Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 I wanted to put in my two cents regarding topical retinoids and rosacea. I've been lurking here for months and have seen time and time again a huge bias against their use, with many a poster offhandedly dismissing their use as unsuitable for rosacea. I'm not a doctor, nor do I play one on television, but I am a professional researcher. I have researched the medical literature extensively, and not only have I not seen any evidence that topical retinoids are harmful for rosacea, but, to the contrary, have seen numerous studies supporting their use. Most of these relate to its effectiveness against the papopustular component. In addition, though, there seems to be strong evidence that the use of topical retinoids discourages the action of VEGF, the compound that promotes angiogenesis. In fact, studies of the use of retinoids to treat cancers (by inhibiting the growth of vessels to supply blood to a tumor) have begun to appear. The only evidence I have seen on this board or elsewhere that supports the view that topical retinoids shuld be avoided is the fact that they can be irritating, and that Dr. Nase says they're bad. This is in contrast to the amount of concrete scientific evidence that points to thier effectiveness in rosacea. I was diagnosed with rosacea two years ago, and have been on retin-a since the beginning. my skin is smooth, pale, clear, and my pores are small. Before treatment I had both redness and breakouts. Not implying that they're for everyone. But, unlike many of the treatment options that are discussed on this board, there is a scientific literature addressing the action and usage of topical retinoids, and so am encouraging a fully informed, unbiased discussion of their merits. By the by, would be happy to send along relevant citations. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 I wanted to put in my two cents regarding topical retinoids and rosacea. I've been lurking here for months and have seen time and time again a huge bias against their use, with many a poster offhandedly dismissing their use as unsuitable for rosacea. I'm not a doctor, nor do I play one on television, but I am a professional researcher. I have researched the medical literature extensively, and not only have I not seen any evidence that topical retinoids are harmful for rosacea, but, to the contrary, have seen numerous studies supporting their use. Most of these relate to its effectiveness against the papopustular component. In addition, though, there seems to be strong evidence that the use of topical retinoids discourages the action of VEGF, the compound that promotes angiogenesis. In fact, studies of the use of retinoids to treat cancers (by inhibiting the growth of vessels to supply blood to a tumor) have begun to appear. The only evidence I have seen on this board or elsewhere that supports the view that topical retinoids shuld be avoided is the fact that they can be irritating, and that Dr. Nase says they're bad. This is in contrast to the amount of concrete scientific evidence that points to thier effectiveness in rosacea. I was diagnosed with rosacea two years ago, and have been on retin-a since the beginning. my skin is smooth, pale, clear, and my pores are small. Before treatment I had both redness and breakouts. Not implying that they're for everyone. But, unlike many of the treatment options that are discussed on this board, there is a scientific literature addressing the action and usage of topical retinoids, and so am encouraging a fully informed, unbiased discussion of their merits. By the by, would be happy to send along relevant citations. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 , thanks for adding your perspective to the discussion. I hope you've been following all the recent threads on tretinoins. Do you have additional information to add to our discussion regarding retinaldehydes, the use of steroids and tretinoins together, or the efficacy of retinol (the non-prescription form)? You sound impressed by Langhar's tretinoin inhibits VEGF study described in that 1999 Dermatology article. I understand the theoretical connection, but are you aware of any research or other evidence supporting the link between neoangiogenesis or VEFG with rosacea? Or anything regarding tretinoin's effects on the vascular component of rosacea? I also respect the power of medical research but I know it isn't the whole answer. So many studies are biased, incomplete, or inaccurate. Evidence-based medicine tries to address those limitations, but it too has problems. I approach all these positive studies on tretinoins like I do everything else: with a healthy dose of skepticism, a strong reliance on the facts and knowledge basics, and logical deduction (common sense). I don't feel that I have all the necessary information with which to form an opinion on tretinoin's efficacy and safety for rosacea. Marjorie Marjorie Lazoff, MD > I wanted to put in my two cents regarding topical retinoids and > rosacea. > > I've been lurking here for months and have seen time and time again a > huge bias against their use, with many a poster offhandedly > dismissing their use as unsuitable for rosacea. > > I'm not a doctor, nor do I play one on television, but I am a > professional researcher. I have researched the medical literature > extensively, and not only have I not seen any evidence that topical > retinoids are harmful for rosacea, but, to the contrary, have seen > numerous studies supporting their use. > > Most of these relate to its effectiveness against the papopustular > component. In addition, though, there seems to be strong evidence > that the use of topical retinoids discourages the action of VEGF, the > compound that promotes angiogenesis. In fact, studies of the use of > retinoids to treat cancers (by inhibiting the growth of vessels to > supply blood to a tumor) have begun to appear. > > The only evidence I have seen on this board or elsewhere that > supports the view that topical retinoids shuld be avoided is the fact > that they can be irritating, and that Dr. Nase says they're bad. > > This is in contrast to the amount of concrete scientific evidence > that points to thier effectiveness in rosacea. > > I was diagnosed with rosacea two years ago, and have been on retin- a > since the beginning. my skin is smooth, pale, clear, and my pores are > small. Before treatment I had both redness and breakouts. > > Not implying that they're for everyone. But, unlike many of the > treatment options that are discussed on this board, there is a > scientific literature addressing the action and usage of topical > retinoids, and so am encouraging a fully informed, unbiased > discussion of their merits. > > By the by, would be happy to send along relevant citations. