Fwd: MSA: Progression, Hypoxia Response

[Guest guest]

--- E-MOVE wrote:

>

> To: E-MOVE

> Date: Tue, 08 Oct 2002 23:30:07 GMT

> Subject: MSA: Progression, Hypoxia Response

>

> 1. Progression and prognosis in multiple system

> atrophy: An analysis of 230 Japanese patients

> H Watanabe, Y Saito, S Terao, T Ando, T Kachi, E

> Mukai, I Aiba, Y Abe, A Tamakoshi, M Doyu, M

> Hirayam, G Sobue

> Brain 2002;125:1070-1083

>

> The interval from symptom onset to combined motor

> and autonomic dysfunction is predictive of

> functional deterioration and survival in MSA,

> according to this study.

>

> Consensus criteria were used to identify 230

> patients with MSA, of whom 131 were male. Mean age

> of onset was 55.4 years. Cerebellar symptoms (MSA-C)

> predominated in 155 patients, while parkinsonian

> symptoms (MSA-P) were most prominent in 75. The

> median time from symptom onset to multi-system

> involvement was 2 years. Median survival time was

> 9.0 years (range 2-17 years). Time to assisted

> walking, wheelchair requirement, bed confinement,

> and death were proportional to time between symptom

> onset and multisystem involvement. Patients in whom

> multisystem involvement occurred within one year of

> symptom onset proceeded to each of these milestones

> 2-3 times as fast as those for whom multisystem

> involvement occurred after 3 years or more.

>

>

> 2. Impaired chemosensitivity to hypoxia is a marker

> of multiple system atrophy

> T Suda, H Onodera, S Okabe, Y Kikuchi, Y Itoyama

> Ann Neurol 2002;52:367-371

>

> Impaired ventilatory response to hypoxia can help

> predict whether patients with idiopathic late-onset

> cerebellar ataxia will progress to MSA-C, according

> to this study.

>

> Hypoxia ventilatory response (change in respiratory

> rate versus change in blood O2) was measured in 9

> controls, 6 patients with MSA, 13 with ILOCA, 31

> with Parkinson's disease, and 7 with SCA-3. HVR was

> 0.51 in controls, 0.09 in MSA patients, 0.47 in

> ILOCA patients (range 0-1.4), 0.16 in PD patients,

> and 0.59 in SCA-3 patients. Of 7 ILOCA patients

> whose HVR values were less than 0.3, 6 progressed to

> MSA-C within 3 years. No ILOCA patients with values

> above this did.

>

> Copyright 2002 WE MOVE

> Editor: (rrobinson@...)

> -

> Your E-MOVE news subscription is provided free of

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> TEL 800-437-MOV2

> or 212- 875-8312. Thank you so much!

> -

> This document may be freely redistributed by email

> only in its

> unedited form. We encourage you to share it with

> your colleagues.

> Visit http://www.wemove.org/emove for E-MOVE

> archives and information

> on subscribing to E-MOVE. To unsubscribe, visit

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[Guest guest]

--- E-MOVE wrote:

>

> To: E-MOVE

> Date: Tue, 08 Oct 2002 23:30:07 GMT

> Subject: MSA: Progression, Hypoxia Response

>

> 1. Progression and prognosis in multiple system

> atrophy: An analysis of 230 Japanese patients

> H Watanabe, Y Saito, S Terao, T Ando, T Kachi, E

> Mukai, I Aiba, Y Abe, A Tamakoshi, M Doyu, M

> Hirayam, G Sobue

> Brain 2002;125:1070-1083

>

> The interval from symptom onset to combined motor

> and autonomic dysfunction is predictive of

> functional deterioration and survival in MSA,

> according to this study.

>

> Consensus criteria were used to identify 230

> patients with MSA, of whom 131 were male. Mean age

> of onset was 55.4 years. Cerebellar symptoms (MSA-C)

> predominated in 155 patients, while parkinsonian

> symptoms (MSA-P) were most prominent in 75. The

> median time from symptom onset to multi-system

> involvement was 2 years. Median survival time was

> 9.0 years (range 2-17 years). Time to assisted

> walking, wheelchair requirement, bed confinement,

> and death were proportional to time between symptom

> onset and multisystem involvement. Patients in whom

> multisystem involvement occurred within one year of

> symptom onset proceeded to each of these milestones

> 2-3 times as fast as those for whom multisystem

> involvement occurred after 3 years or more.

>

>

> 2. Impaired chemosensitivity to hypoxia is a marker

> of multiple system atrophy

> T Suda, H Onodera, S Okabe, Y Kikuchi, Y Itoyama

> Ann Neurol 2002;52:367-371

>

> Impaired ventilatory response to hypoxia can help

> predict whether patients with idiopathic late-onset

> cerebellar ataxia will progress to MSA-C, according

> to this study.

>

> Hypoxia ventilatory response (change in respiratory

> rate versus change in blood O2) was measured in 9

> controls, 6 patients with MSA, 13 with ILOCA, 31

> with Parkinson's disease, and 7 with SCA-3. HVR was

> 0.51 in controls, 0.09 in MSA patients, 0.47 in

> ILOCA patients (range 0-1.4), 0.16 in PD patients,

> and 0.59 in SCA-3 patients. Of 7 ILOCA patients

> whose HVR values were less than 0.3, 6 progressed to

> MSA-C within 3 years. No ILOCA patients with values

> above this did.

>

> Copyright 2002 WE MOVE

> Editor: (rrobinson@...)

> -

> Your E-MOVE news subscription is provided free of

> charge, courtesy of

> WE MOVE. PRIVATE DONATIONS ARE NEEDED TO SUPPORT WE

> MOVE's VALUABLE,

> FREE SERVICES LIKE THIS ELECTRONIC NEWS SERVICE.

> Donate online at

> http://www.wemove.org, or send your tax-deductible

> contribution to

> WE MOVE, 204 West 84th Street New York, NY 10024.

> TEL 800-437-MOV2

> or 212- 875-8312. Thank you so much!

> -

> This document may be freely redistributed by email

> only in its

> unedited form. We encourage you to share it with

> your colleagues.

> Visit http://www.wemove.org/emove for E-MOVE

> archives and information

> on subscribing to E-MOVE. To unsubscribe, visit

> http://www.wemove.org/emove/unsubscribe.asp.

> -

> WE MOVE

> 204 West 84th Street

> New York, NY 10024

> TEL 800-437-MOV2

> TEL

> FAX

>

>

>

______________________________________________________________________

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