RE: Neuroleptic induced Parkinsonism - Deborah

[Guest guest]

Deborah and Pam,

Wow Deborah that is a great article you found. Thank you! My dad never

took any of those drugs either but he did take too much of a prescribed drug

(propoxephene) for a long time for arthritis. We have always felt that this

had something to do with his MSA. We will keep this article and try to find

more information.

Good work Deborah! Pam, thanks for adding the neuroleptic drug info.

Jean (Phoenix)

[Guest guest]

Deborah and Pam,

Wow Deborah that is a great article you found. Thank you! My dad never

took any of those drugs either but he did take too much of a prescribed drug

(propoxephene) for a long time for arthritis. We have always felt that this

had something to do with his MSA. We will keep this article and try to find

more information.

Good work Deborah! Pam, thanks for adding the neuroleptic drug info.

Jean (Phoenix)

[Guest guest]

Deborah,

If you find anything else on the Drug-induced Parkinsons will you share it

with us?

Jean (Phoenix)

[Guest guest]

Deborah,

If you find anything else on the Drug-induced Parkinsons will you share it

with us?

Jean (Phoenix)

[Guest guest]

The information about neuroleptic drug induced Parkinsonianism is not new.

Those drugs have been used for years for Schizophrenia which is the opposite

of Parkinson's since it seems to come from an excess of Dopamine. The

neuroleptic drugs mentioned were specifically designed to cut down on

Dopamine so the obvious result of too much of them was PD symptoms which

usually go away when the drugs are reduced or removed. When a patient with

Parkinson's gets too much Sinemet, the symptoms are often the same as those

of Schizophrenia, and can be sometimes counteracted with a small dose of a

neuroleptic. Also, animal models of Parkinson's are induced with drugs for

researchers to find drugs that will help PD. You may remember a number of

years ago when some people in San Francisco tried to make Heroin in the lab

and got something else that gave them all instant Parkinson's which did not

abate when the drug was withdrawn.

The talk about whether Alcoholism is a factor is interesting because I

have always wondered about it as Ken was a recovered alcoholic. However,

studies that have been done have shown a negative correlation between

Alcoholism and Parkinson's which was Ken's final diagnosis along with DLBD. I

know that Cocaine also stimulates the Dopamine centers and I would think that

continued use of that would be a potential cause of PD, but studies have not

born me out. Oh well.

Love, Barbara

[Guest guest]

The information about neuroleptic drug induced Parkinsonianism is not new.

Those drugs have been used for years for Schizophrenia which is the opposite

of Parkinson's since it seems to come from an excess of Dopamine. The

neuroleptic drugs mentioned were specifically designed to cut down on

Dopamine so the obvious result of too much of them was PD symptoms which

usually go away when the drugs are reduced or removed. When a patient with

Parkinson's gets too much Sinemet, the symptoms are often the same as those

of Schizophrenia, and can be sometimes counteracted with a small dose of a

neuroleptic. Also, animal models of Parkinson's are induced with drugs for

researchers to find drugs that will help PD. You may remember a number of

years ago when some people in San Francisco tried to make Heroin in the lab

and got something else that gave them all instant Parkinson's which did not

abate when the drug was withdrawn.

The talk about whether Alcoholism is a factor is interesting because I

have always wondered about it as Ken was a recovered alcoholic. However,

studies that have been done have shown a negative correlation between

Alcoholism and Parkinson's which was Ken's final diagnosis along with DLBD. I

know that Cocaine also stimulates the Dopamine centers and I would think that

continued use of that would be a potential cause of PD, but studies have not

born me out. Oh well.

Love, Barbara

[Guest guest]

That link was very interesting Deborah! I looked up neuroleptic and found

this information page on toxicity of

neuroleptic drugs.

http://www.emedicine.com/EMERG/topic338.htm

This is a small snippet from this page:

" Background: The term neuroleptic refers to the effects on cognition and

behavior of antipsychotic drugs that reduce confusion, delusions,

hallucinations, and psychomotor agitation in patients with psychoses. Also

known as major tranquilizers and antipsychotic drugs, neuroleptic agents

comprise a group of the following 7 classes of drugs:

Phenothiazines, further divided into the aliphatics, piperidines, and

piperazines

Thioxanthenes

Butyrophenones (eg, haloperidol)

Dibenzoxazepines (eg, loxapine)

Dihydroindolone (eg, molindone)

Diphenylbutylpiperidine (eg, pimozide)

Benzisoxazole (eg, risperidone) "

Regards,

Pam

Re: Cold hands and feet

Bill,

Thanks for you kind response. Believe it or not, I have never been tested

for circulation problems in any way, shape or form.

