Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 Has anyone discussed with the Mito docs using Creatine Monhydrate in the cocktails? Department of Neurology, McMaster University Medical Center, Hamilton, Ontario, Canada. Fatigue in patients with mitochondrial cytopathies is associated with decreased basal and postactivity muscle phosphocreatine (PCr). Creatine monohydrate supplementation has been shown to increase muscle PCr and high-intensity power output in healthy subjects. We studied the effects of creatine monohydrate administration (5 g PO b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial cytopathy patients using a randomized, crossover design. Measurements included: activities of daily living (visual analog scale); ischemic isometric handgrip strength (1 min); basal and postischemic exercise lactate; evoked and voluntary contraction strength of the dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 min); and aerobic cycle ergometry with pre- and post-lactate measurements. Creatine treatment resulted in significantly (P < 0.05) increased handgrip strength, NIDFT, and postexercise lactate, with no changes in the other measured variables. We concluded that creatine monohydrate increased the strength of high-intensity anaerobic and aerobic type activities in patients with mitochondrial cytopathies but had no apparent effects upon lower intensity aerobic activities. Publication Types: Clinical Trial Randomized Controlled Trial PMID: 9390662 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 Has anyone discussed with the Mito docs using Creatine Monhydrate in the cocktails? Department of Neurology, McMaster University Medical Center, Hamilton, Ontario, Canada. Fatigue in patients with mitochondrial cytopathies is associated with decreased basal and postactivity muscle phosphocreatine (PCr). Creatine monohydrate supplementation has been shown to increase muscle PCr and high-intensity power output in healthy subjects. We studied the effects of creatine monohydrate administration (5 g PO b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial cytopathy patients using a randomized, crossover design. Measurements included: activities of daily living (visual analog scale); ischemic isometric handgrip strength (1 min); basal and postischemic exercise lactate; evoked and voluntary contraction strength of the dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 min); and aerobic cycle ergometry with pre- and post-lactate measurements. Creatine treatment resulted in significantly (P < 0.05) increased handgrip strength, NIDFT, and postexercise lactate, with no changes in the other measured variables. We concluded that creatine monohydrate increased the strength of high-intensity anaerobic and aerobic type activities in patients with mitochondrial cytopathies but had no apparent effects upon lower intensity aerobic activities. Publication Types: Clinical Trial Randomized Controlled Trial PMID: 9390662 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 and Lindsey have been on creatine monohydrate since November. I think it has helped give them more energy and stamina. They currently take 1g t.i.d. Kim - Mom to and Lindsey (3) Partial Complex I Creatine Monohydrate > > > Has anyone discussed with the Mito docs using Creatine Monhydrate in > the cocktails? > > > Department of Neurology, McMaster University Medical Center, > Hamilton, Ontario, Canada. > > Fatigue in patients with mitochondrial cytopathies is associated with > decreased basal and postactivity muscle phosphocreatine (PCr). > Creatine monohydrate supplementation has been shown to increase > muscle PCr and high-intensity power output in healthy subjects. We > studied the effects of creatine monohydrate administration (5 g PO > b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial > cytopathy patients using a randomized, crossover design. Measurements > included: activities of daily living (visual analog scale); ischemic > isometric handgrip strength (1 min); basal and postischemic exercise > lactate; evoked and voluntary contraction strength of the > dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 > min); and aerobic cycle ergometry with pre- and post-lactate > measurements. Creatine treatment resulted in significantly (P < 0.05) > increased handgrip strength, NIDFT, and postexercise lactate, with no > changes in the other measured variables. We concluded that creatine > monohydrate increased the strength of high-intensity anaerobic and > aerobic type activities in patients with mitochondrial cytopathies > but had no apparent effects upon lower intensity aerobic activities. > > Publication Types: > Clinical Trial > Randomized Controlled Trial > > PMID: 9390662 [PubMed - indexed for MEDLINE] > > > > > > > Please contact mito-owner with any problems or questions. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 and Lindsey have been on creatine monohydrate since November. I think it has helped give them more energy and stamina. They currently take 1g t.i.d. Kim - Mom to and Lindsey (3) Partial Complex I Creatine Monohydrate > > > Has anyone discussed with the Mito docs using Creatine Monhydrate in > the cocktails? > > > Department of Neurology, McMaster University Medical Center, > Hamilton, Ontario, Canada. > > Fatigue in patients with mitochondrial cytopathies is associated with > decreased basal and postactivity muscle phosphocreatine (PCr). > Creatine monohydrate supplementation has been shown to increase > muscle PCr and high-intensity power output in healthy subjects. We > studied the effects of creatine monohydrate administration (5 g PO > b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial > cytopathy patients using a randomized, crossover design. Measurements > included: activities of daily living (visual analog scale); ischemic > isometric handgrip strength (1 min); basal and postischemic exercise > lactate; evoked and voluntary contraction strength of the > dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 > min); and aerobic cycle ergometry with pre- and post-lactate > measurements. Creatine treatment resulted in significantly (P < 0.05) > increased handgrip strength, NIDFT, and postexercise lactate, with no > changes in the other measured variables. We concluded that creatine > monohydrate increased the strength of high-intensity anaerobic and > aerobic type activities in patients with mitochondrial cytopathies > but had no apparent effects upon lower intensity aerobic activities. > > Publication Types: > Clinical Trial > Randomized Controlled Trial > > PMID: 9390662 [PubMed - indexed for MEDLINE] > > > > > > > Please contact mito-owner with any problems or questions. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 My kids take creatine- but only before and after sports. Cindy-GA Creatine Monohydrate>>> Has anyone discussed with the Mito docs using Creatine Monhydrate in> the cocktails?>>> Department of Neurology, McMaster University Medical Center,> Hamilton, Ontario, Canada.>> Fatigue in patients with mitochondrial cytopathies is associated with> decreased basal and postactivity muscle phosphocreatine (PCr).> Creatine monohydrate supplementation has been shown to increase> muscle PCr and high-intensity power output in healthy subjects. We> studied the effects of creatine monohydrate administration (5 g PO> b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial> cytopathy patients using a randomized, crossover design. Measurements> included: activities of daily living (visual analog scale); ischemic> isometric handgrip strength (1 min); basal and postischemic exercise> lactate; evoked and voluntary contraction strength of the> dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2> min); and aerobic cycle ergometry with pre- and post-lactate> measurements. Creatine treatment resulted in significantly (P < 0.05)> increased handgrip strength, NIDFT, and postexercise lactate, with no> changes in the other measured variables. We concluded that creatine> monohydrate increased the strength of high-intensity anaerobic and> aerobic type activities in patients with mitochondrial cytopathies> but had no apparent effects upon lower intensity aerobic activities.>> Publication Types:> Clinical Trial> Randomized Controlled Trial>> PMID: 9390662 [PubMed - indexed for MEDLINE]>>>>>>> Please contact mito-owner with any problems or questions.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2005 Report Share Posted February 9, 2005 My kids take creatine- but only before and after sports. Cindy-GA Creatine Monohydrate>>> Has anyone discussed with the Mito docs using Creatine Monhydrate in> the cocktails?>>> Department of Neurology, McMaster University Medical Center,> Hamilton, Ontario, Canada.>> Fatigue in patients with mitochondrial cytopathies is associated with> decreased basal and postactivity muscle phosphocreatine (PCr).> Creatine monohydrate supplementation has been shown to increase> muscle PCr and high-intensity power output in healthy subjects. We> studied the effects of creatine monohydrate administration (5 g PO> b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial> cytopathy patients using a randomized, crossover design. Measurements> included: activities of daily living (visual analog scale); ischemic> isometric handgrip strength (1 min); basal and postischemic exercise> lactate; evoked and voluntary contraction strength of the> dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2> min); and aerobic cycle ergometry with pre- and post-lactate> measurements. Creatine treatment resulted in significantly (P < 0.05)> increased handgrip strength, NIDFT, and postexercise lactate, with no> changes in the other measured variables. We concluded that creatine> monohydrate increased the strength of high-intensity anaerobic and> aerobic type activities in patients with mitochondrial cytopathies> but had no apparent effects upon lower intensity aerobic activities.