Re: Celeste took a dramatic change down...seems odd

[Guest guest]

Hi Dawn,

I am so sorry to hear of Celeste's latest bout. Is the pain localized or all

over?

Please know that we are thinking of you and Celeste and hope you get some

answers soon.

Love,

Jean & Chrissie

[Guest guest]

Hi Dawn,

I am so sorry to hear of Celeste's latest bout. Is the pain localized or all

over?

Please know that we are thinking of you and Celeste and hope you get some

answers soon.

Love,

Jean & Chrissie

[Guest guest]

Dawn,

Oh, poor Celeste! Where is the pain? I suppose it could be neuropathic

pain. Has she had an MRI to rule out a brain tumor or spinal problem? I'm

afraid I'm not much help, but do tell her we're thinking about her.

Carol & Rob

Lexington, MA

Celeste took a dramatic change down...seems odd

> Celeste has taken such a dramatic change for the worst in the last

> couple of weeks. She has been in the hospital since Saturday with

> reduced mobility and pain which is so excruciating she just whales in

> pain and the moraphine barely touches it. She likens the pain to

> being electrocuded (sp?). The change was dramatic enought that we

> were convinced so had a UTI but she does not. What else besides

> infection can cause such a negative change so fast? She started a

> new drug 2 - 3 weeks ago and I am wondering whether it could be the

> culprit...Lexapro, I think is the name. I can't help but think

> something besides the illness is biting her....some drug she has

> become sensitive to or some drug interaction. Any ideas my friends?

> Best Regards,

> Dawn Morley

>

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

>

[Guest guest]

Dawn,

Oh, poor Celeste! Where is the pain? I suppose it could be neuropathic

pain. Has she had an MRI to rule out a brain tumor or spinal problem? I'm

afraid I'm not much help, but do tell her we're thinking about her.

Carol & Rob

Lexington, MA

Celeste took a dramatic change down...seems odd

> Celeste has taken such a dramatic change for the worst in the last

> couple of weeks. She has been in the hospital since Saturday with

> reduced mobility and pain which is so excruciating she just whales in

> pain and the moraphine barely touches it. She likens the pain to

> being electrocuded (sp?). The change was dramatic enought that we

> were convinced so had a UTI but she does not. What else besides

> infection can cause such a negative change so fast? She started a

> new drug 2 - 3 weeks ago and I am wondering whether it could be the

> culprit...Lexapro, I think is the name. I can't help but think

> something besides the illness is biting her....some drug she has

> become sensitive to or some drug interaction. Any ideas my friends?

> Best Regards,

> Dawn Morley

>

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

>

[Guest guest]

Dear Dawn,

How hard this must be for Celeste. In this case, I would also suspect the

Lexapro. You might want to ask if they can try removing it to see if it

helps. It might not, but as you noted, it's the only thing that changed

recently. It normally takes two to three weeks for some of these drugs to

reach full level in the body. I did check Lexapro for adverse reactions,

and that type of pain was not mentioned. But then it is unlikely anyone

with MSA or her current set of medications would be in their study group.

Keep us updated. Both of you will be in our prayers.

Regards,

=jbf=

B. Fisher

[Guest guest]

Dear Dawn,

How hard this must be for Celeste. In this case, I would also suspect the

Lexapro. You might want to ask if they can try removing it to see if it

helps. It might not, but as you noted, it's the only thing that changed

recently. It normally takes two to three weeks for some of these drugs to

reach full level in the body. I did check Lexapro for adverse reactions,

and that type of pain was not mentioned. But then it is unlikely anyone

with MSA or her current set of medications would be in their study group.

Keep us updated. Both of you will be in our prayers.

Regards,

=jbf=

B. Fisher

[Guest guest]

Hi. Sorry about Celeste!

What is Lexapro?? The hospital should be able to adjust the med, so that

they can tell if it is the drug as long as she is in the hospital.

dawnmorleyus wrote:

>

> Celeste has taken such a dramatic change for the worst in the last

> couple of weeks. She has been in the hospital since Saturday with

> reduced mobility and pain which is so excruciating she just whales in

> pain and the moraphine barely touches it. She likens the pain to

> being electrocuded (sp?).