The MSA was drug-induced. Here is an article that I found on it while

doing my research. It helps to explain why all of the wonderful MDS's that

I saw were certain of their diagnosis.

http://www.cmdg.org/Movement_/drug/Acute_Parkinsons/acute_parkinsons.htm

[Guest guest]

That link was very interesting Deborah! I looked up neuroleptic and found

this information page on toxicity of

neuroleptic drugs.

http://www.emedicine.com/EMERG/topic338.htm

This is a small snippet from this page:

" Background: The term neuroleptic refers to the effects on cognition and

behavior of antipsychotic drugs that reduce confusion, delusions,

hallucinations, and psychomotor agitation in patients with psychoses. Also

known as major tranquilizers and antipsychotic drugs, neuroleptic agents

comprise a group of the following 7 classes of drugs:

Phenothiazines, further divided into the aliphatics, piperidines, and

piperazines

Thioxanthenes

Butyrophenones (eg, haloperidol)

Dibenzoxazepines (eg, loxapine)

Dihydroindolone (eg, molindone)

Diphenylbutylpiperidine (eg, pimozide)

Benzisoxazole (eg, risperidone) "

Regards,

Pam

Re: Cold hands and feet

Bill,

Thanks for you kind response. Believe it or not, I have never been tested

for circulation problems in any way, shape or form.

The MSA was drug-induced. Here is an article that I found on it while

doing my research. It helps to explain why all of the wonderful MDS's that

I saw were certain of their diagnosis.

http://www.cmdg.org/Movement_/drug/Acute_Parkinsons/acute_parkinsons.htm

[Guest guest]

Pam,

Yes, I found that article too but have never taken any of the medications

listed. Still doing research on Drug-Induced Parkinsonism.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

Reply-To: shydrager

To: <shydrager >

Subject: RE: Neuroleptic induced Parkinsonism - Deborah

Date: Wed, 6 Nov 2002 11:14:11 -0400

That link was very interesting Deborah! I looked up neuroleptic and found

this information page on toxicity of

neuroleptic drugs.

http://www.emedicine.com/EMERG/topic338.htm

This is a small snippet from this page:

" Background: The term neuroleptic refers to the effects on cognition and

behavior of antipsychotic drugs that reduce confusion, delusions,

hallucinations, and psychomotor agitation in patients with psychoses. Also

known as major tranquilizers and antipsychotic drugs, neuroleptic agents

comprise a group of the following 7 classes of drugs:

Phenothiazines, further divided into the aliphatics, piperidines, and

piperazines

Thioxanthenes

Butyrophenones (eg, haloperidol)

Dibenzoxazepines (eg, loxapine)

Dihydroindolone (eg, molindone)

Diphenylbutylpiperidine (eg, pimozide)

Benzisoxazole (eg, risperidone) "

Regards,

Pam

Re: Cold hands and feet

Bill,

Thanks for you kind response. Believe it or not, I have never been

tested

for circulation problems in any way, shape or form.

The MSA was drug-induced. Here is an article that I found on it while

doing my research. It helps to explain why all of the wonderful MDS's that

I saw were certain of their diagnosis.

http://www.cmdg.org/Movement_/drug/Acute_Parkinsons/acute_parkinsons.htm

If you do not wish to belong to shydrager, you may

unsubscribe by sending a blank email to

shydrager-unsubscribe

[Guest guest]

Pam,

Yes, I found that article too but have never taken any of the medications

listed. Still doing research on Drug-Induced Parkinsonism.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

Reply-To: shydrager

To: <shydrager >

Subject: RE: Neuroleptic induced Parkinsonism - Deborah

Date: Wed, 6 Nov 2002 11:14:11 -0400

That link was very interesting Deborah! I looked up neuroleptic and found

this information page on toxicity of

neuroleptic drugs.

http://www.emedicine.com/EMERG/topic338.htm

This is a small snippet from this page:

" Background: The term neuroleptic refers to the effects on cognition and

behavior of antipsychotic drugs that reduce confusion, delusions,

hallucinations, and psychomotor agitation in patients with psychoses. Also

known as major tranquilizers and antipsychotic drugs, neuroleptic agents

comprise a group of the following 7 classes of drugs:

Phenothiazines, further divided into the aliphatics, piperidines, and

piperazines

Thioxanthenes

Butyrophenones (eg, haloperidol)

Dibenzoxazepines (eg, loxapine)

Dihydroindolone (eg, molindone)

Diphenylbutylpiperidine (eg, pimozide)

Benzisoxazole (eg, risperidone) "

Regards,

Pam

Re: Cold hands and feet

Bill,

Thanks for you kind response. Believe it or not, I have never been

tested

for circulation problems in any way, shape or form.

