Guest guest Posted February 17, 2008 Report Share Posted February 17, 2008 I googled vit E high dosage and there are several articles stating that higher doses of vit E can increase mortality in adults. Im not so sure they are from reliable sources but have any of you that are giving these done research on the risks? Are doctors recommending it? I am considering trying the vit E supps but a little concerned about such high doses... Anyone else have/ had these concerns? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2008 Report Share Posted February 18, 2008 Hey, I was concerned about this as well. I just received The LCP Solution by B. Stordy, and it had so much helpful information about fish oil supplementation and vitamin E as well. It was published in 2000. I definitely recommend it to anyone new to this! It really gave a great explanation of the importance of EFAs and why we have deficiency in them. Anyway, about the Vitamin E. Here's an excerpt from the book re this: I've heard that vitamin E can be toxic in large quantities. Is this true? It is very difficult to take too much of a water-soluble vitamin - because the body readily excretes any excess. But it is more difficult to rid the body of an excess of fat- soluble vitamin like A, D, and E. The dangers of excess A and D are well recognized, but very few adverse effects from too much vitamin E have been observed. The Council for Responsible Nutrition in Washington, D.C., has said that vitamin E can be consumed in daily amounts as high as 66 IU (international units) per pound of body weight. For a three-year-old child this is equivalent to about 3,000 IU per day. Concerned parents, knowing the weight of their child, can easily calculate whether there is an appropriate amount of vitamin E in a supplement. Many manufacturers now give vitamin E content by weight rather than the old- fashioned international units. One IU of vitamin E is equivalent to 0.67 milligrams of tocopherol equivalents. (Tocopherol is the chemical name for vitamin E. The term " tocopherol equivalents " is used because there are eight tocopherol compounds that have slightly different chemical structures, but all have vitamin E activity in the body.) So, 300 IU would be 201 milligrams of vitamin E. Hope this helps! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 18, 2008 Report Share Posted February 18, 2008 Society pushes us to drive through fast food pit stops so we don't even have to get out of the car and walk to our saturated fatty food dinners... and warns us against too much vitamin E? Below is an archive on an abstract written by Dr. and Dr. Agin -as well as a post from Dr. about the dosage for vitamin E. Abstract Dr. and Dr. Agin wrote Presented as an oral presentation at the Annual Meeting of the Pediatric Academy Societies, (Late-Breaking Platform Session) Toronto, Cananda May 2007. Title: Impact Of Vitamin E And Omega 3 Supplementation In Children With Verbal Apraxia R , MD1 and Marilyn C Agin, MD. 1Emergency Medicine, Children's Hospital & Research Center Oakland, Oakland, CA, United States. Background: Verbal apraxia (VA) is a neurologically-based motor planning disorder of unknown etiology common in autism spectrum disorders (ASD) that anecdotally responds to omega 3 polyunsaturated fatty acid (PUFA) supplementation. Vitamin (vit) E deficiency causes symptoms that overlap those of VA. PUFAs in the cell membrane are vulnerable to lipid peroxidation early destruction if vit E is not readily available, potentially leading to neurological sequelae. Inflammation of the gastrointestinal tract and gluten sensitivity may contribute to malabsorption of nutrients such as vit E and carnitine, contributing to fatty acid metabolism dysfunction and neurological abnormalities. Objective: Determine efficacy of vit E and PUFA supplementation in children with VA. Design/Methods: 50 children diagnosed with VA were treated with vit E + PUFA. 10 of these children were known to have ASD. A celiac panel, fat soluable vitamins, carnitine level was obtained in patients having blood analyzed. Results: Age ranged from 2-13 years, (majority < 5 yrs), 38/50 were boys. A history of gastrointestinal symptoms, sensory integration dysfunction, low muscle tone coordination difficulties (dyspraxia) were commonly reported. 48 families (96%) anecdotally reported dramatic improvements in a number of areas including speech, imitation, coordination, eye contact, behavior, sensory issues the development of pain sensation. 2 children experienced new tearful or aggressive behavior within 3 days of initiating vit E (400 IU/d) without apparent benefits in speech, therapy was withdrawn within a week. No other adverse effects were reported. Plasma alpha tocopherol levels varied in children tested (low in 2, high in 4 and normal in 4), however pre-treatment levels did not reflect clinical response. Low plasma carnitine was identified in 13/14 (93%) children. Antigliadin IgG antibodies were high in 9/11 (82%) children tested. 