IgG3 low- what does it mean?

[Guest guest]

I received a phone call yeaterday from our daughter's GI saying most of

the subclass testing was normal but the IgG3 level was low. I was wondering

if anyone could help me understand if this is an important finding or if it

doesn't mean much.

See www.caringbridge.org/ia/mitomomof9 and www.heartbeatsformito.org to see

a photo look into what Mito looks like

Darla: mommy to

Asenath (4) Mito, CNS Vasculitis, strokes, migraines, seizures, G-tube,

hypotonicity, disautonomy, SID, global delays, asthma, cyclic vomiting,

bladder issues, wheelchair for distances, eye issues, autistic behaviors,

gastric emptying issues...

Zipporrah (14 months) Mito, strokes, neuro-motor planning dys., SID, GERD,

dysphasia, 100% G-tube fed, speech delays, extreme fatigue, excessive

phlegm, asthma, trach issues, aberrant subclavian artery, disautonomy,

hypertonicity, migraines, possible seizures, dumping syndrome, iron

deficiency, ...

Luke (16), Leah (14), Rachael (13), Isaac (10), Tirzah (8), Kezia (4), &

Marquis (3), Joey & (12 months) (some with Mito symptoms)

[Guest guest]

Darla,

I have the handbook of immunedeficiencies form the immune deficiency

foundatiion.

A low Ig3 is considered a IgG subclass deficiency.

IgG3 subclass is rich in antibodies against proteins such as toxins

produced by diptheria and tetnus bacteria, as well as antibodies

against viral proteins.IgG3 makes up 5-8% of the IgG circulating in

the blood stream. IgG3 doesnt reach normal levels until 5-7 years of

age. Mnay children outgrow subclass deficiencies.

patients with subclass deficiencies have frequent infections of ears,

sinuses and lungs. some have wheezing and reactive airway disease.

treatment consists of antibiotics and bronchodliaters. Since most

kids outgrow the deficiency it is recommended that they be retested

as they get older. ..

If the antibiotics dont work and the child doesnt outgrow the

deficiency then IVIG may be considered.

thats it in a nut shell...the article was a little longer but that is

the highlights..

hope it helps a bit

Oh and also I ran across a article the other day that sited steroids

used to prevent further SLE episodes..it was just one line in a

article about the kidneys and mito but it was there..