Guest guest Posted November 30, 2005 Report Share Posted November 30, 2005 Vivian I have copied a summary of medication info. below. laurie MEDICATIONS CONTRAINDICATED IN MITOCHONDRIAL DIESASE On page 269 of the Syllabus for the International Conference on Mito Disease, 1997 you will find the following recommendations: " Treatment remains largely symptomatic and does not significantly alter the course of the disease. It includes avoidance of drugs and procedures known to have a detrimental effect, symptomatic treatments, supplementation with co-factors, prevention of oxygen radical damage to mitochondrial membranes and dietary recommendations. " " It is advisable to avoid Sodium Valproate and barbiturates which inhibit the respiratory chain and have occasionally been shown to precipitate hepatic failure in respiratory enzyme deficient children. Tetracyclines and chloramphenical should be avoided as well, as they inhibit protein synthesis. " As well certain types of anaesthesia are also contraindicated. There is a wonderful and comprehensive article dealing with the safety of anaesthesia in mitochondrial cytopathy patients in the October 98 issue of the United Mitochondrial Disease Federation newsletter, as well as at the UMDF site. It is not always possible to avoid these drugs but at least if you are informed ahead of time and the possibility of an alternative exists, you can make an informed decision. There is no doubt that some folks with mitochondrial cytopathy have used these drugs uneventfully, although the potential is still there. Be an informed consumer! Cohen and Shoffner lists about anaesthetic agents. Barbiturates - Inhibits complex I activity at high levels Benzodiazepines - Inhibits adenosine nucleotide translocase Propofol and/or lipid carrier - Inhibits mitochondrial function Halothane - Increased risk for heart rhythm disturbance Nitrous Oxide - Neurotoxic, possibly by increasing nitric oxide production, which inhibits cisacotinase and iron-containing electron transport enzymes: affecting energy production Non-depolarizing Agents - Increased sensitivity to the paralytic effects and prolonged responses reported Local Anaesthetics - Bupivacaine uncouples oxidation and phosphorylation Should never use Lactated Ringer's solution (Ringer's Lactate) because it contains lactic acid. Depolarizing agents (Succinylcholine) bothers some people. **************************** Valproate or Depakote (Valproic Acid) is an anti-convulsant. It is known to be a potential toxin to those with either mitochondrial disorders or metabolic disease. It can cause severe hepatoxicity or liver failure in susceptible persons. Phenobarbital is another potential mitochondrial toxin that can also be dangerous to those with mitochondrial cytopathy. It is wise to always ask your pharmacist for the generic name of any drug being prescribed for someone with mitochondrial cytopathy. Hormonal Birth Control Aminoglycosides are ototoxic for *some forms of Mitochondrial Cytopathies - a specific genetic variation ( Mitochondrial 12S and 16S ribosomal RNA - mutation of A to G in the 12S rRNA at position 1555)* {Hutchins, Cortopassi 1994}. Aminoglycosides are *some* of the antibiotics which end in " _______mycin " . Ototoxic means that these drugs can cause hearing loss or deafness. ASK YOUR PHARMACIST AND PRESCRIBING DOCTOR. Ergotamines due to the impact on hepatic function. Neuroleptic drugs such as Haloperidol, Chlorpromazine, and Thiothixene. Lipitor should not be used by someone with Mitochondrial disease as it depletes CoQ10 from the cells. Steroids can be used but should be used only when absolutely necessary and this should be a very low dosage and not for an extended period of time. Friendly alternatives (?) Lamictal seems to be being used successfully. Topomax also appears to be mitochondrial-friendly for intractable seizures. > Is there a list anywhere that will tell me which antibiotics are > easier on a mito patient? > > My son Jack has been sick for three weeks and the doc thinks there > maybe a secondary infection, but I don't want to use antibiotics > because the Z-pack and tetracycline group cause great havoc on his > stomach and make it shut down...(pain and inability to pass stool and > we get into this long drawn out trying to get him better. > > Thanks. > > vivian > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 1, 2005 Report Share Posted December 1, 2005 thanks laurie for taking the time to get this to me... Vivian > > Is there a list anywhere that will tell me which antibiotics are > > easier on a mito patient? > > > > My son Jack has been sick for three weeks and the doc thinks there > > maybe a secondary infection, but I don't want to use antibiotics > > because the Z-pack and tetracycline group cause great havoc on his > > stomach and make it shut down...(pain and inability to pass stool and > > we get into this long drawn out trying to get him better. > > > > Thanks. > > > > vivian > > > Quote Link to comment Share on other sites More sharing options...
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