2 children reported vit D deficiency early signs of rickets. Conclusions: We describe a new disease paradigm of abnormal vit E fatty acid metabolism causing neurological dysfunction in VA that responds to a safe nutritional intervention. The association of carnitine deficiency gluten sensitivity with VA is a novel observation, suggesting that these children deserve a more comprehensive metabolic work-up than what is current standard practice. Larger controlled trials in apraxia autism are warranted. ~~~~~~~~~~~~~~~~start of archives from Dr. The reason no one has heard about vit E and apraxia is because my son was the first to benefit from this discovery...and it was the combination of mom with apraxic child...watching all his neurological deficits and trying to find the pieces of the puzzle to explain his condition. I don't expect that you will hear about this anywhere else until I get around to publishing a case report...and we find funding to do a proper study. Regarding fish oil. FISH OIL IS SAFE!!! It is terrible that even " knowledgable " people give out misinformation. A can of sardines has > 6 grams of omegas (and most will boast this fact on the label). Would the nutritionalist warn against sardines? Where is the fear of fatty fried fast food? Mcs and Burger King are household terms. There is danger in all the " bad fat " . The fear is totally misplaced. We should be more worried about a society of children on ritalin...given the good support in the literature that omega 3 supplements may be just as effective for some kids with ADHD. If you are seeing a benefit with fish oil, don't worry about it. And safe levels for vitamin E are as high as 1 gram (1500 iu). Our children ARE DIFFERENT. Not only are these supplements good for the heart, but it appears they are good for the brain. For whatever reason our children's brains respond to these supplements. For whatever reason, my son had neurological symptoms that completely overlapped disease conditions of severe vitamin E deficiency. Now treated with high dose vit E/omega 3...he is a totally normal little guy - once severely apraxic...completely unintellibile and totally uncoordinated just 1 year ago. Things are so different now. It is just so frustrating to see all this misinformation circulated...scaring parents away from totally benign interventions that could significantly help their children. - And here is the answer to the question from Dr. : The big question is whether vit E is having an adverse effect on vit K. You should definitely be supplementing with Vit K as well. We use Life Extensions Super K with K2. You can give it once a day. Plasma levels (though helpful to follow) still do not reflect vit E levels in the organs that essentially need them (like brain and muscle). If it makes you nervous, you can decrease by 200 iu...and when/if you see regression...bump back up. The interesting thing about the vit E regression is that it seems completely and quickly reversible! ~~~~~~~~~~~~~~~~~~~~end of archives ===== Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2008 Report Share Posted February 19, 2008 I know Dr. is directly involved with and completely on top of this issue, both as parent, doctor, and researcher. I trust her judgment, her expertise, and her experience. It is worth noting that The Mayo Clinic's website shows tolerable upper limits of Vit. E for children 1-3 years old as 300 IUs/day (and for children ages 4-8 as 450 IUs/day.) Many of our children apparently are either deficient in Vit E or are failing to absorb or utilize their total intake, for whatever reason. From reading here, I understand that Dr. has found that doses greater than the published tolerable upper limits are therapeutic for some of our kids. That said, I remain cautious and reluctant to go beyond the upper limits. My position, of course, may change down the road upon further testing and medical input. But, my daughter's initial behavioral reaction to only 100 IUs was extreme, so we've chosen to hold off for now. > > Society pushes us to drive through fast food pit stops so we don't > even have to get out of the car and walk to our saturated fatty food > dinners... and warns us against too much vitamin E? > > Below is an archive on an abstract written by Dr. and Dr. > Agin -as well as a post from Dr. about the dosage for vitamin > E. > > Abstract Dr. and Dr. Agin wrote > > Presented as an oral presentation at the Annual Meeting of the > Pediatric Academy Societies, (Late-Breaking Platform Session) > Toronto, Cananda May 2007. > > Title: Impact Of Vitamin E And Omega 3 Supplementation In Children > With Verbal Apraxia > R , MD1 and Marilyn C Agin, MD. 1Emergency Medicine, > Children's Hospital & Research Center Oakland, Oakland, CA, United > States. > > Background: Verbal apraxia (VA) is a neurologically-based motor > planning disorder of unknown etiology common in autism spectrum > disorders (ASD) that anecdotally responds to omega 3 polyunsaturated > fatty acid (PUFA) supplementation. Vitamin (vit) E deficiency causes > symptoms that overlap those of VA. PUFAs in the cell membrane are > vulnerable to lipid peroxidation early destruction if vit E is not > readily available, potentially leading to neurological sequelae. > Inflammation of the gastrointestinal tract and gluten sensitivity may > contribute to malabsorption of nutrients such as vit E and carnitine, > contributing to fatty acid metabolism dysfunction and neurological > abnormalities. > Objective: Determine efficacy of vit E and PUFA supplementation in > children with VA. > Design/Methods: 50 children diagnosed with VA were treated with vit E > + PUFA. 10 of these children were known to have ASD. A celiac panel, > fat soluable vitamins, carnitine level was obtained in patients > having blood analyzed. > Results: Age ranged from 2-13 years, (majority < 5 yrs), 38/50 were > boys. A history of gastrointestinal symptoms, sensory integration > dysfunction, low muscle tone coordination difficulties (dyspraxia) > were commonly reported. 