi Pam:I was reading your file on Environmental Toxins Research. I came across this the other night. I can remember where I found it, but do remember it was dated 98. I wonder if you had seen this also? Take Care VeraEnvironmental-occupational risk factors and familial associations in multiple system atrophy: a preliminary investigation.Clin Auton Res 1(1): 9-13.We studied 60 patients with multiple system atrophy and autonomic failure and 60 control subjects matched for age, sex and race. Their psychosocial history, pedigree and occupation were obtained by personal interview. An inventory of autonomic and neurologic symptoms was obtained from 148 first-degree relatives of the patients and 80 controls by a self-administered questionnaire. Patients with multiple system atrophy had significantly more potential exposures to metal dusts and fumes, plastic monomers and additives, organic solvents, and pesticides than the control population. The potential exposures were determined in most subjects by their reported usual occupation. Clinical symptoms of multiple system atrophy were reported by a significantly larger group of patients' relatives than controls. These findings are possibly consistent with the hypothesis that multiple system atrophy develops as a result of a genetically determined selective vulnerability in the nervous system. Specific neuronal systems may become targets for environmental insults or toxins, and the disease state may occur when ageing neuronal systems can no longer sustain functional capacity. This preliminary study supports the need to further explore possible environmental, occupational, and familial contributions to the aetiology of multiple system atrophy.If you do not wish to belong to shydrager, you may unsubscribe by sending a blank email to shydrager-unsubscribe