Retinaldehyde (was cea and topical retinoids.)

[Guest guest]

Thanks, Tom. I don't know if this is what Ian is talking about, since

this is on retinaldehyde. But this is interesting information.

You're right, the first " study " has obvious design flaws. The

abstract isn't written in traditional format (like the second study)

so I wonder if this was a contribution rather than a full study -- an

option editors give some authors if their study doesn't pass muster

but contains interesting information for the readers. Alternatively,

since this was in a supplemental edition of the Journal, it may have

been part of a symposium, which also doesn't carry the same weight as

a full published study. The statistics in the second study, esp

considering the small number of subjects, shows essentially no

difference.

I don't see the year in the second study but its references are all

before 1999, the date of the first article. Nothing more current on

retinaldehyde in the literature?

Marjorie

Marjorie Lazoff, MD

> > >

> > > Hi group.

> > > This is the first time i post but i have had private contact

with

> > > some of you,Hello Dr Majorie, she knows me as the one who calls

> > > himself a doctor.

> > > My name is Ian and i am acctually a Doctor in medicine, i am

> > willing

> > > to help as much as i can so feel free to ask and i will get

back

> to

> > > you as soon as possible,

> > > I will like to say something about Matijas articule because it

> > seems

> > > ironic but is a matter of fact, is well known that retinoic

acid

> is

> > > not a good choice for people with sensitive skin, Not many

years

> > ago

> > > if a Dr was thinking in retinoic acid as a choice for rosacea

the

> > > medical comunity would of think of a joke or maybe a mistake

> > because

> > > the rosacea is by some considered as some type of acne or adult

> > acne

> > > other investigations say that they look alike and sometimes

> > coesxist

> > > but they are totally diferent diseases if you think about it

who

> is

> > > who to decide or determine if nobody knows the cause of

rosacea,

> i

> > > believe that is multifactorial begining like all diseases with

a

> > > genetic charge, in a personal point of view i think there might

> be

> > > even diferent causes or types of rosacea and maybe that is why

> some

> > > people responds well to some drugs and others not respond or

> > respond

> > > in a paradoxicall or oposite way, and theories there is the

> > > neurovascular, the demodex mites, the altered temperture

> regulation

> > > by the hypotalamus,The H pylori as the responsable, the gluten

an

> > > inmune mediated etc at least we have ideas, although sometimes

it

> > > feels like we are confused and choosing a dark, wrong direccion

> in

> > > the plans of investigation because although i am not American

> there

> > > are some 13 millions of rosaceans only in United States even

the

> > > expresident has rosacea plus 2 million of Canadians,

Australians

> > and

> > > many in Europe and nobody knows what is going on many times i

> feel

> > > frustrated when i read a Book or an articule wich comfirms that

> > > rosacea is perfectly controled with Metrogel, Dont get me wrong

> > there

> > > are doctors that have being of great help like Dr Nase sadly he

> > have

> > > to had it to understand the impact of rosacea.

> > > Sorry i am loosing the purpose of these post, in recient

> > > investigations retinoic acid at 0.5% or tretinoin at 0.025 at

> > bedtime

> > > combined with the anibiotic clindamicine in the morning has

being

> a

> > > what i call crazy good choice, why crazy because retinoids are

> well

> > > known as pro angiogenics, vasodilators and irritants all that

is

> a

> > no

> > > no for rosaceans the irony is that after 6 months of clinical

> > trials

> > > and at diferent concentrations retinoic acid improved the

> > > papulopustular component of rosacea but it had a better impact

in

> > > decreasing the redness, and the telangiectasia, inflamation in

> > > general and also improved rosacea with post-inflamatory

lessions

> or

> > > pigmented areas also caused by solar damaged this is because

> > > retinoids interfiere with the melanosomes that carry

melanocites

> to

> > > the dermis and epidermis, In a personal experience i had being

> > using

> > > isotretinoin the same substance as accutane but in a cream base

> > wich

> > > is less irritating than tretinoin and sometimes i like to

combine

> > it

> > > with topical ketoconazol or an antibiotic like clindamicine or

> > > erytromicine results are good but again in my personal

experience.