>> Publication Types:> Clinical Trial> Randomized Controlled Trial>> PMID: 9390662 [PubMed - indexed for MEDLINE]>>>>>>> Please contact mito-owner with any problems or questions.> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 I asked Dr Cohen about this and he told me he only uses Creatine for certain situations and patients. He does not recommend it as part of the " regular cocktail " for his patients. I imagine your Mito Doc or PCP might be able to tell you if it is appropriate for you. My older son who is far less affected has taken it in the past when he gets very sick and his muscles cramp up and he is unable to walk. Drew has more muscle issues than his younger brother who suffers with more Encephalopy of the brain. Hope this helps. > > Has anyone discussed with the Mito docs using Creatine Monhydrate in > the cocktails? > > > Department of Neurology, McMaster University Medical Center, > Hamilton, Ontario, Canada. > > Fatigue in patients with mitochondrial cytopathies is associated with > decreased basal and postactivity muscle phosphocreatine (PCr). > Creatine monohydrate supplementation has been shown to increase > muscle PCr and high-intensity power output in healthy subjects. We > studied the effects of creatine monohydrate administration (5 g PO > b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial > cytopathy patients using a randomized, crossover design. Measurements > included: activities of daily living (visual analog scale); ischemic > isometric handgrip strength (1 min); basal and postischemic exercise > lactate; evoked and voluntary contraction strength of the > dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 > min); and aerobic cycle ergometry with pre- and post-lactate > measurements. Creatine treatment resulted in significantly (P < 0.05) > increased handgrip strength, NIDFT, and postexercise lactate, with no > changes in the other measured variables. We concluded that creatine > monohydrate increased the strength of high-intensity anaerobic and > aerobic type activities in patients with mitochondrial cytopathies > but had no apparent effects upon lower intensity aerobic activities. > > Publication Types: > Clinical Trial > Randomized Controlled Trial > > PMID: 9390662 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 11, 2005 Report Share Posted February 11, 2005 I asked Dr Cohen about this and he told me he only uses Creatine for certain situations and patients. He does not recommend it as part of the " regular cocktail " for his patients. I imagine your Mito Doc or PCP might be able to tell you if it is appropriate for you. My older son who is far less affected has taken it in the past when he gets very sick and his muscles cramp up and he is unable to walk. Drew has more muscle issues than his younger brother who suffers with more Encephalopy of the brain. Hope this helps. > > Has anyone discussed with the Mito docs using Creatine Monhydrate in > the cocktails? > > > Department of Neurology, McMaster University Medical Center, > Hamilton, Ontario, Canada. > > Fatigue in patients with mitochondrial cytopathies is associated with > decreased basal and postactivity muscle phosphocreatine (PCr). > Creatine monohydrate supplementation has been shown to increase > muscle PCr and high-intensity power output in healthy subjects. We > studied the effects of creatine monohydrate administration (5 g PO > b.i.d. x 14 days --> 2 g PO b.i.d. x 7 days) in 7 mitochondrial > cytopathy patients using a randomized, crossover design. Measurements > included: activities of daily living (visual analog scale); ischemic > isometric handgrip strength (1 min); basal and postischemic exercise > lactate; evoked and voluntary contraction strength of the > dorsiflexors; nonischemic, isometric, dorsiflexion torque (NIDFT, 2 > min); and aerobic cycle ergometry with pre- and post-lactate > measurements. Creatine treatment resulted in significantly (P < 0.05) > increased handgrip strength, NIDFT, and postexercise lactate, with no > changes in the other measured variables. We concluded that creatine > monohydrate increased the strength of high-intensity anaerobic and > aerobic type activities in patients with mitochondrial cytopathies > but had no apparent effects upon lower intensity aerobic activities. > > Publication Types: > Clinical Trial > Randomized Controlled Trial > > PMID: 9390662 [PubMed - indexed for MEDLINE] Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.