Is the pain in her legs and abdomon???

I was on hydromorhone for the pain and it helped alittle at first and

the nothing. They did a urine culture in addition to the regular urine

sample.

Please keeps us informed.

nancy m.

The change was dramatic enough that we

> were convinced so had a UTI but she does not. What else besides

> infection can cause such a negative change so fast? She started a

> new drug 2 - 3 weeks ago and I am wondering whether it could be the

> culprit...Lexapro, I think is the name. I can't help but think

> something besides the illness is biting her....some drug she has

> become sensitive to or some drug interaction. Any ideas my friends?

> Best Regards,

> Dawn Morley

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

[Guest guest]

Hi. Sorry about Celeste!

What is Lexapro?? The hospital should be able to adjust the med, so that

they can tell if it is the drug as long as she is in the hospital.

dawnmorleyus wrote:

>

> Celeste has taken such a dramatic change for the worst in the last

> couple of weeks. She has been in the hospital since Saturday with

> reduced mobility and pain which is so excruciating she just whales in

> pain and the moraphine barely touches it. She likens the pain to

> being electrocuded (sp?).

Is the pain in her legs and abdomon???

I was on hydromorhone for the pain and it helped alittle at first and

the nothing. They did a urine culture in addition to the regular urine

sample.

Please keeps us informed.

nancy m.

The change was dramatic enough that we

> were convinced so had a UTI but she does not. What else besides

> infection can cause such a negative change so fast? She started a

> new drug 2 - 3 weeks ago and I am wondering whether it could be the

> culprit...Lexapro, I think is the name. I can't help but think

> something besides the illness is biting her....some drug she has

> become sensitive to or some drug interaction. Any ideas my friends?

> Best Regards,

> Dawn Morley

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

[Guest guest]

Dawn,

Here are some links on Lexapro

http://www.rxlist.com

The next one is the link to the drug interactions that I post below it.

http://www.pharmacist.com/monographs/lexapro.cfm

Drug Interactions:

Escitalopram: Substrate of CYP2C19, 3A4; Inhibits CYP2D6

Buspirone: Concurrent use of citalopram with buspirone may cause serotonin

syndrome; avoid concurrent use.

Cimetidine: May inhibit the metabolism of citalopram. CYP2D6 substrates

(tricyclic antidepressants): Use with caution; escitalopram increases the

Cmax of desipramine by 40% and increases the AUC by 100%.

Linezolid: Hyperpyrexia, hypertension, tachycardia, confusion, seizures, and

deaths have been reported with agents which inhibit MAO (serotonin

syndrome); this combination should be avoided.

MAO inhibitors: Hyperpyrexia, hypertension, tachycardia, confusion,

seizures, and deaths have been reported with MAO inhibitors (serotonin

syndrome); this combination should be avoided.

Meperidine: Combined use theoretically may increase the risk of serotonin

syndrome.

Metoprolol: Escitalopram may increase plasma levels of metoprolol; monitor

for increased effect.

Moclobemide: Concurrent use of citalopram with moclobemide may cause

serotonin syndrome; avoid concurrent use.

Nefazodone: Concurrent use of citalopram with nefazodone may cause serotonin

syndrome.

Selegiline: Concurrent use with citalopram has been reported to cause

serotonin syndrome; as an MAO type B inhibitor, the risk of serotonin

syndrome may be less than with nonselective MAO inhibitors, and reports

indicate that this combination has been well tolerated in Parkinson's

patients.

SSRIs: Concurrent use with other reuptake inhibitors may increase the risk

of serotonin syndrome.

Sibutramine: May increase the risk of serotonin syndrome with SSRIs.

Sumatriptan (and other serotonin agonists): Concurrent use may result in

toxicity; weakness, hyper-reflexia, and incoordination have been observed

with sumatriptan and SSRIs. In addition, concurrent use may theoretically

increase the risk of serotonin syndrome; includes sumatriptan, naratriptan,

rizatriptan, and zolmitriptan.

Tramadol: Concurrent use of citalopram with tramadol may cause serotonin

syndrome; avoid concurrent use.

Trazodone: Concurrent use of citalopram with trazodone may cause serotonin

syndrome.

