OT: McCandless response to transdermal LDN

[Guest guest]

Here is what Dr. Jacquelyn McCandless has to say:

Carol

wrote......

Dr. McCandless,

Your thoughts on LDN Capsules vs Transdermal from to Dr. JMcCandless:

Posted on http://www.ahsta.com/Community/ForumArch....ts/Default.aspx

" Dr. Zagon says that LDN cream keeps working in the system so that it ends

up being a high dose rather than a low dose because the receptor is

continuously blocked. This is not how LDN is supposed to be used for

autoimmunity, though it is used in this format as an eye ointment (e.g. corneal

scarring) and topically for wound healing in diabetics.

However, it is not recommended that one use trans dermal creams for the purpose

of inhibiting auto antibody production. A low dose pill is much better. "

My answer to , and cc'd to Dr. Ian Zagon, Dr. Jill and Dr. Skip

Lenz:

: Though I admire Dr. Zagon immensely, I am quite certain he is incorrect

about TD-LDN made per Coastal Compounding's formula with emu oil; the

transdermal goes into the blood stream immediately, sooner than the time it

takes for a tablet or capsule to dissolve and get into the blood stream. I have

not done tests checking its receptor blockage; if he has I would appreciate

receiving this information. However, I tell parents they can wash the cream off

after 15 or 20 minutes; it is already doing its job and does not continue to

send LDN after a very short time. His statement would only be true if the

carrier were a sustained release vehicle; emu oil takes it directly into the

blood stream (that's why it was chosen), and we have often seen children react

to the transdermal cream washed off or not within 30 minutes, showing increased

happiness and socialization. 80% of the children in my private clinical study

increased their CD4+ count in the 16 weeks of the study using Coastal's

transdermal cream, and many thousands of parents are happily giving this to

their children with autism. My e-list for autism and LDN (2002 members now) has

hundreds of reports after reports of the children clearly responding within

days and continuing to respond positively to the cream use of LDN.

I also have a group of Crohn's children responding marvelously to TD-LDN, some

of them going from 5 or more bloody stools a day to normal stools within 4-6

weeks of starting it.

I have just proposed a research project to be done at Northwestern University

with human brain slices showing that LDN increases the cysteine transporter

mechanism across the blood-brain-barrier to increase neuronal glutathione, and

it looks like we may be given research funding for this project by the Autism

Research Institute (pending availability).

I will cc Dr. Zagon and Dr. Jill to this post.

Jaquelyn McCandless MD