Re: [...] other things being associated with Mito

May 29, 2006

Laurie

Right, I know that about mtDNA.. In fact, I know what I meant to say, it just

came out a bit garbled. :-) I was mainly trying to convey that finding MERRF in

blood proves inheritance (yes?), and I should have left out the part about

maternal inheritance. Too much information in one sentence, some of it downright

wrong, or at least misleading.

BTW I understand that there are some mutations seen in mtDNA that seem to have

arisen or been conveyed somehow from nDNA, in which case clearly the inheritance

path can be more complicated than just " maternal " . But I don't know how much is

known about this, esp. in regards to MERRF, so I suppose I should not venture

into that.

And yes, I've heard that about lipomas. Stands to reason, since they are somehow

related to fatty acid storage. The difficult part for me is that plain old

lipomas, even many or big ones, are almost invariably quite benign, though

unsightly and scary to patients. Thus, doctors learn to be rather dismissive of

them, and hence never bother learning about the differential diagnosis of the

very serious (but admittedly very rare) MSL.

While I'm un-garbling, when I said " MSL may be due to an inherited mito defect

triggered by some environmental exposure " I did NOT mean that the inherited mito

defect was triggered by the exposure. To be clearer: MSL may require BOTH the

inherited mito defect AND the environmental trigger.

Steve

Re: Questions about tongue atrophy and other things

> being associated with Mito

>

> Only if it is maternally transmitted. There are other forms of

> transmission also or it could be from an environmental toxin and not run

> in a family at all.

>

> >Oh, one last question for now: if you have Mito, doesn't that mean your

> mother and others in her family line also must have had it in some form?

> >

> >Thanks much,

> >

> >Randall

>

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