48 families (96%) anecdotally reported > dramatic improvements in a number of areas including speech, > imitation, coordination, eye contact, behavior, sensory issues the > development of pain sensation. 2 children experienced new tearful or > aggressive behavior within 3 days of initiating vit E (400 IU/d) > without apparent benefits in speech, therapy was withdrawn within a > week. No other adverse effects were reported. Plasma alpha tocopherol > levels varied in children tested (low in 2, high in 4 and normal in > 4), however pre-treatment levels did not reflect clinical response. > Low plasma carnitine was identified in 13/14 (93%) children. > Antigliadin IgG antibodies were high in 9/11 (82%) children tested. 2 > children reported vit D deficiency early signs of rickets. > Conclusions: We describe a new disease paradigm of abnormal vit E > fatty acid metabolism causing neurological dysfunction in VA that > responds to a safe nutritional intervention. The association of > carnitine deficiency gluten sensitivity with VA is a novel > observation, suggesting that these children deserve a more > comprehensive metabolic work-up than what is current standard > practice. Larger controlled trials in apraxia autism are warranted. > > ~~~~~~~~~~~~~~~~start of archives from Dr. > > The reason no one has heard about vit E and apraxia is because my > son was the first to benefit from this discovery...and it was the > combination of mom with apraxic child...watching all his > neurological deficits and trying to find the pieces of the puzzle to > explain his condition. I don't expect that you will hear about this > anywhere else until I get around to publishing a case report...and > we find funding to do a proper study. > > Regarding fish oil. FISH OIL IS SAFE!!! It is terrible that > even " knowledgable " people give out misinformation. A can of > sardines has > 6 grams of omegas (and most will boast this fact on > the label). Would the nutritionalist warn against sardines? > > Where is the fear of fatty fried fast food? Mcs and Burger > King are household terms. There is danger in all the " bad fat " . > > The fear is totally misplaced. We should be more worried about a > society of children on ritalin...given the good support in the > literature that omega 3 supplements may be just as effective for > some kids with ADHD. > > If you are seeing a benefit with fish oil, don't worry about it. And > safe levels for vitamin E are as high as 1 gram (1500 iu). Our > children ARE DIFFERENT. Not only are these supplements good for the > heart, but it appears they are good for the brain. For whatever > reason our children's brains respond to these supplements. For > whatever reason, my son had neurological symptoms that completely > overlapped disease conditions of severe vitamin E deficiency. Now > treated with high dose vit E/omega 3...he is a totally normal little > guy - once severely apraxic...completely unintellibile and totally > uncoordinated just 1 year ago. Things are so different now. It is > just so frustrating to see all this misinformation > circulated...scaring parents away from totally benign interventions > that could significantly help their children. > > - > > And here is the answer to the question from Dr. : > > The big question is whether vit E is having an adverse effect on vit > K. You should definitely be supplementing with Vit K as well. > > We use Life Extensions Super K with K2. You can give it once a day. > Plasma levels (though helpful to follow) still do not reflect vit E > levels in the organs that essentially need them (like brain and > muscle). If it makes you nervous, you can decrease by 200 iu...and > when/if you see regression...bump back up. The interesting thing > about the vit E regression is that it seems completely and quickly > reversible! > ~~~~~~~~~~~~~~~~~~~~end of archives > > > ===== > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 19, 2008 Report Share Posted February 19, 2008 No doubt about it, Dr. knows this stuff. Thing is, many on this list supplement E without considering the testing she mentions and they do not rule in or out celiac and other conditions. She mentioned in one post that some bleeding can be associated with that. In the end it is unrealistic to not investigate our own individual children. Quote Link to comment Share on other sites More sharing options...
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