hypothyroidism not linked?

February 6, 2006

Pamela

Thyroid problems are definitely related to mito in many cases - just

not mine. My body developed antibodies to the thyroid gland and

gradually it was destroyed by a combination of the antibodies and the

thyroid meds (the goal of meds was to shrink the gland and take over

the function).

laurie

> Laurie just wondering why hypothyroidism (which I've had since 13) given

> the label autoimmune is not linked to mito? I also was told that also by

> my mito doc - seems to me something cellular based like mito could cause any

> thing.. pamela

>

> Re: Hello

>

> Hypothyroidism can be a part of mito. I have it, but mine happens to

> be autoimmune and not due to mito.

>

February 7, 2006

i was just wondering though why our bodies developed the antibodies in the first

place, and has a mito connection for this definitely been ruled out by

researchers... thank you for your answer Laurie (always searching, searching,

and really knowing that all the answers to the secrets of life won't ever be

found...)

Re: Hello

>

> Hypothyroidism can be a part of mito. I have it, but mine happens to

> be autoimmune and not due to mito.

>

February 7, 2006

Pamela

I was told by my mito docs (3) that it wasn't connected, but there has

been no research to my knowledge. Do you have Hashimotos Throiditis?

laurie

> i was just wondering though why our bodies developed the antibodies in the

> first place, and has a mito connection for this definitely been ruled out by

> researchers... thank you for your answer Laurie (always searching,

> searching, and really knowing that all the answers to the secrets of life

> won't ever be found...)

> Re: Hello

> >

> > Hypothyroidism can be a part of mito. I have it, but mine happens to

> > be autoimmune and not due to mito.

> >

February 7, 2006

Perhaps Pamela's thought is like mine - for me I think my mito

disease may be caused by antibodies to Complex I or some such.

Autoimmune diseases in general are linked, that is they all represent

the body not " weeding out " antibodies that attack one's own body. So

if this " self-recognition " is messed up, perhaps it is possible that

more than one type of " auto " antibody is slipping through.

The way antibodies work is that there are many, many, many different

kinds of antibodies floating around in our bodies - the body has to

filter out the ones that might attack the body, and antibodies

that " find the target " of an antigen put their cells in gear to clone

and get rid of the antigens.

But if some antibodies miss the " self " filter, an autoimmune disease

can occur. So if it happened " once " for the thyroid antibodies,

perhaps it is also happening for some part of the mitochondrial

system. I have high anticardiolipin antibodies, and my mito symptoms

disappeared during my pregnancies, so I feel strongly about an

autoimmune element.

On a side note, I find it odd that doctors like to say " there's no

way they are related " so often - like they are experts in the

interrealtionship of diseases (which isn't really studied, especially

not across systems and more especially not for mito)!

Take care,

RH

> > Laurie just wondering why hypothyroidism (which I've had since

13) given

> > the label autoimmune is not linked to mito? I also was told

that also by

> > my mito doc - seems to me something cellular based like mito

could cause any

> > thing.. pamela

> >

> > Re: Hello

> >

> > Hypothyroidism can be a part of mito. I have it, but mine

happens to

> > be autoimmune and not due to mito.

> >

February 7, 2006

RH

My cardiolipin is normal.

laurie

> Perhaps Pamela's thought is like mine - for me I think my mito

> disease may be caused by antibodies to Complex I or some such.

> Autoimmune diseases in general are linked, that is they all represent

> the body not " weeding out " antibodies that attack one's own body. So

> if this " self-recognition " is messed up, perhaps it is possible that

> more than one type of " auto " antibody is slipping through.

>

> The way antibodies work is that there are many, many, many different

> kinds of antibodies floating around in our bodies - the body has to

> filter out the ones that might attack the body, and antibodies

> that " find the target " of an antigen put their cells in gear to clone

> and get rid of the antigens.

>

> But if some antibodies miss the " self " filter, an autoimmune disease

> can occur. So if it happened " once " for the thyroid antibodies,

> perhaps it is also happening for some part of the mitochondrial

> system. I have high anticardiolipin antibodies, and my mito symptoms

> disappeared during my pregnancies, so I feel strongly about an

> autoimmune element.

>

> On a side note, I find it odd that doctors like to say " there's no

> way they are related " so often - like they are experts in the

> interrealtionship of diseases (which isn't really studied, especially

> not across systems and more especially not for mito)!