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 , thanks for adding your perspective to the discussion. I hope you've been following all the recent threads on tretinoins. Do you have additional information to add to our discussion regarding retinaldehydes, the use of steroids and tretinoins together, or the efficacy of retinol (the non-prescription form)? You sound impressed by Langhar's tretinoin inhibits VEGF study described in that 1999 Dermatology article. I understand the theoretical connection, but are you aware of any research or other evidence supporting the link between neoangiogenesis or VEFG with rosacea? Or anything regarding tretinoin's effects on the vascular component of rosacea? I also respect the power of medical research but I know it isn't the whole answer. So many studies are biased, incomplete, or inaccurate. Evidence-based medicine tries to address those limitations, but it too has problems. I approach all these positive studies on tretinoins like I do everything else: with a healthy dose of skepticism, a strong reliance on the facts and knowledge basics, and logical deduction (common sense). I don't feel that I have all the necessary information with which to form an opinion on tretinoin's efficacy and safety for rosacea. Marjorie Marjorie Lazoff, MD > I wanted to put in my two cents regarding topical retinoids and > rosacea. > > I've been lurking here for months and have seen time and time again a > huge bias against their use, with many a poster offhandedly > dismissing their use as unsuitable for rosacea. > > I'm not a doctor, nor do I play one on television, but I am a > professional researcher. I have researched the medical literature > extensively, and not only have I not seen any evidence that topical > retinoids are harmful for rosacea, but, to the contrary, have seen > numerous studies supporting their use. > > Most of these relate to its effectiveness against the papopustular > component. In addition, though, there seems to be strong evidence > that the use of topical retinoids discourages the action of VEGF, the > compound that promotes angiogenesis. In fact, studies of the use of > retinoids to treat cancers (by inhibiting the growth of vessels to > supply blood to a tumor) have begun to appear. > > The only evidence I have seen on this board or elsewhere that > supports the view that topical retinoids shuld be avoided is the fact > that they can be irritating, and that Dr. Nase says they're bad. > > This is in contrast to the amount of concrete scientific evidence > that points to thier effectiveness in rosacea. > > I was diagnosed with rosacea two years ago, and have been on retin- a > since the beginning. my skin is smooth, pale, clear, and my pores are > small. Before treatment I had both redness and breakouts. > > Not implying that they're for everyone. But, unlike many of the > treatment options that are discussed on this board, there is a > scientific literature addressing the action and usage of topical > retinoids, and so am encouraging a fully informed, unbiased > discussion of their merits. > > By the by, would be happy to send along relevant citations. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 > By the by, would be happy to send along relevant citations. YES, please do. We've been posting and trading studies on renova/retin-a effectiveness for rosacea, and any more would be greatly appreciated. thanks trom -- In rosacea-support@y..., " normad826000 " <normad826000@y...> wrote: > I wanted to put in my two cents regarding topical retinoids and > rosacea. > > I've been lurking here for months and have seen time and time again a > huge bias against their use, with many a poster offhandedly > dismissing their use as unsuitable for rosacea. > > I'm not a doctor, nor do I play one on television, but I am a > professional researcher. I have researched the medical literature > extensively, and not only have I not seen any evidence that topical > retinoids are harmful for rosacea, but, to the contrary, have seen > numerous studies supporting their use. > > Most of these relate to its effectiveness against the papopustular > component. In addition, though, there seems to be strong evidence > that the use of topical retinoids discourages the action of VEGF, the > compound that promotes angiogenesis. In fact, studies of the use of > retinoids to treat cancers (by inhibiting the growth of vessels to > supply blood to a tumor) have begun to appear. > > The only evidence I have seen on this board or elsewhere that > supports the view that topical retinoids shuld be avoided is the fact > that they can be irritating, and that Dr. Nase says they're bad. > > This is in contrast to the amount of concrete scientific evidence > that points to thier effectiveness in rosacea. > > I was diagnosed with rosacea two years ago, and have been on retin- a > since the beginning. my skin is smooth, pale, clear, and my pores are > small. Before treatment I had both redness and breakouts. > > Not implying that they're for everyone. But, unlike many of the > treatment options that are discussed on this board, there is a > scientific literature addressing the action and usage of topical > retinoids, and so am encouraging a fully informed, unbiased > discussion of their merits. > > By the by, would be happy to send along relevant citations. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 12, 2002 Report Share Posted July 12, 2002 > By the by, would be happy to send along relevant citations. YES, please do. We've been posting and trading studies on renova/retin-a effectiveness for rosacea, and any more would be greatly appreciated. thanks trom -- In rosacea-support@y..., " normad826000 " <normad826000@y...> wrote: > I wanted to put in my two cents regarding topical retinoids and > rosacea. > > I've been lurking here for months and have seen time and time again a > huge bias against their use, with many a poster offhandedly > dismissing their use as unsuitable for rosacea. > > I'm not a doctor, nor do I play one on television, but I am a > professional researcher. I have researched the medical literature > extensively, and not only have I not seen any evidence that topical > retinoids are harmful for rosacea, but, to the contrary, have seen > numerous studies supporting their use. > > Most of these relate to its effectiveness against the papopustular > component. In addition, though, there seems to be strong evidence > that the use of topical retinoids discourages the action of VEGF, the > compound that promotes angiogenesis. In fact, studies of the use of > retinoids to treat cancers (by inhibiting the growth of vessels to > supply blood to a tumor) have begun to appear. > > The only evidence I have seen on this board or elsewhere that > supports the view that topical retinoids shuld be avoided is the fact > that they can be irritating, and that Dr. Nase says they're bad. > > This is in contrast to the amount of concrete scientific evidence > that points to thier effectiveness in rosacea. > > I was diagnosed with rosacea two years ago, and have been on retin- a > since the beginning. my skin is smooth, pale, clear, and my pores are > small. Before treatment I had both redness and breakouts. > > Not implying that they're for everyone. But, unlike many of the > treatment options that are discussed on this board, there is a > scientific literature addressing the action and usage of topical > retinoids, and so am encouraging a fully informed, unbiased > discussion of their merits. > > By the by, would be happy to send along relevant citations. > > Quote Link to comment Share on other sites More sharing options...
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