Venlafaxine: Combined use with citalopram may increase the risk of serotonin

syndrome.

Dawn,

Sorry to post it all right here instead of just the link but I thought

that this would be easier for you. I would think that the Lexapro is having

an interaction with the other medications. Since I do not know what Celeste

is on, I could not research that for you. You might want to try

http://www.drugs.com/xq/cfm/pageID_1150/int_0/qx/index.htm

which is a drug-interaction database.

Give Celeste & my love and tell her we hope she gets to feeling

better soon... a hospital is no place to be when you feel so bad.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

_________________________________________________________________

Tired of spam? Get advanced junk mail protection with MSN 8.

http://join.msn.com/?page=features/junkmail

[Guest guest]

Dawn,

Here are some links on Lexapro

http://www.rxlist.com

The next one is the link to the drug interactions that I post below it.

http://www.pharmacist.com/monographs/lexapro.cfm

Drug Interactions:

Escitalopram: Substrate of CYP2C19, 3A4; Inhibits CYP2D6

Buspirone: Concurrent use of citalopram with buspirone may cause serotonin

syndrome; avoid concurrent use.

Cimetidine: May inhibit the metabolism of citalopram. CYP2D6 substrates

(tricyclic antidepressants): Use with caution; escitalopram increases the

Cmax of desipramine by 40% and increases the AUC by 100%.

Linezolid: Hyperpyrexia, hypertension, tachycardia, confusion, seizures, and

deaths have been reported with agents which inhibit MAO (serotonin

syndrome); this combination should be avoided.

MAO inhibitors: Hyperpyrexia, hypertension, tachycardia, confusion,

seizures, and deaths have been reported with MAO inhibitors (serotonin

syndrome); this combination should be avoided.

Meperidine: Combined use theoretically may increase the risk of serotonin

syndrome.

Metoprolol: Escitalopram may increase plasma levels of metoprolol; monitor

for increased effect.

Moclobemide: Concurrent use of citalopram with moclobemide may cause

serotonin syndrome; avoid concurrent use.

Nefazodone: Concurrent use of citalopram with nefazodone may cause serotonin

syndrome.

Selegiline: Concurrent use with citalopram has been reported to cause

serotonin syndrome; as an MAO type B inhibitor, the risk of serotonin

syndrome may be less than with nonselective MAO inhibitors, and reports

indicate that this combination has been well tolerated in Parkinson's

patients.

SSRIs: Concurrent use with other reuptake inhibitors may increase the risk

of serotonin syndrome.

Sibutramine: May increase the risk of serotonin syndrome with SSRIs.

Sumatriptan (and other serotonin agonists): Concurrent use may result in

toxicity; weakness, hyper-reflexia, and incoordination have been observed

with sumatriptan and SSRIs. In addition, concurrent use may theoretically

increase the risk of serotonin syndrome; includes sumatriptan, naratriptan,

rizatriptan, and zolmitriptan.

Tramadol: Concurrent use of citalopram with tramadol may cause serotonin

syndrome; avoid concurrent use.

Trazodone: Concurrent use of citalopram with trazodone may cause serotonin

syndrome.

Venlafaxine: Combined use with citalopram may increase the risk of serotonin

syndrome.

Dawn,

Sorry to post it all right here instead of just the link but I thought

that this would be easier for you. I would think that the Lexapro is having

an interaction with the other medications. Since I do not know what Celeste

is on, I could not research that for you. You might want to try

http://www.drugs.com/xq/cfm/pageID_1150/int_0/qx/index.htm

which is a drug-interaction database.

Give Celeste & my love and tell her we hope she gets to feeling

better soon... a hospital is no place to be when you feel so bad.

Hugs and Warm Fuzzies,

Deborah aka Tenacity

Personal website & photo's

http://www.pdhangout.com

http://community.webshots.com/user/tenacitywins

_________________________________________________________________

Tired of spam? Get advanced junk mail protection with MSN 8.

http://join.msn.com/?page=features/junkmail

[Guest guest]

Deborah & Dawn,

I think you hit the nail on the head. I looked at the interactions and I

suspect the Lexapro is interacting with one of the Parkinson's meds or

another antidepressant.

