Information about retinoids.

July 4, 2002

Hello everybody:

Hope things are doing well, I will like to apologyse to Dr Majorie if

i ofend her in some way i can honestly say that it is not my

intention, this is a group, a team that shares the same condition and

thats enough to look at it in a possitive way, we all want to feel

better and thats all there is to it even for the next generations.

Just dont get mad Dr Majorie in all games the mad is the one who

looses, i remember that the first thing you learn in medical school

is to respect your collegues, if you dont have anything possitive to

say about a partner dont lie but keep it quiet, not only for ethics

just because we are humans and we will make a mistake sometime, I

find it dissapointing that Dr Majorie with all the respect she

deserves since i think she is wise,caring,bright, and experienced,

puts in doubt my credibility when we have had contact one or two

times only, thats not acceptable in anyway.

well here are some of the references from the articules you were

asking me for.

INHIBITORY EFFECT OF RETINOIDS ON THE VASCULAR ENDOTHELIAL GROWTH

FACTOR PRODUCED BY HUMAN KERATINOCYTES.

LACHGAR-DERMATOLOGY 01-JANUARY-1999.

FROM NIH-NLM MEDLINE.

NLM CITATION IP

1047 3956 (PUBMED)

99 40 640(MEDLINE)

PUBLICATION:JOURNAL ARTICLE

AUTHORS:lACHGAR S,CHAVERON M,GALLY.

CONCLUSSION:VEGF EXPRESSION BY KERATINOCYTES ON CONTACT WITH

RETINOIDS AT DIFERENT CONCENTRATIONS STRONGLY REDUCED SKIN CAPACITY

TO PERFORM NEOANGIOGENESIS IN ROSACEA AND OTHER DERMATOSiS.

2) RETINOIDS-WICH INDICATIONS WILL BENEFIT IN THE NEAR FUTURE.

ZOBULISCC-SKIN PHARMACOLOGY AND SKIN APPLIED PHYSIOLOGY-2001.

FROM NLH MEDLINE-21470564.

AFFILIATION:DEPARTMENT OF DERMATOLOGY, UNIVERSITY MEDICAL CENTER,

BENJAMIN FRANKLIN, BERLIN GERMANY.

REFERENCES 90.

TOPICAL TRETINOIN,RETINALDDEHYDE,ADAPELEN,ISOTRETINOIN,BEXOROTENE ARE

USED IN MANY DERMATOSIS AND HAD BEEN SUCCESFULLY USED IN ROSACEA AND

ACNEIFORM DISORDERS.

3)RETINALDHEYDE ALLEVIATES ROSACEA.

VIENNE MP-DERMATOLOGY-01-01-99.

FROM NLH MEDLINE.

NLH CITATION ID:99-406446.

PUBLICATION TYPE:CLINICAL TRIAL, CONTROLLED CLINICAL TRIAL.

JOURNAL ARTICULE:

CONCLUSION: RETINOIC ACID HAS BENEFICAL EFFECTS ON THE VASCULAR

COMPONENT OF ROSACEA.

4)REPAIR UVA ELASTIC AND COLLAGEN FIBER DAMAGED WITH 0.05%

RETINALDEHYDE CREAM.

FROM NLH MEDLINE.

JOURNAL ARTICULE.

AUTHOR AFFILIATION: DEPARTMENT OF PATHOLOGY

HOSPITLE-SALPETIERE, PARIS FRANCE.

AUTHORS:BIOSNIC S,LECHARPEITIER

CONCLUCION:IT HAS BEEN SHOWN THAT RETINALDEHYDE AND TRETINOIN SHARE

THE SAME PROPERTIES IN THEIR BIOLOGICAL AND BENEFICAL EFFECTS BY

INDUCING SPECIALLY ON DERMAL CONECTIVE TISSUE SIGNIFICANT REPAIR OF

ELASTIC AND CONECTIVE FIBERS INDUCED BY SOLAR(UVA) EXPOSURE, IS

CLASSIC THAT A PATHOLOGY REPORT OF A BIOPSY OF ROSACEA SKIN SHOWS

SOLAR ELASTOSIS, THIS STUDY INDICATES THAT RETINOIDS ARE BENEFICAL.

iT LOOKS TO ME THAT CORTICOIDS AND RETINOIDS ACT DIFERENT

CORTICOSTEROIDS THIN, ATROPHY THE SKIN, RETINOIDS THICK, REFILL WITH

COLLAGEN AND ELASTIN, I GUESS THE TRICK WILL BE IN FINDING A RETINOID

THAT WOULD BE BETTER TOLERATED FOR US.

There are many related articules in mdconsult, ovid, etc i am just

very tiered hope this will be of help for you and all.

Dr Ian Alarcon.

July 4, 2002