The MSA was drug-induced. Here is an article that I found on it while

doing my research. It helps to explain why all of the wonderful MDS's that

I saw were certain of their diagnosis.

http://www.cmdg.org/Movement_/drug/Acute_Parkinsons/acute_parkinsons.htm

If you do not wish to belong to shydrager, you may

unsubscribe by sending a blank email to

shydrager-unsubscribe

[Guest guest]

Jean,

No problem. Glad both Pam's and my articles provided you with some

information. Needless to say, I have a vested interest into finding out the

origins of the physical problems that led to my mis-diagnosis of MSA. I

have not found many outside of the use of MPTP (Never did that one) and

drugs related to schizophrenia (Never took those either). Since I never took

meds to decrease dopamine, these studies do not apply to me. I was given

meds to increase dopamine production, not decrease it.

It has been well known, for quite some time, that schizophrenia is the

opposite of PD and many PD+ disorders. It is the result of too much

dopamine in the brain and thus medications are given to reduce dopamine in

these patients in an effort to control their psychosis. The result can be,

and is frequently documented by scientific studies, as a drug induced PD or

PD+ syndromes. Haldol was one of the worse meds in causing this to happen.

Workers in psychiatric institutions often referred to these patients as

having the " Haldol Shuffle " . Fortunately, for people currently suffering

with schizophrenia, there are less damaging drugs available today than there

were say, 10 years ago.

I am still searching for info on drug-induced Parkinsonian syndromes,

specifically ones caused by the PD meds that I was on, ones that increase

dopamine production. The article I posted is the only one that I have

found, so far, that is related directly to PD medications causing this to

happen.

When in NY in August, the tests that were run on me pointed most likely

to a drug-induced MSA caused by the medications to increase dopamine

production. Granted, there are more problems than that going on with me

that had to be taken into consideration, but the current treatment protocol

that I am on has me feeling better than I have in years. Most of my symptoms

have completely gone. I haven't fallen since August, I am walking without

again and not using any balancing assistance. Many, many more of the

symptoms that were totally debilitating me have vanished within a 2 month

period. The physical change in me is quite dramatic.

If anyone else finds something specific to drug-induced MSA, caused by

traditional PD and PD+ drug therapy, please send it on to me... offline will

be fine since it doesn't specifically relate to the majority of the people

on this list.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

_________________________________________________________________

MSN 8 with e-mail virus protection service: 2 months FREE*

http://join.msn.com/?page=features/virus

[Guest guest]

Jean,

No problem. Glad both Pam's and my articles provided you with some

information. Needless to say, I have a vested interest into finding out the

origins of the physical problems that led to my mis-diagnosis of MSA. I

have not found many outside of the use of MPTP (Never did that one) and

drugs related to schizophrenia (Never took those either). Since I never took

meds to decrease dopamine, these studies do not apply to me. I was given

meds to increase dopamine production, not decrease it.

It has been well known, for quite some time, that schizophrenia is the

opposite of PD and many PD+ disorders. It is the result of too much

dopamine in the brain and thus medications are given to reduce dopamine in

these patients in an effort to control their psychosis. The result can be,

and is frequently documented by scientific studies, as a drug induced PD or

PD+ syndromes. Haldol was one of the worse meds in causing this to happen.

Workers in psychiatric institutions often referred to these patients as

having the " Haldol Shuffle " . Fortunately, for people currently suffering

with schizophrenia, there are less damaging drugs available today than there

were say, 10 years ago.

I am still searching for info on drug-induced Parkinsonian syndromes,

specifically ones caused by the PD meds that I was on, ones that increase

dopamine production. The article I posted is the only one that I have

found, so far, that is related directly to PD medications causing this to

happen.

When in NY in August, the tests that were run on me pointed most likely

to a drug-induced MSA caused by the medications to increase dopamine

production. Granted, there are more problems than that going on with me

that had to be taken into consideration, but the current treatment protocol

that I am on has me feeling better than I have in years. Most of my symptoms

have completely gone. I haven't fallen since August, I am walking without

again and not using any balancing assistance. Many, many more of the

symptoms that were totally debilitating me have vanished within a 2 month

period. The physical change in me is quite dramatic.

If anyone else finds something specific to drug-induced MSA, caused by

traditional PD and PD+ drug therapy, please send it on to me... offline will

be fine since it doesn't specifically relate to the majority of the people

on this list.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

_________________________________________________________________

MSN 8 with e-mail virus protection service: 2 months FREE*

http://join.msn.com/?page=features/virus

[Guest guest]

Jean,

Of course I will. As stated in my previous post... I can find lots of

articles on drugs that reduce dopamine causing this to happen but am not

having much luck finding articles producing this when given meds to increase

dopamine.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

From: Suicoaz@...

Reply-To: shydrager

To: shydrager

Subject: Re: RE: Neuroleptic induced Parkinsonism - Deborah

Date: Wed, 6 Nov 2002 11:33:06 EST

Deborah,

If you find anything else on the Drug-induced Parkinsons will you share it

with us?

