NSAIDs contraindications

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Acetaminophen (Tylenol) has a label warning against long-term use. I've been

plagued by headaches all my life. Once long ago I was using tylenol a lot,

stupidly ignoring that warning, and I had a horrible reaction, where I was

really woozy and couldn't walk without falling down from dizziness. This

took several hours to subside, and I haven't touched the stuff since.

I don't recall whether it's on the label/insert or I read it elsewhere, but

long-term use can lead to irreversible liver damage. This is definitely a

red flag regarding mito. I have hepatic steatosis (fatty liver) and I

believe that is related to my MSL / MERRF. One has caused (or at least

exacerbated?) the other two, or perhaps all were caused by something else

underlying. My latest guess is that my genetic MERRF was exacerbated by

environmental triggers, but who knows?

Separate question: My current neuro (who knows full well about mito) has

prescribed for my headaches, 800 mg. ibuprofen (four standard pills) three

times a day. ASIDE from GI complications (which I don't have, but obviously

hope to avoid), does anyone know of mito contraindications for this rather

large ibuprofen dosage? It seemed to help somewhat for the first week or so,

but now I'm having new worse headache symptoms, so I'm not sure I'll be

staying with this regimen.

Steve D.

P.S. Friendly reminder: please have mercy on us email-digest members, and

occasionally snip off unnecessary trailers of replies to replies. By the

way, it also wouldn't hurt to change the " Subject: " when replies have gone

on to a new issue. Thanks in advance.

> Date: Tue, 5 Jul 2005 19:37:08 -0500

>

> Subject: RE: h pylori

>

> Acetaminophen induces caspases-dependent apoptosis with mitochondria as

> primary target.

>

> Pharmacol Toxicol. 2002 Jan;90(1):38-50

>

>

>

> Apoptosis is a form of cell death essential for tissue homeostasis and

> development. It is also used as a cellular response to stress or

pathogens.

> Deregulated apoptosis can contribute to many forms of human diseases such

as

> cancer, autoimmunity, heart disease, immunodeficiencies and

> neurodegenerative disorders.

>

>

>

> _____

>

> From: [mailto: ] On

Behalf

> Of Dolores

> Sent: Tuesday, July 05, 2005 7:10 PM

> To:

> Subject: Re: h pylori

>

>

>

> Yes, even my pain medication has a tylenol base, so it's heck if you do

and

> heck if you don't! Dr. Feagan told me that so many of the gastro problems

> are all related to Mito and it seems that all of my labs are coming back

> leaning toward a definite Mito diagnosis. So far I have my neurosurgeon,

my

> orthopaedic doctor, my neurologist, my hematologist/genetics doctor and

now

> Dr. Feagan my gastro all are very adamant that I do have Mito. Oh well,

> time will tell and if I could find a way to get to KU a lot of things

would

> be definite one way or the other and if it's NO then I have to start all

> over again! I'm not really looking forward to that process all over

again.

> Thanks, Dolores

>

> Laurie Fitzgerald laurie.fitzgerald@...> wrote:Dolores

>

> If you can't take anything other than Tylenol, try not to take it if

> you can get along without it. It is not recommended for those with

> mito. I can't remember exactly why - either it interfers with

> respiratory chain or can affect the liver.

>

> laurie

>

>

> > Pepto Bismol might indeed have aggravated your ulcer - it has

> > salicylates (close aspirin relatives, but which the company is quick

> > to say " non-aspirin salicylates " ) in it. It should be avoided by

> > anyone sensitive to aspirin or other NSAIDs, to the point they don't

> > recommend Pepto Bismol for kids under 12, due to a potential risk of

> > Reye's syndrome.

> >

> > Take care,

> > RH

> >

> >

> > > I wasn't sure what this H pylori

> > stuff was as it was a new one on

> > > > me, it's good to know that it isn't all that rare, all I need is

> > > > another rare disease? Thanks for the info, Dolores

> > >

> > > I was told by my GI doctor that up to 80% of all ulcers contain H.

> > > pylori. Then they got my biopsy results back and found out I

> > didn't

> > > have it. I've been on Prevacid Solutabs for a while. I've been on

> > > Prevacid off and on for about 10 years. My ulcers are due to

> > several

> > > months of using Naproxen and Entex LA for a bad back. My GI doctor

> > > said that even one aspirin can cause an ulcer.

> > >

> > > I basically try to heal what I've got, then if the acid reflux gets

> > > better, I decrease my dosage until I'm completely off it, which has

> > > happened for years at a time.

> > >

> > > YMMV, I'm not a medical doctor, I suppose this " messing around with

> > > dosage amounts " I learned from the mito cocktail has worn off on

> > > other things...

> > >

> > > Take care,

> > > RH