Re: mito caused by substances?

[Guest guest]

Steve,

I read an article by Bruce Cohen which mentions that mito can be

caused by environmental toxins (I think) including prescription

drugs (I'm sure he said that). However, it wasn't the main subject

of the article and he didn't go into any detail about it. I, too,

have been wondering if anyone in the group has " acquired " rather

than inherited mito and if there is any difference in the disease

itself. Anyway, if you're interested in the article, it's at:

www.ccjm.org/pdffiles/COHEN701.PDF. If the link doesn't work for

any reason, google " Mitochondrial Cytophies in Adults: What We Know

So Far " .

Best,

Shayna

>

> RH, and others...

>

> I am interested in your remark, excerpted below, about a drug that

causes

> mito damage.

>

> 1) Is there perhaps a distinction I'm missing, e.g. between mito

DAMAGE, and

> the mito DISEASE/DISORDER we have, on this list? Do you mean that

> erythromycin COULD be the SOLE cause of mito? Not so much in

yourself, but

> in ANYONE?

>

> 2) I'm not sure but I THINK this is the first I've heard (on THIS

list,

> anyway) about a SUBSTANCE causing mito. Seems we either have a

known genetic

> connection (or it's obvious, by inflicting multiple family

members), or are

> generally searching for same. Could you please list any other

substances

> known or thought to be in this category? I know of AARTs (such as

AZT, for

> HIV/AIDS), some environmental toxins such as mercury and certain

pesticides,

> and perhaps others (I suspected Depakote/valproate, in my case,

until MERRF

> was found in my blood, but I still wonder if it somehow

contributed). I'm

> very intrigued.

>

> 3) Do you have pointer(s) for more info?

>

> Steve D.

>

> > Date: Tue, 01 Nov 2005 18:27:52 -0000

> > From: " ohgminion "

> > Subject: Re: New to the group....again---MRI SPECTROSKY...

RESULTS ARE IN

> >

> > [...]

> > I was also called a hypochondriac by my brothers, I was sick for

six

> > or more weeks per year from 12 to 18. That's when I took A LOT

of

> > erythromycin, which now we know is one drug that can cause mito

> > damage.

> >

> > [...]

> >

> > Take care,

> > RH

>

[Guest guest]

That is kind, Laurie. Certainly I will appreciate it, whenever you are

able to to it. Thanks!!

Sunny

> Sunny

>

> I am a fellow MAC user. I will find the information tomorrow and post

> it. Today has been a busy day and I need to sit back and relax this

> evening.

>

> laurie

>

> O

[Guest guest]

Are there special resources available in St. Louis? The reason I ask is I'm

going there for Christmas.

Darlene

[Guest guest]

Yes, my mito was caused by exposure to pesticides. I do believe I had

the potential through heredity, but it would've lain dormant had it

not been for the pesticde exposure. In turn, this also caused chronic

fatigue syndrome and fibromyalgia. The onset of all 3 of these

disorders came within a couple weeks of the exposure. Before that I

was completely symptom free.

[Guest guest]

Very interesting, . Can you give any details of the pesticides?

I have elevated DDE ? in my blood, and was told that is the substance

that DDT is converted to by the body. Have never been able to find

follow up that makes sense, but... there are so many many issues to try

to follow up!

Regards

Sunny

> Yes,  my mito was caused by exposure to pesticides. I do believe I had

> the potential through heredity, but it would've lain dormant had it

> not been for the pesticde exposure. In turn, this also caused chronic

> fatigue syndrome and fibromyalgia. The onset of all 3 of these

> disorders came within a couple weeks of the exposure. Before that I

> was completely symptom free.

>

>

>

>

>

>

>

> Medical advice, information, opinions, data and statements contained

> herein are not necessarily those of the list moderators. The author of

> this e mail is entirely responsible for its content. List members are

> reminded of their responsibility to evaluate the content of the

> postings and consult with their physicians regarding changes in their

> own treatment.

>

> Personal attacks are not permitted on the list and anyone who sends

> one is automatically moderated or removed depending on the severity of

> the attack.

>

>

>

>

>

[Guest guest]

Pesticides are notorious for damage to the neuromuscular systems in

general, and have been implicated as the cause of other neuromuscular

diseases. A toxicologist would be the person to see about this

issue. Pesticides tend to accumulate in fatty tissues, so it is

difficult for the body to clear them.

Take care,

RH

>

> > Yes,  my mito was caused by exposure to pesticides. I do believe

I had

> > the potential through heredity, but it would've lain dormant had

it

> > not been for the pesticde exposure. In turn, this also caused

chronic

> > fatigue syndrome and fibromyalgia. The onset of all 3 of these

> > disorders came within a couple weeks of the exposure. Before

that I

> > was completely symptom free.

> >

> >

> >

> >

> >

> >

> >

> > Medical advice, information, opinions, data and statements

contained

> > herein are not necessarily those of the list moderators. The

author of

> > this e mail is entirely responsible for its content. List members

are

> > reminded of their responsibility to evaluate the content of the

> > postings and consult with their physicians regarding changes in

their

> > own treatment.

> >

> > Personal attacks are not permitted on the list and anyone who

sends

> > one is automatically moderated or removed depending on the

severity of

> > the attack.

> >

> >

> >

> >

> >

[Guest guest]

Absolutely. I have two first cousins, a brother and sister, with early-onset

Parkinson's. They had both been exposed (on the job) to certain noxious

chemicals known to be associated with Parkinson's. Very sad.

Barbara

> Pesticides are notorious for damage to the neuromuscular systems in

> general, and have been implicated as the cause of other neuromuscular

> diseases. A toxicologist would be the person to see about this

> issue. Pesticides tend to accumulate in fatty tissues, so it is

> difficult for the body to clear them.

>

> Take care,

[Guest guest]

Sunny,

I've always been particular about staying away from pesticides, but

now I am fanatical about it. I was exposed to a patient with scabies

(I am a nurse). I had a couple spots on my hand, which in hindsight

were probably nothing more than allergic dermatitis which I

frequently get. Since I work with newborns, the hospital was

cautious and sent me home and gave me permethrin (a pesticide) which

I had to apply to my skin over my entire body and leave it on for 8

hrs. I also did all the usual recommendations of laundering

everything including all the kid's bedding in hot water. Needless to

say, I spent all day in the basement doing wash with this permethrin

cream on me. It was September, and due to a weather change, my

basement became swarmed with flying ants (That's a whole other

story....if anybody needs to get rid of citronella ants email

me...they recur yearly) Being alarmed by the number of ants, I

reluctantly sprayed them with some raid. Main ingredient: yep, also

permethrin. So I was double whammied that day. The little window I

opened on the other side of the basement to air it was totally

inadequate. Within days I was ill with very bizzare symptoms. I had

also used DEET spray when camping that summer which I was trying very

hard to avoid, but the mosquitoes were horrendous! I currently have

a no pesticide policy. If you ever need any natural insect repellant

ideas. Let me know!