Research: Childhood Autism and Eosinophilic Colitis

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Abstract

Background/Aims: The significance of the association between many

gastrointestinal pathologies and autism is yet to be discovered. The aim of this

report is to highlight an association between autism and microscopic

eosinophilic colitis in 2 children. The possible mechanisms that may connect

these two conditions are discussed. Methods and Results: A rare association

between autism and microscopic eosinophilic colitis in 2 children is reported

through retrospective chart review. Common causes of secondary eosinophilic

colitis were excluded. Conclusion: This report suggests the possibility of

either impaired intestinal barrier function or an aberrant immune system that

predisposes autistic children to sensitization to environmental antigens. Large

controlled studies are needed to examine this hypothesis.

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