>

> Take care,

> RH

>

> > > Laurie just wondering why hypothyroidism (which I've had since

> 13) given

> > > the label autoimmune is not linked to mito? I also was told

> that also by

> > > my mito doc - seems to me something cellular based like mito

> could cause any

> > > thing.. pamela

> > >

> > > Re: Hello

> > >

> > > Hypothyroidism can be a part of mito. I have it, but mine

> happens to

> > > be autoimmune and not due to mito.

> > >

February 10, 2006

I am sorry but not been able to keep up with the list lately but try to

scan the digest.

I have been very interested in the thyroid and mito. and have been over

on the about com site where I told a few people that I had mito.

diagnosed on biopsy, this caused many months of research as some posters

were really interested in the subject. The result was, if I can find it

,Complex ! is affected in Autoimmne Thyroid as is Cytochrome C ,

somewhere in the depths of this computer are the pubmed links we all

found . whether the hashis causes the deficiency or the other way

round I cannot say but it is a most interesting subject, Pubmed with a

search of 'thyroid mitochondria complex' starts a good trail to follow.

Also i have been reading as much as possible here in the UK how the

private Doctors treat thyroid, and found that what is called the 'Mito

Cocktail' is routinely prescribed to thyroid patients here.

I have been in hospital for re-assessment, still labelled on the

discharge summary as 'Mitochondrial Cytopathy working diagnosis' but

with many autoimmune diseases., there is now a query over

?Crohns/Colitis as part of my mito. The abdominal pain in my case which

they all just said mito. has now been caused, they think, by the massive

parietal antibody activity which has caused mucosal damage (I think I

have got that right) to my stomach and bowel, leading to loss of acid

and malabsorbtion and a swelling has shown on my left adrenal on CT

scan..

Still negative on EMG for Neuropathy and myopathy but got small fibre

neuropathy, don't understand that yet hope the Dr explains soon.

My Blood Pressure trouble I am now taking Bumetanide (loop diuretic)

with SandoK (potassium supplement) and Losarten Potassium, so hopefully

this time my body will stay in balance

Sorry this post is so long but have been having a feeling sorry for

myself phase..

Gillian

February 10, 2006

Gillian

I'm sorry you have not been doing well. I'm sending you a big cyber

hug. I hope you start getting some information from the docs soon.

laurie

>

> I am sorry but not been able to keep up with the list lately but try to

> scan the digest.

>

> I have been very interested in the thyroid and mito. and have been over

> on the about com site where I told a few people that I had mito.

> diagnosed on biopsy, this caused many months of research as some posters

> were really interested in the subject. The result was, if I can find it

> ,Complex ! is affected in Autoimmne Thyroid as is Cytochrome C ,

> somewhere in the depths of this computer are the pubmed links we all

> found . whether the hashis causes the deficiency or the other way

> round I cannot say but it is a most interesting subject, Pubmed with a

> search of 'thyroid mitochondria complex' starts a good trail to follow.

> Also i have been reading as much as possible here in the UK how the

> private Doctors treat thyroid, and found that what is called the 'Mito

> Cocktail' is routinely prescribed to thyroid patients here.

>

> I have been in hospital for re-assessment, still labelled on the

> discharge summary as 'Mitochondrial Cytopathy working diagnosis' but

> with many autoimmune diseases., there is now a query over

> ?Crohns/Colitis as part of my mito. The abdominal pain in my case which

> they all just said mito. has now been caused, they think, by the massive

> parietal antibody activity which has caused mucosal damage (I think I

> have got that right) to my stomach and bowel, leading to loss of acid

> and malabsorbtion and a swelling has shown on my left adrenal on CT

> scan..

>

> Still negative on EMG for Neuropathy and myopathy but got small fibre

> neuropathy, don't understand that yet hope the Dr explains soon.

> My Blood Pressure trouble I am now taking Bumetanide (loop diuretic)

> with SandoK (potassium supplement) and Losarten Potassium, so hopefully

> this time my body will stay in balance

>

> Sorry this post is so long but have been having a feeling sorry for

> myself phase..

>

> Gillian

>

February 10, 2006

don't say sorry Gillian - its really interesting. bit by bit we can grasp the

scope of mitochondrial dysfunction in our bodies - for instance from looking up

your word parietal i realize the gi problems are now down at the cellular level

and it all seems to make sense . pamela (non scientist)