Dawn, you should also know that in general (and this is not true for

everyone) MSA patients do NOT tolerate SSRI-type antidepressants well. From

personal experience, Rob has had TERRIBLE sleep problems every time he has

been given an SSRI.

I hope this gets resolved soon and that Celeste gets some relief.

Carol & Rob

Lexington, MA

Re: Celeste took a dramatic change down...seems odd

> Dawn,

>

> Here are some links on Lexapro

>

> http://www.rxlist.com

>

> The next one is the link to the drug interactions that I post below it.

> http://www.pharmacist.com/monographs/lexapro.cfm

>

> Drug Interactions:

>

> Escitalopram: Substrate of CYP2C19, 3A4; Inhibits CYP2D6

>

> Buspirone: Concurrent use of citalopram with buspirone may cause serotonin

> syndrome; avoid concurrent use.

>

> Cimetidine: May inhibit the metabolism of citalopram. CYP2D6 substrates

> (tricyclic antidepressants): Use with caution; escitalopram increases the

> Cmax of desipramine by 40% and increases the AUC by 100%.

>

> Linezolid: Hyperpyrexia, hypertension, tachycardia, confusion, seizures,

and

> deaths have been reported with agents which inhibit MAO (serotonin

> syndrome); this combination should be avoided.

>

> MAO inhibitors: Hyperpyrexia, hypertension, tachycardia, confusion,

> seizures, and deaths have been reported with MAO inhibitors (serotonin

> syndrome); this combination should be avoided.

>

> Meperidine: Combined use theoretically may increase the risk of serotonin

> syndrome.

>

> Metoprolol: Escitalopram may increase plasma levels of metoprolol; monitor

> for increased effect.

>

> Moclobemide: Concurrent use of citalopram with moclobemide may cause

> serotonin syndrome; avoid concurrent use.

>

> Nefazodone: Concurrent use of citalopram with nefazodone may cause

serotonin

> syndrome.

>

> Selegiline: Concurrent use with citalopram has been reported to cause

> serotonin syndrome; as an MAO type B inhibitor, the risk of serotonin

> syndrome may be less than with nonselective MAO inhibitors, and reports

> indicate that this combination has been well tolerated in Parkinson's

> patients.

>

> SSRIs: Concurrent use with other reuptake inhibitors may increase the risk

> of serotonin syndrome.

>

> Sibutramine: May increase the risk of serotonin syndrome with SSRIs.

>

> Sumatriptan (and other serotonin agonists): Concurrent use may result in

> toxicity; weakness, hyper-reflexia, and incoordination have been observed

> with sumatriptan and SSRIs. In addition, concurrent use may theoretically

> increase the risk of serotonin syndrome; includes sumatriptan,

naratriptan,

> rizatriptan, and zolmitriptan.

>

> Tramadol: Concurrent use of citalopram with tramadol may cause serotonin

> syndrome; avoid concurrent use.

>

> Trazodone: Concurrent use of citalopram with trazodone may cause serotonin

> syndrome.

>

> Venlafaxine: Combined use with citalopram may increase the risk of

serotonin

> syndrome.

>

> Dawn,

>

> Sorry to post it all right here instead of just the link but I thought

> that this would be easier for you. I would think that the Lexapro is

having

> an interaction with the other medications. Since I do not know what

Celeste

> is on, I could not research that for you. You might want to try

>

> http://www.drugs.com/xq/cfm/pageID_1150/int_0/qx/index.htm

>

> which is a drug-interaction database.

>

> Give Celeste & my love and tell her we hope she gets to feeling

> better soon... a hospital is no place to be when you feel so bad.

>

> Hugs and Warm Fuzzies,

> Deborah aka Tenacity

>

> Personal website & photo's

> http://www.pdhangout.com

> http://community.webshots.com/user/tenacitywins

>

>

>

> _________________________________________________________________

> Tired of spam? Get advanced junk mail protection with MSN 8.

> http://join.msn.com/?page=features/junkmail

>

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

>

[Guest guest]

Deborah & Dawn,

I think you hit the nail on the head. I looked at the interactions and I

suspect the Lexapro is interacting with one of the Parkinson's meds or

another antidepressant.

