Caution regarding new Diabeties drug about to be approved by the FDA - NMR

[Guest guest]

I know this is directly mito related, but since many are diabetic, I

thought this was important information to pass on.

*/JAMA/-EXPRESS EARLY RELEASE

Effect of Muraglitazar on Death and Major Cardiovascular Events *

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Muraglitazar is a new drug developed to both lower blood glucose levels

and improve blood lipids in patients with type 2 diabetes. On September

9, 2005, a US Food and Drug Administration (FDA) advisory panel strongly

recommended approval of muraglitazar, and on October 18, 2005, the FDA

issued an " approvable letter " for the drug. However, in a review of data

from Phase 2 and 3 trials conducted by the drug manufacturer and

provided to the FDA, Nissen and colleagues found that muraglitazar was

associated with an excess incidence of the composite endpoint of death,

major adverse cardiovascular events, and congestive heart failure. FREE

ARTICLE

MORE > http://jama.ama-assn.org/misc/294.20.joc50147.pdf>

http://jama.ama-assn.org/