Guest guest Posted April 24, 2006 Report Share Posted April 24, 2006 Apologies for the long post but I need help. I got the pathology report back on my muscle biopsy from the surgeon. Will not see Hirano until May 19th. Husband thinks it says nothing. I need your opinions. Only clinical info given to pathologist was exercise intolerance. Sample was taken from left quadriceps Stains: Paraffin sections: Hematoxylin & eosin, Masson tirchrome, thioflavin S. Cryocetions: H&E, Gomori trichrome, NADH-TR, SHD, ATPase, acid phosphatase, phosphorylase, p[hosphofrictokinase, myoadenylate deaminase, cytochrome c oxidase. Tissue quality: Fair Fiber size: Variations in fiber size is increased due to a number of atrophic fivers of varying degrees. This is no grouped atrophy. Fiber type: Many, if not most, atrophic fibers are type 2 myofibers. No clear fiber type grouping is observed. Nuclei: No significant increase is observed in the number of myofibers with internally located nuclei. Fibers: Target/targetoid structures: Not evident. Necrotic sarcoplasm: None. Regeneration: None. Rimmed vacuoles: None. Other: An SDH stain shows no characteristic ragged red fiber or SSV (strongly reactive vessels). A cytochrome c oxidase shows rare fibers (roughly 0.5%) devoid of enzymatic activity. Some fibers exhibit increased interfibrillar network staining. It may indicate a mild proliferation of mitochondria in those fibers but its clinical significance is uncertain. An acid phosphatase stain shows no abnormally aggregated enzymatic reactivity in each myofiber. Phosphofructokinase, phosphorylase, and myoadenylate deaminase are normally detected in the muscle. Other: a thioflavidn S is negative with amyloid. Diagnosis: Skeletal muscle with non-specific alterations. Does this mean mito or not? Needle biopsy taken lower in my thigh had red ragged fibers. Quote Link to comment Share on other sites More sharing options...
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