RESEARCH: Interleukin-1beta gene polymorphism in multiple system atrophy.

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Mov Disord 2002 Jul;17(4):808-811

Contribution of the interleukin-1beta gene polymorphism in multiple system

atrophy.

Nishimura M, Kawakami H, Komure O, Maruyama H, Morino H, Izumi Y, Nakamura

S, Kaji R, Kuno S.

Department of Clinical Neuroscience, Tokushima University Hospital,

Tokushima, Japan.

We studied genetic polymorphisms in the promoter region at position -511 of

the interleukin (IL) -1beta gene (IL-1B-511) and at position -889 of the

IL-1alpha gene (IL-1A-889), in 111 Japanese patients with multiple system

atrophy (MSA) and 160 controls. The distribution of IL-1B-511 was

significantly different between MSA patients and controls, because of the

under-representation of patients with homozygotes for allele 2

(IL-1B-511*2), a high producer of IL-1beta. The frequency of IL-1A-889*2, a

high secretor of IL-1alpha, was also decreased in MSA patients. Our findings

suggest that abnormal cytokine expression may be implicated in the

pathogenesis of MSA. Copyright 2002 Movement Disorder Society

PMID: 12210881 [PubMed - as supplied by publisher]