> > > With rosacea we never know what to expect lets play by it rules

> > lets

> > > try unexpectable treatments with unexpectable results lets stop

> and

> > > think why continue with something that is not working, i

learned

> > that

> > > living with this condition makes you choose between becoming a

> > victim

> > > of some kind of bad karma or become wisely crazy meaning to be

> able

> > > to laugh at yourself just to reduce the pain and the stress

> > accepting

> > > the fact that there is a problem like many others in life that

> took

> > > you to modify your expectations but never the meaning that you

> gave

> > > to your life once, i guess that if i dont take it crazy i will

> be

> > > the one ending up crazy, i am not saying it shouldnt be taken

> > > seriously and with smart, secure treatments i have heard of

> rosacea

> > > being treated with zofran wich i dont understand besides the

> price

> > > the drug blocks serotonin and serotonin is a vasoregulator many

> > times

> > > responsable for depression and migrain headaches wich is

> basically

> > a

> > > cycle of vasodilation and vasoconstriccion also asociated with

> > > rosacea.

> > > I want to tell you all that we share and understand the same

pain

> > > that maybe we dont know how are we going to feel some day but

for

> > > shure there are things that are going to make us feel better, i

> say

> > > lets keep the eyes shining, we are part of the world and things

> > > sometimes are harder for us,sometimes we are judged by people

of

> > > complaining, of being wrong,victims, how many times i end up

> > lifting

> > > shadows of broken dreams, insecure of what i am doing, not

> sleeping

> > > wondering if my life has sense, but i am shure we are not

> cowards,

> > we

> > > fight, we are warriors sometimes defeated,sad,hopeless all of

> that

> > > are part of all fighter but we still believe, we look for a

> meaning

> > > and search for the cause because we ask and some day we will

know.

> > > Take care, sorry but english is not my language hope you

> understand.

> > > Dr Ian Alarcon.

[Guest guest]

Thanks, Tom. I don't know if this is what Ian is talking about, since

this is on retinaldehyde. But this is interesting information.

You're right, the first " study " has obvious design flaws. The

abstract isn't written in traditional format (like the second study)

so I wonder if this was a contribution rather than a full study -- an

option editors give some authors if their study doesn't pass muster

but contains interesting information for the readers. Alternatively,

since this was in a supplemental edition of the Journal, it may have

been part of a symposium, which also doesn't carry the same weight as

a full published study. The statistics in the second study, esp

considering the small number of subjects, shows essentially no

difference.

I don't see the year in the second study but its references are all

before 1999, the date of the first article. Nothing more current on

retinaldehyde in the literature?

Marjorie

Marjorie Lazoff, MD

> > >

> > > Hi group.

> > > This is the first time i post but i have had private contact

with

> > > some of you,Hello Dr Majorie, she knows me as the one who calls

> > > himself a doctor.

