Re: Gut/Autism Report for & all

[Guest guest]

Dear all,

I will try to get a real copy of this article and make an official

translation into Finnish. Could anyone send more trace than Journal

of Pediatrics, March 2001? Publicer, place of publication etc. Maybe

those who subscribe to FEAT magazine could find the source there?

This will make a lovely effect to our pediatric neurologist, social

insurance people etc. not to talk about other parents.

Thanks for help!

Kati

> Another FEAT article, as promised:

>

> Study Lends Support to Leaky Gut Theory of Autism

>

> " This is consistent with increasing evidence for gut

> epithelial dysfunction in autism " - Dr. Simon Murch

>

>

> A Distinct Lymphocytic Colitis With Epithelial Damage In Autistic

> Children Researchers have confirmed a distinct lymphocytic colitis

in

> autistic spectrum disorders in which the epithelium appears

> particularly affected, and have reported their findings in March's

> Journal of Pediatrics.

>

> A team from the Royal Free and University College School of Medicine

> and St Mark's Hospital, London, England investigated the

> characteristics of colitis with ileal lymphoid nodular hyperplasia

> (LNH) in children, and determined whether LNH was specific for

autism.

> Ileo-colonoscopy was performed in 21 consecutively evaluated

children

> with autistic spectrum disorders and bowel symptoms.

>

> Blinded comparison was made with 8 children with histologically

normal

> ileum and colon, 10 developmentally-normal children with ileal LNH,

> 15 with Crohn's disease, and 14 with ulcerative colitis.

> The researchers performed immunohistochemistry for cell lineage and

> functional markers, and histochemistry for glycosaminoglycans and

> basement membrane thickness.

>

> Histology demonstrated lymphocytic colitis in the autistic children,

> less severe than classical inflammatory bowel disease. However,

> basement membrane thickness and mucosal cell density were

> significantly increased above those of all other groups, including

> patients with inflammatory bowel disease. CD8+density and

> entraepithelial lymphocyte numbers were higher than

> those in the Crohn's disease, LNH, and normal control groups; and

CD3

> and plasma cell density and crypt proliferation were higher than

> those in normal and LNH control groups. Epithelial, but not lamina

> propria, glycosaminoglycans were disrupted. However, the

epithelium

> was HLA-DR-, suggesting a predominantly TH2 response.

>

> Dr Simon Murch said on behalf of the group, " Immunohistochemistry

> confirms a distinct lymphocytic colitis in autistic spectrum

> disorders, in which the epithelium appears particularly affected.

> This is consistent with increasing evidence for gut epithelial

> dysfunction in autism. "

>

> In an accompanying Editorial Perspective, F. Balistreri

> comments, " This seems to point to gut epithelial dysfunction

leading

> to altered permeability and subsequent entry of central nervous

> system-altering substances.

>

> " It follows that treatment of the gut disease may affect the CNS

> disease. "