Dawn, you should also know that in general (and this is not true for

everyone) MSA patients do NOT tolerate SSRI-type antidepressants well. From

personal experience, Rob has had TERRIBLE sleep problems every time he has

been given an SSRI.

I hope this gets resolved soon and that Celeste gets some relief.

Carol & Rob

Lexington, MA

Re: Celeste took a dramatic change down...seems odd

> Dawn,

>

> Here are some links on Lexapro

>

> http://www.rxlist.com

>

> The next one is the link to the drug interactions that I post below it.

> http://www.pharmacist.com/monographs/lexapro.cfm

>

> Drug Interactions:

>

> Escitalopram: Substrate of CYP2C19, 3A4; Inhibits CYP2D6

>

> Buspirone: Concurrent use of citalopram with buspirone may cause serotonin

> syndrome; avoid concurrent use.

>

> Cimetidine: May inhibit the metabolism of citalopram. CYP2D6 substrates

> (tricyclic antidepressants): Use with caution; escitalopram increases the

> Cmax of desipramine by 40% and increases the AUC by 100%.

>

> Linezolid: Hyperpyrexia, hypertension, tachycardia, confusion, seizures,

and

> deaths have been reported with agents which inhibit MAO (serotonin

> syndrome); this combination should be avoided.

>

> MAO inhibitors: Hyperpyrexia, hypertension, tachycardia, confusion,

> seizures, and deaths have been reported with MAO inhibitors (serotonin

> syndrome); this combination should be avoided.

>

> Meperidine: Combined use theoretically may increase the risk of serotonin

> syndrome.

>

> Metoprolol: Escitalopram may increase plasma levels of metoprolol; monitor

> for increased effect.

>

> Moclobemide: Concurrent use of citalopram with moclobemide may cause

> serotonin syndrome; avoid concurrent use.

>

> Nefazodone: Concurrent use of citalopram with nefazodone may cause

serotonin

> syndrome.

>

> Selegiline: Concurrent use with citalopram has been reported to cause

> serotonin syndrome; as an MAO type B inhibitor, the risk of serotonin

> syndrome may be less than with nonselective MAO inhibitors, and reports

> indicate that this combination has been well tolerated in Parkinson's

> patients.

>

> SSRIs: Concurrent use with other reuptake inhibitors may increase the risk

> of serotonin syndrome.

>

> Sibutramine: May increase the risk of serotonin syndrome with SSRIs.

>

> Sumatriptan (and other serotonin agonists): Concurrent use may result in

> toxicity; weakness, hyper-reflexia, and incoordination have been observed

> with sumatriptan and SSRIs. In addition, concurrent use may theoretically

> increase the risk of serotonin syndrome; includes sumatriptan,

naratriptan,

> rizatriptan, and zolmitriptan.

>

> Tramadol: Concurrent use of citalopram with tramadol may cause serotonin

> syndrome; avoid concurrent use.

>

> Trazodone: Concurrent use of citalopram with trazodone may cause serotonin

> syndrome.

>

> Venlafaxine: Combined use with citalopram may increase the risk of

serotonin

> syndrome.

>

> Dawn,

>

> Sorry to post it all right here instead of just the link but I thought

> that this would be easier for you. I would think that the Lexapro is

having

> an interaction with the other medications. Since I do not know what

Celeste

> is on, I could not research that for you. You might want to try

>

> http://www.drugs.com/xq/cfm/pageID_1150/int_0/qx/index.htm

>

> which is a drug-interaction database.

>

> Give Celeste & my love and tell her we hope she gets to feeling

> better soon... a hospital is no place to be when you feel so bad.

>

> Hugs and Warm Fuzzies,

> Deborah aka Tenacity

>

> Personal website & photo's

> http://www.pdhangout.com

> http://community.webshots.com/user/tenacitywins

>

>

>

> _________________________________________________________________

> Tired of spam? Get advanced junk mail protection with MSN 8.

> http://join.msn.com/?page=features/junkmail

>

>

> If you do not wish to belong to shydrager, you may

> unsubscribe by sending a blank email to

>

> shydrager-unsubscribe

>

>

>

>

>