> > > My name is Ian and i am acctually a Doctor in medicine, i am

> > willing

> > > to help as much as i can so feel free to ask and i will get

back

> to

> > > you as soon as possible,

> > > I will like to say something about Matijas articule because it

> > seems

> > > ironic but is a matter of fact, is well known that retinoic

acid

> is

> > > not a good choice for people with sensitive skin, Not many

years

> > ago

> > > if a Dr was thinking in retinoic acid as a choice for rosacea

the

> > > medical comunity would of think of a joke or maybe a mistake

> > because

> > > the rosacea is by some considered as some type of acne or adult

> > acne

> > > other investigations say that they look alike and sometimes

> > coesxist

> > > but they are totally diferent diseases if you think about it

who

> is

> > > who to decide or determine if nobody knows the cause of

rosacea,

> i

> > > believe that is multifactorial begining like all diseases with

a

> > > genetic charge, in a personal point of view i think there might

> be

> > > even diferent causes or types of rosacea and maybe that is why

> some

> > > people responds well to some drugs and others not respond or

> > respond

> > > in a paradoxicall or oposite way, and theories there is the

> > > neurovascular, the demodex mites, the altered temperture

> regulation

> > > by the hypotalamus,The H pylori as the responsable, the gluten

an

> > > inmune mediated etc at least we have ideas, although sometimes

it

> > > feels like we are confused and choosing a dark, wrong direccion

> in

> > > the plans of investigation because although i am not American

> there

> > > are some 13 millions of rosaceans only in United States even

the

> > > expresident has rosacea plus 2 million of Canadians,

Australians

> > and

> > > many in Europe and nobody knows what is going on many times i

> feel

> > > frustrated when i read a Book or an articule wich comfirms that

> > > rosacea is perfectly controled with Metrogel, Dont get me wrong

> > there

> > > are doctors that have being of great help like Dr Nase sadly he

> > have

> > > to had it to understand the impact of rosacea.

> > > Sorry i am loosing the purpose of these post, in recient

> > > investigations retinoic acid at 0.5% or tretinoin at 0.025 at

> > bedtime

> > > combined with the anibiotic clindamicine in the morning has

being

> a

> > > what i call crazy good choice, why crazy because retinoids are

> well

> > > known as pro angiogenics, vasodilators and irritants all that

is

> a

> > no

> > > no for rosaceans the irony is that after 6 months of clinical

> > trials

> > > and at diferent concentrations retinoic acid improved the

> > > papulopustular component of rosacea but it had a better impact

in

> > > decreasing the redness, and the telangiectasia, inflamation in

> > > general and also improved rosacea with post-inflamatory

lessions

> or

> > > pigmented areas also caused by solar damaged this is because

> > > retinoids interfiere with the melanosomes that carry

melanocites

> to

> > > the dermis and epidermis, In a personal experience i had being

> > using

> > > isotretinoin the same substance as accutane but in a cream base

> > wich

> > > is less irritating than tretinoin and sometimes i like to

combine

> > it

> > > with topical ketoconazol or an antibiotic like clindamicine or

> > > erytromicine results are good but again in my personal

experience.

> > > With rosacea we never know what to expect lets play by it rules

> > lets

> > > try unexpectable treatments with unexpectable results lets stop

> and

> > > think why continue with something that is not working, i

learned

> > that

> > > living with this condition makes you choose between becoming a

> > victim

> > > of some kind of bad karma or become wisely crazy meaning to be

> able

> > > to laugh at yourself just to reduce the pain and the stress

> > accepting

> > > the fact that there is a problem like many others in life that

> took

> > > you to modify your expectations but never the meaning that you

> gave

> > > to your life once, i guess that if i dont take it crazy i will

> be

> > > the one ending up crazy, i am not saying it shouldnt be taken

> > > seriously and with smart, secure treatments i have heard of

> rosacea

> > > being treated with zofran wich i dont understand besides the

> price

> > > the drug blocks serotonin and serotonin is a vasoregulator many

> > times

> > > responsable for depression and migrain headaches wich is

> basically

> > a

> > > cycle of vasodilation and vasoconstriccion also asociated with

> > > rosacea.

> > > I want to tell you all that we share and understand the same

pain

> > > that maybe we dont know how are we going to feel some day but

for

> > > shure there are things that are going to make us feel better, i

> say

> > > lets keep the eyes shining, we are part of the world and things

> > > sometimes are harder for us,sometimes we are judged by people

of

> > > complaining, of being wrong,victims, how many times i end up

> > lifting

> > > shadows of broken dreams, insecure of what i am doing, not

> sleeping

> > > wondering if my life has sense, but i am shure we are not

> cowards,

> > we

> > > fight, we are warriors sometimes defeated,sad,hopeless all of

> that

> > > are part of all fighter but we still believe, we look for a

> meaning

> > > and search for the cause because we ask and some day we will

know.

> > > Take care, sorry but english is not my language hope you

> understand.

> > > Dr Ian Alarcon.