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Protection against Fatal Pseudomonas aeruginosa Pneumonia in Mice after

Nasal Immunization with a Live, Attenuated aroA Deletion Mutant --

Infection and Immunity

http://www.pulmonologylinx.com/thearts.cfm?artid=519685 & specid=14

Conclusion: These data suggest that a combination of humoral and

cellular immunity is required for protection against P. aeruginosa lung

infections, that such immunity can be elicited by using aroA deletion

mutants, and that a multivalent P. aeruginosa vaccine composed of aroA

deletion mutants of multiple serogroups holds significant promise...

Becki

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