RESEARCH: Progression, Hypoxia Response

[Guest guest]

MSA: Progression, Hypoxia Response

1. Progression and prognosis in multiple system atrophy: An analysis of 230

Japanese patients

H Watanabe, Y Saito, S Terao, T Ando, T Kachi, E Mukai, I Aiba, Y Abe, A

Tamakoshi, M Doyu, M Hirayam, G Sobue

Brain 2002;125:1070-1083

The interval from symptom onset to combined motor and autonomic dysfunction

is predictive of functional deterioration and survival in MSA, according to

this study.

Consensus criteria were used to identify 230 patients with MSA, of whom 131

were male. Mean age of onset was 55.4 years. Cerebellar symptoms (MSA-C)

predominated in 155 patients, while parkinsonian symptoms (MSA-P) were most

prominent in 75. The median time from symptom onset to multi-system

involvement was 2 years. Median survival time was 9.0 years (range 2-17

years). Time to assisted walking, wheelchair requirement, bed confinement,

and death were proportional to time between symptom onset and multisystem

involvement. Patients in whom multisystem involvement occurred within one

year of symptom onset proceeded to each of these milestones 2-3 times as

fast as those for whom multisystem involvement occurred after 3 years or

more.

2. Impaired chemosensitivity to hypoxia is a marker of multiple system

atrophy

T Suda, H Onodera, S Okabe, Y Kikuchi, Y Itoyama

Ann Neurol 2002;52:367-371

Impaired ventilatory response to hypoxia can help predict whether patients

with idiopathic late-onset cerebellar ataxia will progress to MSA-C,

according to this study.

Hypoxia ventilatory response (change in respiratory rate versus change in

blood O2) was measured in 9 controls, 6 patients with MSA, 13 with ILOCA, 31

with Parkinson's disease, and 7 with SCA-3. HVR was 0.51 in controls, 0.09

in MSA patients, 0.47 in ILOCA patients (range 0-1.4), 0.16 in PD patients,

and 0.59 in SCA-3 patients. Of 7 ILOCA patients whose HVR values were less

than 0.3, 6 progressed to MSA-C within 3 years. No ILOCA patients with

values above this did.

Copyright 2002 WE MOVE

Editor: (rrobinson@...)

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New York, NY 10024

TEL 800-437-MOV2

TEL

FAX

[Guest guest]

MSA: Progression, Hypoxia Response

1. Progression and prognosis in multiple system atrophy: An analysis of 230

Japanese patients

H Watanabe, Y Saito, S Terao, T Ando, T Kachi, E Mukai, I Aiba, Y Abe, A

Tamakoshi, M Doyu, M Hirayam, G Sobue

Brain 2002;125:1070-1083

The interval from symptom onset to combined motor and autonomic dysfunction

is predictive of functional deterioration and survival in MSA, according to

this study.

Consensus criteria were used to identify 230 patients with MSA, of whom 131

were male. Mean age of onset was 55.4 years. Cerebellar symptoms (MSA-C)

predominated in 155 patients, while parkinsonian symptoms (MSA-P) were most

prominent in 75. The median time from symptom onset to multi-system

involvement was 2 years. Median survival time was 9.0 years (range 2-17

years). Time to assisted walking, wheelchair requirement, bed confinement,

and death were proportional to time between symptom onset and multisystem

involvement. Patients in whom multisystem involvement occurred within one

year of symptom onset proceeded to each of these milestones 2-3 times as

fast as those for whom multisystem involvement occurred after 3 years or

more.

2. Impaired chemosensitivity to hypoxia is a marker of multiple system

atrophy

T Suda, H Onodera, S Okabe, Y Kikuchi, Y Itoyama

Ann Neurol 2002;52:367-371

Impaired ventilatory response to hypoxia can help predict whether patients

with idiopathic late-onset cerebellar ataxia will progress to MSA-C,

according to this study.

Hypoxia ventilatory response (change in respiratory rate versus change in

blood O2) was measured in 9 controls, 6 patients with MSA, 13 with ILOCA, 31

with Parkinson's disease, and 7 with SCA-3. HVR was 0.51 in controls, 0.09

in MSA patients, 0.47 in ILOCA patients (range 0-1.4), 0.16 in PD patients,

and 0.59 in SCA-3 patients. Of 7 ILOCA patients whose HVR values were less

than 0.3, 6 progressed to MSA-C within 3 years. No ILOCA patients with

values above this did.

Copyright 2002 WE MOVE

Editor: (rrobinson@...)

-

Your E-MOVE news subscription is provided free of charge, courtesy of

WE MOVE. PRIVATE DONATIONS ARE NEEDED TO SUPPORT WE MOVE's VALUABLE,

FREE SERVICES LIKE THIS ELECTRONIC NEWS SERVICE. Donate online at

http://www.wemove.org, or send your tax-deductible contribution to

WE MOVE, 204 West 84th Street New York, NY 10024. TEL 800-437-MOV2

or 212- 875-8312. Thank you so much!

-

This document may be freely redistributed by email only in its

unedited form. We encourage you to share it with your colleagues.

Visit http://www.wemove.org/emove for E-MOVE archives and information

on subscribing to E-MOVE. To unsubscribe, visit

http://www.wemove.org/emove/unsubscribe.asp.

-

WE MOVE

204 West 84th Street

New York, NY 10024

TEL 800-437-MOV2

TEL

FAX