B12 q - Daughter depression (new)

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Joanne do you know if the B12 is effective (for anything) if a pathology test

says your B12 levels are normal? A couple of doctors have told me there is no

use taking it otherwise, while another said you need more.... thks pamela

Re: Daughter pelvic pain (gone) depression (new)

There are a number (albeit small) of individuals with mitochondrial disease or

other metabolic disease with severe depression or other spych issues, that seem

to respond very well to extremely high doses of vitatmin B12 taken sublingually.

IT isn't overly expensive so it might be worth trying. It doesn't taste great

but the clinical response has been remarkable.

pamelama33 pamelama33@...> wrote: Hi everyone - asking for your

thoughts again for my daughter (22).

First an update if you remember her last problem was acute pelvic pain which

was thought to be gynaecological as it seemed to come before and into her

period. Laparoscopy showed nothing significant. BC pill was tried continuously

and it made it much worse so after several dashes to emergency was finally

ceased. The pain was helped only by heat. It was unrelenting and I think broke

her down as she started blacking out (dx for this was neurocardiogenic vasovagal

syncope which some of you had mentioned already). Anyway we started her on

Magnesium Orotate 800 mg per day 2-3 months ago and amazingly the pain seems to

have gone away! Quite a miracle, so it must have been some sort of cramping or

spasm. As part of her mito investigations she has been to a gastroenterologist

who is checking her for dysmotility and he thinks that it might be related ie

spasm of the colon triggered by hormonal changes. Well hopefully it is gone and

she is not willing to stop the Mg

Orotate to find out !

With one problem gone another has started and that is severe and frightening

depression which is so unlike how she has been in the past. I believe she is in

crisis the only thing I am not sure about is whether it is just a direct result

of feeling low about not being able to perform over the last few years (she is

constantly fatigued and sick, glands up etc) and this affected school years and

further study in photography . Or perhaps there is a biochemical reason ie an

energy crisis between the mitochondria and the brain (perhaps related to all the

pain she has been experiencing over the last year) . I feel the latter must be

closer or maybe its a combination. Penny has been on CoQ10 300 mg for a few

months now and just started B2 - yet to try Carnitine but that is next. Any

other ideas and has anyone had anything similar? She is not really responding

that well to SSRI antidepressants at least yet (after a few weeks on them) they

are not enough to stop some

dramatic episodes of sudden diving into sobbing, shaking, episodes where she

is terrified she might hurt herself, temporary inability to function etc. Other

times she is quite happy and normal. I feel it has to be related to the mito. My

thinking is that no matter what you throw at someone they're not going to work

if the energy pathways are not there - does that make sense? I'm not sure

whether she needs more rest or more exercise - for sure we always strive for

better nutrition. Any ideas or experiences would be appreciated. Would be good

to understand the processes like some of you biochemistry wizards .. Pamela

(Melas) about Penny (also Melas)