RE: Lactate to Pyruvate ratio - 88:1 What does this mean?

[Guest guest]

“The

normal lactate:pyruvate ratio usually is in the range of 10:1 to 20:1. Some

mitochondrial diseases such as pyruvate hydrogenase deficiency have normal

lactate:pyruvate ratios. On the other hand, elevated ratios suggest a defect in

oxidation phosphorylation. As a result, the hydrogen ion pressure increases in

the cell and forces the enzyme reaction in the direction of lactate, and the

lactate:pyruvate ratio consequently increases above 20:1.

The

cerebrospinal fluid (CSF) lactate level is more informative when the patient

has a condition that affects the central nervous system. A normal CSF lactate

militates against a mitochondrial disease, but it does not rule this diagnosis

out completely. A high pyruvate in the presence of a normal lactate has little or

no meaning. Pyruvate is more difficult to measure in the laboratory and it is

likely that the result reported represents a laboratory error.

The

need for a skeletal muscle biopsy should not be determined by the lactate and

pyruvate levels in the blood or the CSF. Examination of the biopsy tissue may

be more informative and would allow a more precise determination as to whether

your child has a mitochondrial disorder. “

-Darryl

C. De Vivo, M.D., MDA Clinic Director, Columbia Presbyterian Medical Center,

New York, NY

Suzanne M. man

Embroidery Journal

Inspiring Ideas for Home Embroiderers

& Professional Crafters

www.embroideryjournal.com

or fax

From: davidrich31843

Sent: Monday, October 11, 2004

7:06 AM

To: Mito

Subject: Lactate to Pyruvate ratio - 88:1 What

does this mean?

We are in the begining stage of determining the

type of Mito

Disorder that Connor has. We did some blood tests

which all came

back negative - which I believe is quite common.

Howver we did get a

result of the following RATIO... 88:1 Latate to

Pyruvate level, with

the pyruvate level being considered normal.

Any ideas on what in real terms this means...we

will be trying to do

a muscle biopsy soon...but they seem reluctant to

do them in South

Africa for one or other reason.

Regards

Please contact

mito-owner with any problems or questions.

[Guest guest]

Thanks for the reply...

I'm not sure if i'm reading you right but the results were a 88:1 with the lactate level higher than the pyruvate. This indicates a 4:1 level higher than your stated norm (at the higher level). I was told that this indiates a Mito disorder of some type, which together with the MRI results (basal ganglia problems and atrophy) and his other symtoms - inter alia hypotonia, nystagmus and hearing loss - seemed to confirm it.

RE: Lactate to Pyruvate ratio - 88:1 What does this mean?

“The normal lactate:pyruvate ratio usually is in the range of 10:1 to 20:1. Some mitochondrial diseases such as pyruvate hydrogenase deficiency have normal lactate:pyruvate ratios. On the other hand, elevated ratios suggest a defect in oxidation phosphorylation. As a result, the hydrogen ion pressure increases in the cell and forces the enzyme reaction in the direction of lactate, and the lactate:pyruvate ratio consequently increases above 20:1.

The cerebrospinal fluid (CSF) lactate level is more informative when the patient has a condition that affects the central nervous system. A normal CSF lactate militates against a mitochondrial disease, but it does not rule this diagnosis out completely. A high pyruvate in the presence of a normal lactate has little or no meaning. Pyruvate is more difficult to measure in the laboratory and it is likely that the result reported represents a laboratory error.

The need for a skeletal muscle biopsy should not be determined by the lactate and pyruvate levels in the blood or the CSF. Examination of the biopsy tissue may be more informative and would allow a more precise determination as to whether your child has a mitochondrial disorder. “

-Darryl C. De Vivo, M.D., MDA Clinic Director, Columbia Presbyterian Medical Center, New York, NY

Suzanne M. man

Embroidery Journal

Inspiring Ideas for Home Embroiderers & Professional Crafters

www.embroideryjournal.com

or fax

From: davidrich31843 Sent: Monday, October 11, 2004 7:06 AMTo: Mito Subject: Lactate to Pyruvate ratio - 88:1 What does this mean?

We are in the begining stage of determining the type of Mito Disorder that Connor has. We did some blood tests which all came back negative - which I believe is quite common. Howver we did get a result of the following RATIO... 88:1 Latate to Pyruvate level, with the pyruvate level being considered normal. Any ideas on what in real terms this means...we will be trying to do a muscle biopsy soon...but they seem reluctant to do them in South Africa for one or other reason.RegardsPlease contact mito-owner with any problems or questions. Please contact mito-owner with any problems or questions.

[Guest guest]

I just cut and pasted a quote from the

doctor mentioned. I remembered reading it recently, it came of the MDA web

site, so I can’t offer you further info, I just thought it may help you

dissect it further, Best Regards..

Suzanne

I'm not sure if i'm reading you right but the results were a

88:1 with the lactate level higher than the pyruvate. This indicates a 4:1

level higher than your stated norm (at the higher level). I was told that this

indiates a Mito disorder of some type, which together with the MRI results

(basal ganglia problems and atrophy) and his other symtoms - inter alia

hypotonia, nystagmus and hearing loss - seemed to confirm it.

Lactate to Pyruvate ratio - 88:1 What

does this mean?

We are in the begining stage of determining the

type of Mito

Disorder that Connor has. We did some blood tests

which all came

back negative - which I believe is quite common.

Howver we did get a

result of the following RATIO... 88:1 Latate to

Pyruvate level, with

the pyruvate level being considered normal.

Any ideas on what in real terms this means...we

will be trying to do

a muscle biopsy soon...but they seem reluctant to

do them in South

Africa for one or other reason.

Regards

Please

contact mito-owner with any problems or questions.

Please

contact mito-owner with any problems or questions.

Please

contact mito-owner with any problems or questions.

[Guest guest]

,

From our experience and research I was told that there was not a lab

capable of examining and interpretating muscle biopsies. We were

planning to bring Kayley to the USA for testing. I think that many

in this group will agree that Dr Schoffner in Atlanta in one of the

best mito diagnostician. Atlanta is the main entrance airport for

flights from Cape Town.

Take a look at this link from the UMDF it is a great article that

details the diagnostic route

http://www.ccjm.org/pdffiles/COHEN701.PDF

http://www.umdf.org/pdf/MITOCYTO.PDF

The L/P ratio that Connor has show a high level a lactate and it is

one of those markers that drs use, but high levels do indicate mito

or a defect in the process by which energy is made, oxidative

phosphorylation or respiratory chain complex.

Regards

> Thanks for the reply...

>

> I'm not sure if i'm reading you right but the results were a 88:1

with the lactate level higher than the pyruvate. This indicates a

4:1 level higher than your stated norm (at the higher level). I was

told that this indiates a Mito disorder of some type, which together

with the MRI results (basal ganglia problems and atrophy) and his

other symtoms - inter alia hypotonia, nystagmus and hearing loss -

seemed to confirm it.

> Lactate to Pyruvate ratio - 88:1 What does this

mean?

>

>

>

>

> We are in the begining stage of determining the type of Mito

> Disorder that Connor has. We did some blood tests which all came

> back negative - which I believe is quite common. Howver we did

get a

> result of the following RATIO... 88:1 Latate to Pyruvate level,

with

> the pyruvate level being considered normal.

>

> Any ideas on what in real terms this means...we will be trying

to do

> a muscle biopsy soon...but they seem reluctant to do them in

South

> Africa for one or other reason.

>

> Regards

>

>

>

>

>

>

> Please contact mito-owner with any problems or

questions.

>

>

>

>

>

>

>

> Please contact mito-owner with any problems or

questions.

>

>

>