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RESEARCH STUDY: Hytrin

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Pam:

Thanks for the info. someone posted s reference to this study earlier with

only a phone number. I have called Dr. S twice and spoken to his secretary

about getting this info made available. Dr. S was supposed to get back

tome; have not heard back as yet.

Your info does not indicate clearly which symptoms they feel might be

affected. Also, I suspect travel to Cleveland would be required.

Message: 10

Date: Fri, 30 Aug 2002 18:57:57 -0300

Subject: RESEARCH STUDY: Hytrin

Opportunity for Patients with Multiple System Atrophy

The Cleveland Clinic Foundation is beginning a study investigating the

effects of the drug Hytrin (Terazosin) on improving the symptoms commonly

associated with Multiple System Atrophy. Hytrin is a commonly used,

FDA-approved medication used in the treatment of Benign Prostatic

Hypertrophy (BPH) (to relieve urinary retention) and Hypertension (to lower

blood pressure). Patients interested in participating would undergo a

neurological and physical evaluation including questionnaires and timed

motor tests. Subjects are then randomized, like a flip of a coin, to either

Hytrin or a placebo for several weeks and undergo a series of neurological

and physical evaluations. Neither you nor your doctor will know if you are

on the study medication. Every one or two weeks for 12 weeks (end of

study), subjects will undergo further neurological evaluations.

For more information, contact Ruthie Kolb, at or Dr.

Thyagarajan Subramanian at .

Sennewald Charlottesville, Virginia

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FYI ... that info I posted came directly from Dr. Subramanian.

Take care,

Pam

RESEARCH STUDY: Hytrin

>

>

> Opportunity for Patients with Multiple System Atrophy

>

>

> The Cleveland Clinic Foundation is beginning a study investigating the

> effects of the drug Hytrin (Terazosin) on improving the symptoms commonly

> associated with Multiple System Atrophy. Hytrin is a commonly used,

> FDA-approved medication used in the treatment of Benign Prostatic

> Hypertrophy (BPH) (to relieve urinary retention) and Hypertension (to

lower

> blood pressure). Patients interested in participating would undergo a

> neurological and physical evaluation including questionnaires and timed

> motor tests. Subjects are then randomized, like a flip of a coin, to

either

> Hytrin or a placebo for several weeks and undergo a series of neurological

> and physical evaluations. Neither you nor your doctor will know if you

are

> on the study medication. Every one or two weeks for 12 weeks (end of

> study), subjects will undergo further neurological evaluations.

>

>

> For more information, contact Ruthie Kolb, at or Dr.

> Thyagarajan Subramanian at .

>

>

> Sennewald Charlottesville, Virginia

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