Jean

(Phoenix)

If you do not wish to belong to shydrager, you may

unsubscribe by sending a blank email to

shydrager-unsubscribe

[Guest guest]

Jean,

Of course I will. As stated in my previous post... I can find lots of

articles on drugs that reduce dopamine causing this to happen but am not

having much luck finding articles producing this when given meds to increase

dopamine.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

From: Suicoaz@...

Reply-To: shydrager

To: shydrager

Subject: Re: RE: Neuroleptic induced Parkinsonism - Deborah

Date: Wed, 6 Nov 2002 11:33:06 EST

Deborah,

If you find anything else on the Drug-induced Parkinsons will you share it

with us?

Jean

(Phoenix)

If you do not wish to belong to shydrager, you may

unsubscribe by sending a blank email to

shydrager-unsubscribe

[Guest guest]

Hi.

well. ... never smoked, drank, family didn't. In fact I have gone

through many h.h.aides because I will not tolerate smoking around me or

my home.

Sometimes things just happen.

Barb so good to see u posting.

nancy m.

kmcrae@... wrote:

>

> The information about neuroleptic drug induced Parkinsonianism is not new.

> Those drugs have been used for years for Schizophrenia which is the opposite

> of Parkinson's since it seems to come from an excess of Dopamine. The

> neuroleptic drugs mentioned were specifically designed to cut down on

> Dopamine so the obvious result of too much of them was PD symptoms which

> usually go away when the drugs are reduced or removed. When a patient with

> Parkinson's gets too much Sinemet, the symptoms are often the same as those

> of Schizophrenia, and can be sometimes counteracted with a small dose of a

> neuroleptic. Also, animal models of Parkinson's are induced with drugs for

> researchers to find drugs that will help PD. You may remember a number of

> years ago when some people in San Francisco tried to make Heroin in the lab

> and got something else that gave them all instant Parkinson's which did not

> abate when the drug was withdrawn.

> The talk about whether Alcoholism is a factor is interesting because I

> have always wondered about it as Ken was a recovered alcoholic. However,

> studies that have been done have shown a negative correlation between

> Alcoholism and Parkinson's which was Ken's final diagnosis along with DLBD. I

> know that Cocaine also stimulates the Dopamine centers and I would think that

> continued use of that would be a potential cause of PD, but studies have not

> born me out. Oh well.

> Love, Barbara

>

>

[Guest guest]

Hi.

well. ... never smoked, drank, family didn't. In fact I have gone

through many h.h.aides because I will not tolerate smoking around me or

my home.

Sometimes things just happen.

Barb so good to see u posting.

nancy m.

kmcrae@... wrote:

>

> The information about neuroleptic drug induced Parkinsonianism is not new.

> Those drugs have been used for years for Schizophrenia which is the opposite

> of Parkinson's since it seems to come from an excess of Dopamine. The

> neuroleptic drugs mentioned were specifically designed to cut down on

> Dopamine so the obvious result of too much of them was PD symptoms which

> usually go away when the drugs are reduced or removed. When a patient with

> Parkinson's gets too much Sinemet, the symptoms are often the same as those

> of Schizophrenia, and can be sometimes counteracted with a small dose of a

> neuroleptic. Also, animal models of Parkinson's are induced with drugs for

> researchers to find drugs that will help PD. You may remember a number of

> years ago when some people in San Francisco tried to make Heroin in the lab

> and got something else that gave them all instant Parkinson's which did not

> abate when the drug was withdrawn.

> The talk about whether Alcoholism is a factor is interesting because I

> have always wondered about it as Ken was a recovered alcoholic. However,

> studies that have been done have shown a negative correlation between

> Alcoholism and Parkinson's which was Ken's final diagnosis along with DLBD. I

> know that Cocaine also stimulates the Dopamine centers and I would think that

> continued use of that would be a potential cause of PD, but studies have not

> born me out. Oh well.

> Love, Barbara

>

>

[Guest guest]

There you are, . You never smoked you say, and they are testing to see

if nicotine patches will help PD patients since smokers seem to get PD less

often than others. So, since Ken both drank and smoked as a young man, how

could he end up with PD?

Thanks for welcoming me back. I was in France for a few weeks and had

a wonderful trip of a lifetime. It is good to be home, however.

love, Barbara

[Guest guest]

There you are, . You never smoked you say, and they are testing to see

if nicotine patches will help PD patients since smokers seem to get PD less

often than others. So, since Ken both drank and smoked as a young man, how

could he end up with PD?

Thanks for welcoming me back. I was in France for a few weeks and had

a wonderful trip of a lifetime. It is good to be home, however.

love, Barbara