Re: muscle biopsy results --need help

[Guest guest]

My interpretation and I'm not a doc, is that it neither confirms nor

rules out mito. It does seem to rule out some of the other metabolic

discorders involving things like glucose metabolism.

I had to have a fresh biopsy with specific complex testing to get a diagnosis.

Please let us know what Dr. Korson has to say about the result - he is

the doctor.

laurie

> Apologies for the long post but I need help. I got the pathology report

> back

> on my muscle biopsy from the surgeon. Will not see Hirano until May 19th.

>

> Husband thinks it says nothing. I need your opinions. Only clinical info

> given to pathologist was exercise intolerance.

>

> Sample was taken from left quadriceps

>

> Stains: Paraffin sections: Hematoxylin & eosin, Masson tirchrome,

> thioflavin

> S.

>

> Cryocetions: H&E, Gomori trichrome, NADH-TR, SHD, ATPase, acid phosphatase,

> phosphorylase, p[hosphofrictokinase, myoadenylate deaminase, cytochrome c

> oxidase.

>

> Tissue quality: Fair

>

> Fiber size: Variations in fiber size is increased due to a number of

> atrophic fivers of varying degrees. This is no grouped atrophy.

>

> Fiber type: Many, if not most, atrophic fibers are type 2 myofibers. No

> clear fiber type grouping is observed.

>

> Nuclei: No significant increase is observed in the number of myofibers

> with

> internally located nuclei.

>

> Fibers: Target/targetoid structures: Not evident.

> Necrotic sarcoplasm: None.

> Regeneration: None.

> Rimmed vacuoles: None.

> Other: An SDH stain shows no characteristic ragged red fiber or SSV

> (strongly reactive vessels). A cytochrome c oxidase shows rare fibers

> (roughly

> 0.5%) devoid of enzymatic activity. Some fibers exhibit increased

> interfibrillar

> network staining. It may indicate a mild proliferation of mitochondria in

> those fibers but its clinical significance is uncertain. An acid

> phosphatase

> stain shows no abnormally aggregated enzymatic reactivity in each myofiber.

>

> Phosphofructokinase, phosphorylase, and myoadenylate deaminase are normally

> detected in the muscle.

>

> Other: a thioflavidn S is negative with amyloid.

>

> Diagnosis: Skeletal muscle with non-specific alterations.

>

> Does this mean mito or not? Needle biopsy taken lower in my thigh had red

> ragged fibers.

>

>

>

[Guest guest]

> > Husband thinks it says nothing. I need your

> opinions. Only clinical info

> > given to pathologist was exercise intolerance.

I don't think that this really says a lot. But...why

wasn't the pathologist told what was suspected? To get

a report that means anything at all you need to have

an idea of what you're looking for so you do the

staining right. Who knows what is there and what it

means. Mito proliferation can happen when mitochondria

are not functioning properly.

Mom to the two best kids in the world!

http://www.caringbridge.org/visit/thomasandkatie

__________________________________________________